Import models

Import models from files

The function ~cameo.io.load_model accepts a number of different file formats like SBML (Systems Biology Markup Language) for example.

less data/e_coli_core.xml

from cameo import load_model
model = load_model('data/e_coli_core.xml')

model

Name	e_coli_core
Number of metabolites	72
Number of reactions	95
Reactions	coa_c + acald_c + nad_c <=> nadh_c + accoa_c + h_c acald_e <=> acald_c atp_c + ac_c <=> adp_c + actp_c cit_c <=> h2o_c + acon_C_c h2o_c + acon_C_c <=> icit_c h_e + ac_e <=> ac_c + h_c atp_c + amp_c <=> 2.0 adp_c coa_c + akg_c + nad_c --> nadh_c + co2_c + succoa_c akg_e + h_e <=> akg_c + h_c nad_c + etoh_c <=> nadh_c + h_c + acald_c atp_c + h2o_c --> h_c + adp_c + pi_c pi_c + 4.0 h_e + adp_c <=> atp_c + h2o_c + 3.0 h_c 0.2557 gln__L_c + 59.81 atp_c + 59.81 h2o_c + 1.496 3pg_c + 2.8328 pyr_c + 4.9414 glu__L_c + 3.7478 accoa_c + 0.8977 r5p_c + 0.205 g6p_c + 3.547 nad_c + 1.7867 oaa_c + 0.129 g3p_c + 13.0279 nadph_c + 0.5191 pep_c + 0.361 e4p_c + 0.0709 f6p_c --> 13.0279 nadp_c + 59.81 adp_c + 3.547 nadh_c + 59.81 pi_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c co2_e <=> co2_c oaa_c + accoa_c + h2o_c --> cit_c + h_c + coa_c 0.5 o2_c + 2.0 h_c + q8h2_c --> 2.0 h_e + h2o_c + q8_c h_e + lac__D_e <=> lac__D_c + h_c 2pg_c <=> h2o_c + pep_c h_e + etoh_e <=> h_c + etoh_c ac_e --> acald_e --> akg_e --> co2_e <=> etoh_e --> for_e --> fru_e --> fum_e --> glc__D_e <=> gln__L_e --> glu__L_e --> h2o_e <=> h_e <=> lac__D_e --> mal__L_e --> nh4_e <=> o2_e <=> pi_e <=> pyr_e --> succ_e --> fdp_c <=> g3p_c + dhap_c h2o_c + fdp_c --> f6p_c + pi_c h_e + for_e --> for_c + h_c for_c --> for_e fum_c + q8h2_c --> succ_c + q8_c fru_e + pep_c --> f6p_c + pyr_c h2o_c + fum_c <=> mal__L_c 2.0 h_e + fum_e --> fum_c + 2.0 h_c g6p_c + nadp_c <=> h_c + 6pgl_c + nadph_c pi_c + g3p_c + nad_c <=> nadh_c + 13dpg_c + h_c glc__D_e + pep_c --> g6p_c + pyr_c glu__L_c + atp_c + nh4_c --> gln__L_c + adp_c + pi_c + h_c atp_c + h2o_c + gln__L_e --> pi_c + adp_c + gln__L_c + h_c glu__L_c + nadp_c + h2o_c <=> nadph_c + h_c + akg_c + nh4_c h2o_c + gln__L_c --> glu__L_c + nh4_c gln__L_c + h_c + akg_c + nadph_c --> 2.0 glu__L_c + nadp_c h_e + glu__L_e <=> glu__L_c + h_c 6pgc_c + nadp_c --> ru5p__D_c + co2_c + nadph_c h2o_e <=> h2o_c icit_c + nadp_c <=> akg_c + co2_c + nadph_c icit_c --> succ_c + glx_c nad_c + lac__D_c <=> nadh_c + h_c + pyr_c glx_c + accoa_c + h2o_c --> coa_c + mal__L_c + h_c mal__L_e + 2.0 h_e --> mal__L_c + 2.0 h_c mal__L_c + nad_c <=> nadh_c + oaa_c + h_c mal__L_c + nad_c --> nadh_c + co2_c + pyr_c mal__L_c + nadp_c --> co2_c + pyr_c + nadph_c nadh_c + 4.0 h_c + q8_c --> 3.0 h_e + nad_c + q8h2_c nad_c + nadph_c --> nadh_c + nadp_c nh4_e <=> nh4_c o2_e <=> o2_c nad_c + coa_c + pyr_c --> nadh_c + co2_c + accoa_c atp_c + f6p_c --> h_c + adp_c + fdp_c coa_c + pyr_c --> accoa_c + for_c g6p_c <=> f6p_c atp_c + 3pg_c <=> adp_c + 13dpg_c h2o_c + 6pgl_c --> 6pgc_c + h_c 2pg_c <=> 3pg_c pi_e + h_e <=> pi_c + h_c pep_c + h2o_c + co2_c --> pi_c + oaa_c + h_c atp_c + oaa_c --> co2_c + adp_c + pep_c atp_c + h2o_c + pyr_c --> pi_c + pep_c + 2.0 h_c + amp_c accoa_c + pi_c <=> actp_c + coa_c h_c + adp_c + pep_c --> atp_c + pyr_c pyr_e + h_e <=> h_c + pyr_c ru5p__D_c <=> xu5p__D_c r5p_c <=> ru5p__D_c 2.0 h_e + succ_e --> succ_c + 2.0 h_c succ_c + h_e --> succ_e + h_c succ_c + q8_c --> fum_c + q8h2_c succ_c + coa_c + atp_c <=> adp_c + pi_c + succoa_c g3p_c + s7p_c <=> e4p_c + f6p_c 2.0 h_e + nadp_c + nadh_c --> 2.0 h_c + nad_c + nadph_c r5p_c + xu5p__D_c <=> g3p_c + s7p_c e4p_c + xu5p__D_c <=> g3p_c + f6p_c dhap_c <=> g3p_c

Other accepted formats include pickle (simply pickled models) and json.

Import models from the internet

In the previous quick start chapter we demonstrated how to use ~cameo.io.load_model to import a model by ID. But where did the model come from? Cameo has currently access to two model repositories on the internet, http://bigg.ucsd.edu and http://darwin.di.uminho.pt/models.

from cameo import models

models.index_models_bigg()

	bigg_id	gene_count	metabolite_count	organism	reaction_count
0	e_coli_core	137	72	Escherichia coli str. K-12 substr. MG1655	95
1	iAB_RBC_283	346	342	Homo sapiens	469
2	iAF1260	1261	1668	Escherichia coli str. K-12 substr. MG1655	2382
3	iAF1260b	1261	1668	Escherichia coli str. K-12 substr. MG1655	2388
4	iAF692	692	628	Methanosarcina barkeri str. Fusaro	690
5	iAF987	987	1109	Geobacter metallireducens GS-15	1285
6	iAPECO1_1312	1313	1944	Escherichia coli APEC O1	2736
...	...	...	...	...	...
72	iWFL_1372	1372	1975	Escherichia coli W	2783
73	iY75_1357	1358	1953	Escherichia coli str. K-12 substr. W3110	2760
74	iYL1228	1229	1658	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	2262
75	iYO844	844	991	Bacillus subtilis subsp. subtilis str. 168	1250
76	iZ_1308	1308	1923	Escherichia coli O157:H7 str. EDL933	2722
77	RECON1	1905	2766	Homo sapiens	3742
78	STM_v1_0	1271	1802	Salmonella enterica subsp. enterica serovar Ty...	2545

79 rows × 5 columns

models.index_models_minho()

	id	name	doi	author	year	formats	organism	taxonomy	validated
0	1	iJR904	10.1186/gb-2003-4-9-r54	Reed	2003	[sbml]	Escherichia coli str. K12 substr. MG1655	Bacteria; Proteobacteria; Gammaproteobacteria;...	True
1	2	iAF1260	10.1038/msb4100155	Feist	2007	[sbml]	Escherichia coli str. K12 substr. MG1655	Bacteria; Proteobacteria; Gammaproteobacteria;...	True
2	3	iMM904	10.1186/1752-0509-3-37	Mo	2007	[sbml]	Saccharomyces cerevisiae	Eukaryota; Opisthokonta; Fungi; Dikarya; Ascom...	True
3	4	iJP815	10.1371/journal.pcbi.1000210	Puchalka	2008	[sbml]	Pseudomonas putida str. KT2440	Bacteria; Proteobacteria; Gammaproteobacteria;...	True
4	5	iMO1056	10.1128/JB.01583-07	Oberhardt	2008	[excel]	Pseudomonas aeruginosa str. PAO1	Bacteria; Proteobacteria; Gammaproteobacteria;...	False
5	6	iIN800	10.1186/1752-0509-2-71	Nookaew	2008	[sbml]	Saccharomyces cerevisiae	Eukaryota; Opisthokonta; Fungi; Dikarya; Ascom...	False
6	7	iFF708	10.1101/gr.234503	Förster	2003	[sbml]	Saccharomyces cerevisiae str. Sc288	Eukaryota; Opisthokonta; Fungi; Dikarya; Ascom...	False
...	...	...	...	...	...	...	...	...	...
136	141	iMM518	10.1039/c3mb70421a	N. Goyal	2014	[excel]	Methanococcus maripaludis S2	Archaea; Euryarchaeota; Methanococci; Methanoc...	False
137	142	iPC1209	10.1016/j.febslet.2014.12.010	Cheng Wang	2015	[]	Pectobacterium carotovorum subsp. carotovorum PC1	Bacteria; Proteobacteria; Gammaproteobacteria;...	False
138	143	iNV706	10.1128/AEM.03279-14	N. Veith	2014	[]	Enterococcus faecalis V583	Bacteria; Firmicutes; Bacilli; Lactobacillales...	False
139	144	KoxGSC1457	10.1186/1475-2859-12-20	J. Park	2013	[]	Klebsiella oxytoca	Bacteria; Proteobacteria; Gammaproteobacteria;...	False
140	145	iJL846	10.1016/j.gene.2014.10.034	Jie Liu	2015	[]	Lactobacillus casei LC2W	Bacteria; Firmicutes; Bacilli; Lactobacillales...	False
141	146	yeast 7.6	10.1089/ind.2013.0013	Aung (updated)	2015	[sbml]	Yeast	Eukaryota; Opisthokonta; Fungi;	False
142	147	iJK849	10.1111/tpj.13081	Joomi Kim	2015	[sbml, excel]	Phaeodactylum tricornutum	Eukaryota; Stramenopiles; Bacillariophyta; Bac...	True

143 rows × 9 columns

Models from BiGG and the University of Minho can conveniently be accessd via ~cameo.models.bigg and ~cameo.models.minho respectively.

models.bigg.iJN746

Name	iJN746
Number of metabolites	909
Number of reactions	1056
Reactions	cit_e --> co2_e <=> nadph_c + h_c + 1pipdn2c_c --> nadp_c + Lpipecol_c atp_c + 2.0 h_c + 2dhglcn_c --> 6p2dhglcn_c + adp_c 2dhglcn_p + h_p --> h_c + 2dhglcn_c 2dhglcn_e <=> 2dhglcn_p 34dhcinm_e <=> 34dhcinm_p 34dhcinm_p <=> 34dhcinm_c 34hpp_c + o2_c --> co2_c + hgentis_c 3hdecACP_c + coa_c <=> R_3hdcoa_c + ACP_c 3hddecACP_c + coa_c <=> R_3hddcoa_c + ACP_c 3hcddec5eACP_c + coa_c <=> ACP_c + R_3hcddec5ecoa_c 3hmrsACP_c + coa_c <=> R_3hmrscoa_c + ACP_c 3hcmrs7eACP_c + coa_c <=> R_3hcmrs7ecoa_c + ACP_c 3hhexACP_c + coa_c <=> R_3hhcoa_c + ACP_c 3hoctACP_c + coa_c <=> R_3hocoa_c + ACP_c 3hdecACP_c --> tdec2eACP_c + h2o_c 3hddecACP_c --> h2o_c + tddec2eACP_c 3hcddec5eACP_c --> t3c5ddeceACP_c + h2o_c 3hmrsACP_c --> tmrs2eACP_c + h2o_c 3hcmrs7eACP_c --> h2o_c + t3c7mrseACP_c 3hpalmACP_c --> h2o_c + tpalm2eACP_c 3hcpalm9eACP_c --> h2o_c + t3c9palmeACP_c 3hoctaACP_c --> toctd2eACP_c + h2o_c 3hcvac11eACP_c --> h2o_c + t3c11vaceACP_c 3haACP_c --> but2eACP_c + h2o_c 3hhexACP_c --> h2o_c + thex2eACP_c 3hoctACP_c --> h2o_c + toct2eACP_c 3hibutcoa_c + h2o_c --> 3hmp_c + h_c + coa_c 3mbzalc_c + nad_c --> 3mbzald_c + nadh_c + h_c 3mbzald_c + nad_c + h2o_c --> m_tol_c + nadh_c + 2.0 h_c 3mcat_c + o2_c --> h_c + cchoxod_c 3oxoadp_c + succoa_c --> oxadpcoa_c + succ_c nadph_c + h_c + 3odecACP_c <=> nadp_c + 3hdecACP_c 3oddecACP_c + nadph_c + h_c <=> nadp_c + 3hddecACP_c nadph_c + 3ocddec5eACP_c + h_c --> nadp_c + 3hcddec5eACP_c nadph_c + h_c + 3omrsACP_c <=> nadp_c + 3hmrsACP_c nadph_c + h_c + 3ocmrs7eACP_c --> 3hcmrs7eACP_c + nadp_c nadph_c + h_c + 3opalmACP_c <=> nadp_c + 3hpalmACP_c nadph_c + 3ocpalm9eACP_c + h_c --> 3hcpalm9eACP_c + nadp_c nadph_c + h_c + 3ooctdACP_c <=> nadp_c + 3hoctaACP_c 3ocvac11eACP_c + nadph_c + h_c --> 3hcvac11eACP_c + nadp_c nadph_c + actACP_c + h_c <=> 3haACP_c + nadp_c nadph_c + h_c + 3ohexACP_c <=> nadp_c + 3hhexACP_c nadph_c + 3ooctACP_c + h_c <=> nadp_c + 3hoctACP_c ocACP_c + h_c + malACP_c --> co2_c + 3odecACP_c + ACP_c dcaACP_c + h_c + malACP_c --> co2_c + ACP_c + 3oddecACP_c cdec3eACP_c + h_c + malACP_c --> co2_c + ACP_c + 3ocddec5eACP_c ddcaACP_c + h_c + malACP_c --> co2_c + ACP_c + 3omrsACP_c cddec5eACP_c + h_c + malACP_c --> co2_c + 3ocmrs7eACP_c + ACP_c h_c + myrsACP_c + malACP_c --> co2_c + 3opalmACP_c + ACP_c tdeACP_c + h_c + malACP_c --> co2_c + ACP_c + 3ocpalm9eACP_c palmACP_c + h_c + malACP_c --> co2_c + ACP_c + 3ooctdACP_c h_c + malACP_c + hdeACP_c --> co2_c + ACP_c + 3ocvac11eACP_c butACP_c + h_c + malACP_c --> co2_c + 3ohexACP_c + ACP_c hexACP_c + h_c + malACP_c --> co2_c + ACP_c + 3ooctACP_c oxadpcoa_c + coa_c --> accoa_c + succoa_c 3oxoadp_e <=> 3oxoadp_p 3oxoadp_p + h_p <=> 3oxoadp_c + h_c 34dhbz_p + h_p <=> 34dhbz_c + h_c 34dhbz_e <=> 34dhbz_p atp_c + T4hcinnm_c + coa_c --> amp_c + ppi_c + 4cmcoa_c h_c + 4cml_c --> 5odhf2a_c + co2_c nadph_c + o2_c + 4hbz_c + h_c --> nadp_c + 34dhbz_c + h2o_c 4hbz_e <=> 4hbz_p phthr_c + h2o_c --> pi_c + 4hthr_c 4mbzalc_c + nad_c --> 4mbzald_c + nadh_c + h_c nad_c + 4mbzald_c + h2o_c --> p_tol_c + nadh_c + 2.0 h_c 4mcat_c + o2_c --> h_c + hmccms_c h_c + oxalc_c --> co2_c + op4en_c h_c + 2omcm_c --> co2_c + 2hchd_c 2hmc_c <=> oxalc_c hmccm_c <=> 2omcm_c chols_e --> 6hnac_c + o2_c + nadh_c + 2.0 h_c --> co2_c + dhpyr_c + nad_c + h2o_c thp2c_c + h_c + h2o_c <=> L2aadp6sa_c nad_c + L2aadp6sa_c + h2o_c --> L2aadp_c + 2.0 h_c + nadh_c glu__L_c + 2oxoadp_c <=> akg_c + L2aadp_c 4abut_c + akg_c <=> sucsal_c + glu__L_c 4abut_p + h_p --> 4abut_c + h_c 4abut_e <=> 4abut_p 2.0 accoa_c <=> aacoa_c + coa_c nad_c + acald_c + coa_c <=> h_c + nadh_c + accoa_c adocbip_c + h_c + gtp_c --> ppi_c + agdpcbi_c atp_c + accoa_c + hco3_c <=> malcoa_c + pi_c + h_c + adp_c atp_c + acglu_c --> acg5p_c + adp_c accoa_c + glu__L_c --> coa_c + h_c + acglu_c 2obut_c + pyr_c + h_c --> co2_c + 2ahbut_c ac_c + atp_c <=> actp_c + adp_c 2.0 pyr_c + h_c --> co2_c + alac__S_c btcoa_c + fad_c <=> b2coa_c + fadh2_c hxcoa_c + fad_c <=> hx2coa_c + fadh2_c occoa_c + fad_c <=> oc2coa_c + fadh2_c dcacoa_c + fad_c <=> dc2coa_c + fadh2_c ddcacoa_c + fad_c <=> dd2coa_c + fadh2_c tdcoa_c + fad_c <=> fadh2_c + td2coa_c pmtcoa_c + fad_c <=> hdd2coa_c + fadh2_c 2mbcoa_c + fad_c --> 2mb2coa_c + fadh2_c 2.0 ibcoa_c + o2_c --> 2.0 2mp2coa_c + 2.0 h2o_c accoa_c + ACP_c <=> acACP_c + coa_c h2o_c + acorn_c --> ac_c + orn_c acon_C_e <=> acon_C_p cit_c <=> icit_c cit_c <=> h2o_c + acon_C_c h2o_c + acon_C_c <=> icit_c acorn_c + akg_c <=> acg5sa_c + glu__L_c atp_c + ppa_c + coa_c --> ppcoa_c + amp_c + ppi_c ac_c + atp_c + coa_c <=> amp_c + ppi_c + accoa_c ac_p + h_p --> ac_c + h_c ac_e <=> ac_p adn_c + h_c + h2o_c --> nh4_c + ins_c 4adcho_c --> pyr_c + h_c + 4abz_c appl_c + atp_c + adcobhex_c --> pi_c + adocbi_c + h_c + adp_c applp_c + atp_c + adcobhex_c --> adocbip_c + pi_c + h_c + adp_c 4.0 gln__L_c + 4.0 atp_c + adcobdam_c + 4.0 h2o_c --> 4.0 pi_c + 4.0 glu__L_c + 4.0 h_c + 4.0 adp_c + adcobhex_c amp_c + atp_c <=> 2.0 adp_c atp_c --> ppi_c + camp_c atp_c + adocbi_c --> h_c + adp_c + adocbip_c rdmbzi_c + agdpcbi_c --> gmp_c + h_c + adocbl_c prpp_c + ade_c --> ppi_c + amp_c ppi_c + aicar_c <=> prpp_c + C04051_c dcamp_c <=> amp_c + fum_c 25aics_c <=> fum_c + aicar_c atp_c + asp__L_c --> 4pasp_c + adp_c asp__L_c + gtp_c + imp_c --> pi_c + 2.0 h_c + dcamp_c + gdp_c agm_c + h2o_c --> urea_c + ptrc_c ddcaACP_c + 1ddecg3p_c --> ACP_c + pa120_c 1hdecg3p_c + palmACP_c --> pa160_c + ACP_c 1hdec9eg3p_c + hdeACP_c --> pa161_c + ACP_c 1odecg3p_c + ocdcaACP_c --> pa180_c + ACP_c octeACP_c + 1odec11eg3p_c --> ACP_c + pa181_c acg5sa_c + nadp_c + pi_c <=> nadph_c + h_c + acg5p_c 10fthf_c + aicar_c <=> fprica_c + thf_c co2_c + air_c <=> 5aizc_c + h_c akg_c + nad_c + coa_c --> co2_c + nadh_c + succoa_c akg_c + h_c + lpam_c <=> co2_c + sdhlam_c sdhlam_c + coa_c <=> dhlam_c + succoa_c akg_p + h_p <=> akg_c + h_c akg_e <=> akg_p 2.0 ala__D_c + atp_c <=> pi_c + alaala_c + h_c + adp_c ala__L_c <=> ala__D_c akg_c + ala__L_c <=> glu__L_c + pyr_c atp_c + ala__L_c + trnaala_c --> alatrna_c + amp_c + ppi_c ala__L_e <=> ala__L_p glyald_c + nadh_c + h_c <=> nad_c + glyc_c nadh_c + h_c + acald_c --> nad_c + etoh_c pqq_c + etoh_c --> pqqh2_c + acald_c nad_c + acald_c + h2o_c --> ac_c + nadh_c + 2.0 h_c nad_c + acald_c + h2o_c <=> ac_c + nadh_c + 2.0 h_c air_c + nad_c + h2o_c --> 2.0 for_c + 4ampm_c + nadh_c + 3.0 h_c amp_c + h2o_c --> r5p_c + ade_c prpp_c + anth_c --> pran_c + ppi_c chor_c + gln__L_c --> pyr_c + glu__L_c + anth_c + h_c 6a2ohxnt_c <=> 1pipdn2c_c + h2o_c ap4a_c + h2o_c --> 2.0 h_c + 2.0 adp_c 5apentam_c + h2o_c --> 5aptn_c + nh3_c 5apru_c + nadph_c + h_c --> nadp_c + 5aprbu_c aps_c + trdrd_c --> amp_c + trdox_c + 2.0 h_c + so3_c akg_c + 5aptn_c <=> oxptn_c + glu__L_c arg__L_c + h2o_c --> nh4_c + citr__L_c arg__L_c + h_c --> co2_c + agm_c orn_c + arg__L_p <=> orn_p + arg__L_c argsuc_c <=> fum_c + arg__L_c asp__L_c + atp_c + citr__L_c --> ppi_c + amp_c + argsuc_c + h_c arg__L_c + atp_c + trnaarg_c --> argtrna_c + amp_c + ppi_c atp_c + arg__L_p + h2o_c --> pi_c + arg__L_c + h_c + adp_c arg__L_e <=> arg__L_p pyr_c + arg__L_c <=> oxoarg__L_c + ala__L_c nadph_c + 4pasp_c + h_c --> nadp_c + pi_c + aspsa_c h2o_c + asn__L_c --> asp__L_c + nh4_c gln__L_c + asp__L_c + atp_c + h2o_c --> glu__L_c + asn__L_c + amp_c + ppi_c + h_c asp__L_c + cbp_c --> pi_c + cbasp_c + h_c asp__L_c + o2_c + h2o_c --> h2o2_c + nh4_c + oaa_c asp__L_c + o2_c --> iasp_c + h_c + h2o2_c asp__L_c --> fum_c + nh4_c akg_c + asp__L_c <=> oaa_c + glu__L_c atp_c + asp__L_c + trnaasp_c --> amp_c + asptrna_c + ppi_c atp_c + h2o_c + asp__L_p --> pi_c + asp__L_c + adp_c + h_c 2.0 h_p + asp__L_p --> asp__L_c + 2.0 h_c asp__L_e <=> asp__L_p arg__L_c + succoa_c --> sucarg_c + h_c + coa_c prpp_c + atp_c <=> prbatp_c + ppi_c pi_c + 4.0 h_p + adp_c <=> atp_c + 3.0 h_c + h2o_c nad_c + bhb_c <=> h_c + nadh_c + acac_c betald_c + nad_c + h2o_c --> glyb_c + nadh_c + 2.0 h_c hcys__L_c + glyb_c --> dmgly_c + met__L_c bz_c + o2_c + nadh_c + h_c --> nad_c + bz12diol_c nad_c + bzalc_c --> bzal_c + nadh_c + h_c bzal_c + nad_c + h2o_c --> bz_c + nadh_c + 2.0 h_c nad_c + bz12diol_c --> co2_c + nadh_c + catechol_c h_p + bz_p <=> bz_c + h_c bz_e <=> bz_p 0.229 asp__L_c + 0.582 gly_c + 0.488 ala__L_c + 0.0005 pe120_c + 0.0005 pe181_c + 0.136 utp_c + 0.0004 nadph_c + 0.402 val__L_c + 0.0254 dctp_c + 0.326 lys__L_c + 0.087 cys__L_c + 0.0005 pg120_c + 0.25 glu__L_c + 0.0005 pg160_c + 0.0005 pg180_c + 0.428 leu__L_c + 0.276 ile__L_c + 0.176 phe__L_c + 0.001 amp_c + 0.21 pro__L_c + 0.146 met__L_c + 0.229 asn__L_c + 0.0247 dttp_c + 0.00215 nad_c + 0.0247 datp_c + 0.0005 cpg180_c + 0.126 ctp_c + 0.0005 sheme_c + 1e-05 fad_c + 0.003 udpg_c + 0.131 tyr__L_c + 0.09 his__L_c + 0.0005 hemeO_c + 0.054 trp__L_c + 0.241 thr__L_c + 0.0005 cpe180_c + 0.05 5mthf_c + 45.7318 atp_c + 5e-05 accoa_c + 3e-06 succoa_c + 0.0005 pe180_c + 45.5608 h2o_c + 0.25 gln__L_c + 0.0005 pe161_c + 0.203 gtp_c + 0.00013 nadp_c + 0.205 ser__L_c + 0.0005 cpe160_c + 0.0005 cpg160_c + 6e-06 coa_c + 0.281 arg__L_c + 0.0005 pe160_c + 5e-05 nadh_c + 0.0254 dgtp_c + 0.035 ptrc_c --> 0.7302 ppi_c + 45.5608 adp_c + 45.56035 h_c + 45.5628 pi_c caffcoa_c + h2o_c --> accoa_c + 34dhbald_c 34dhcinm_c + atp_c + coa_c --> caffcoa_c + amp_c + ppi_c 2.0 h2o2_c --> o2_c + 2.0 h2o_c o2_c + catechol_c --> 2hmcnsad_c o2_c + catechol_c --> ccmuac_c + 2.0 h_c catechol_e <=> catechol_p catechol_p <=> catechol_c co2_c + atp_c + nh4_c <=> cbp_c + 2.0 h_c + adp_c gln__L_c + 2.0 atp_c + hco3_c + h2o_c --> pi_c + glu__L_c + cbp_c + 2.0 h_c + 2.0 adp_c atp_c + 4c2me_c --> 2p4c2me_c + h_c + adp_c pe161_c + 2.0 amet_c --> 2.0 h_c + cpe160_c + 2.0 ahcys_c pg161_c + 2.0 amet_c --> cpg160_c + 2.0 h_c + 2.0 ahcys_c 2.0 amet_c + pe181_c --> cpe180_c + 2.0 ahcys_c + 2.0 h_c 2.0 amet_c + pg181_c --> cpg180_c + 2.0 h_c + 2.0 ahcys_c atp_c + chol_p + h2o_c --> pi_c + chol_c + h_c + adp_c h_p + chol_p --> chol_c + h_c chol_e <=> chol_p chol_c + nad_c --> nadh_c + h_c + betald_c chols_c + h2o_c --> h_c + chol_c + so4_c chols_e <=> chols_p 26dap_LL_c <=> 26dap__M_c chols_p + atp_c + h2o_c --> chols_c + pi_c + h_c + adp_c chor_c --> pphn_c 3psme_c --> chor_c + pi_c cit_p + h_p <=> h_c + cit_c cit_e <=> cit_p 2.0 pg120_p <=> glyc_p + clpn120_p 2.0 pg160_p <=> clpn160_p + glyc_p 2.0 pg161_p <=> clpn161_p + glyc_p 2.0 pg180_p <=> clpn180_p + glyc_p 2.0 pg181_p <=> glyc_p + clpn181_p co2_e <=> co2_p co2_p <=> co2_c nad_c + confrl_c --> conialdh_c + nadh_c + h_c conialdh_c + nad_c + h2o_c --> fer_c + nadh_c + 2.0 h_c cobalt2_e <=> cobalt2_p cobalt2_p --> cobalt2_c hgbam_c + atp_c + cobalt2_c + h2o_c --> pi_c + 2.0 h_c + co2dam_c + adp_c h2o_c + 4cmcoa_c --> accoa_c + 4hbald_c confrl_e <=> confrl_p confrl_p <=> confrl_c cpppg3_c + o2_c + 2.0 h_c --> 2.0 co2_c + pppg9_c + 2.0 h2o_c cpppg3_c + 2.0 amet_c --> 2.0 co2_c + 2.0 met__L_c + pppg9_c + 2.0 dad_5_c atp_c + crn_p + h2o_c --> crn_c + pi_c + h_c + adp_c crn_e <=> crn_p accoa_c + oaa_c + h2o_c --> cit_c + h_c + coa_c csn_c + h_c + h2o_c --> nh4_c + ura_c utp_c + gln__L_c + atp_c + h2o_c --> glu__L_c + ctp_c + 2.0 h_c + pi_c + adp_c 2.0 ficytc_c + q8h2_c + 2.0 h_c --> q8_c + 2.0 focytc_c + 2.0 h_p 0.5 o2_c + 2.0 focytc_c --> h2o_c + 2.0 ficytc_c co1dam_c + atp_c + h_c --> adcobdam_c + pppi_c nadh_c + 2.0 co2dam_c --> 2.0 co1dam_c + nad_c + h_c h2s_c + acser_c --> ac_c + h_c + cys__L_c tsul_c + acser_c --> ac_c + scys__L_c cyst__L_c + h2o_c <=> cys__L_c + 2obut_c + nh4_c cyst__L_c + h2o_c --> hcys__L_c + pyr_c + nh4_c cys__L_c + atp_c + trnacys_c --> amp_c + cystrna_c + ppi_c cys__L_p + atp_c + h2o_c --> cys__L_c + pi_c + h_c + adp_c cys__L_e <=> cys__L_p q8h2_c + 0.5 o2_c + 2.0 h_c --> q8_c + 2.0 h_p + h2o_c q8h2_c + 0.5 o2_c + 4.0 h_c --> q8_c + 4.0 h_p + h2o_c cmp_c + atp_c <=> cdp_c + adp_c dcmp_c + atp_c <=> dcdp_c + adp_c ala__D_c + h2o_c + fad_c --> pyr_c + nh4_c + fadh2_c 24dab_c + akg_c + 2.0 h_c <=> aspsa_c + glu__L_c dad_2_c + h_c + h2o_c --> din_c + nh4_c damp_c + atp_c <=> dadp_c + adp_c akg_c + 15dap_c --> glu__L_c + pprdn_c + h_c + h2o_c 26dap__M_c + h_c --> co2_c + lys__L_c ctp_c + h_c + pa120_c --> ppi_c + cdpdddecg_c pa160_c + ctp_c + h_c --> cdpdhdecg_c + ppi_c ctp_c + pa161_c + h_c --> ppi_c + cdpdhdec9eg_c ctp_c + pa180_c + h_c --> ppi_c + cdpdodecg_c ctp_c + h_c + pa181_c --> ppi_c + cdpdodec11eg_c ru5p__D_c --> db4p_c + h_c + for_c dca_e <=> dca_p dctp_c + h_c + h2o_c --> dutp_c + nh4_c ctp_c + h_c + h2o_c --> utp_c + nh4_c ddca_e <=> ddca_p pep_c + h2o_c + e4p_c --> pi_c + 2dda7p_c dgmp_c + atp_c <=> dgdp_c + adp_c nad_c + dh3mchc_c --> co2_c + 3mcat_c + nadh_c dh4mchc_c + nad_c --> co2_c + 4mcat_c + nadh_c 23dhmb_c --> 3mob_c + h2o_c 23dhmp_c --> 3mop_c + h2o_c 23dhdp_c + nadph_c + h_c --> nadp_c + thdp_c pyr_c + aspsa_c --> 23dhdp_c + h_c + 2.0 h2o_c nadph_c + h_c + dhf_c <=> nadp_c + thf_c atp_c + glu__L_c + dhpt_c --> pi_c + dhf_c + h_c + adp_c dhnpt_c --> 2ahhmp_c + gcald_c + h_c o2_c + dhor__S_c <=> orot_c + h2o2_c dhor__S_c + h2o_c <=> cbasp_c + h_c 2dhphaccoa_c + 2.0 h2o_c + coa_c --> 3hadpcoa_c + h2_c + accoa_c + h_c h2o_c + 56dura_c --> cala_c + h_c h_c + 25dhpp_c + h2o_c --> 5apru_c + nh4_c dhbpt_c + nadh_c + h_c --> thbpt_c + nad_c 4abz_c + 2ahhmp_c --> dhpt_c + h2o_c 3dhq_c <=> 3dhsk_c + h2o_c 2dda7p_c --> pi_c + 3dhq_c 3dhsk_c --> 34dhbz_c + h2o_c akg_c + lys__D_c <=> glu__D_c + 6a2ohxnt_c pyr_c + lys__D_c <=> ala__D_c + 6a2ohxnt_c dmpp_c + ipdp_c --> ppi_c + grdp_c dmgly_c + h2o_c + fad_c <=> fadh2_c + sarcs_c + fald_c aacald_c --> C100mclPHA_c --> C120mclPHA_c --> C121mclPHA_c --> C140mclPHA_c --> C141mclPHA_c --> C60mclPHA_c --> C80mclPHA_c --> dad_5_c --> fald_c --> mclPHA_c --> ptal_c --> amet_c + dna_c <=> ahcys_c + dna5mtc_c + h_c dhpmp_c + h2o_c --> pi_c + dhnpt_c ahdt_c + h2o_c --> ppi_c + h_c + dhpmp_c dpcoa_c + atp_c --> h_c + adp_c + coa_c C100mclPHA_c + coa_c --> R_3hdcoa_c + mclPHAg_c C120mclPHA_c + coa_c --> R_3hddcoa_c + mclPHAg_c C121mclPHA_c + coa_c --> R_3hcddec5ecoa_c + mclPHAg_c C140mclPHA_c + coa_c --> R_3hmrscoa_c + mclPHAg_c C141mclPHA_c + coa_c --> R_3hcmrs7ecoa_c + mclPHAg_c C60mclPHA_c + coa_c --> R_3hhcoa_c + mclPHAg_c C80mclPHA_c + coa_c --> R_3hocoa_c + mclPHAg_c nadph_c + h_c + 2dhp_c --> nadp_c + pant__R_c dtmp_c + atp_c <=> dtdp_c + adp_c nadp_c + 56dura_c <=> nadph_c + h_c + ura_c h2o_c + dutp_c --> dump_c + ppi_c + h_c nadph_c + h_c + dxyl5p_c --> nadp_c + 2me4p_c g3p_c + pyr_c + h_c --> co2_c + dxyl5p_c h_p + lac__D_p <=> lac__D_c + h_c lac__D_e <=> lac__D_p nad_c + e4p_c + h2o_c <=> 4per_c + nadh_c + 2.0 h_c tdec2eACP_c + nadph_c + h_c --> nadp_c + dcaACP_c nadph_c + h_c + tddec2eACP_c --> nadp_c + ddcaACP_c t3c5ddeceACP_c + nadph_c + h_c --> nadp_c + cddec5eACP_c tmrs2eACP_c + nadph_c + h_c --> nadp_c + myrsACP_c nadph_c + t3c7mrseACP_c + h_c --> nadp_c + tdeACP_c nadph_c + h_c + tpalm2eACP_c --> nadp_c + palmACP_c nadph_c + h_c + t3c9palmeACP_c --> nadp_c + hdeACP_c toctd2eACP_c + nadph_c + h_c --> nadp_c + ocdcaACP_c nadph_c + h_c + t3c11vaceACP_c --> octeACP_c + nadp_c nadph_c + but2eACP_c + h_c --> nadp_c + butACP_c nadph_c + h_c + thex2eACP_c --> nadp_c + hexACP_c nadph_c + h_c + toct2eACP_c --> nadp_c + ocACP_c 3hbcoa_c <=> b2coa_c + h2o_c 2mp2coa_c + h2o_c --> 3hibutcoa_c 3hhcoa_c <=> h2o_c + hx2coa_c 3hocoa_c <=> oc2coa_c + h2o_c 3hdcoa_c <=> dc2coa_c + h2o_c 3hddcoa_c <=> dd2coa_c + h2o_c 3htdcoa_c <=> h2o_c + td2coa_c 3hhdcoa_c <=> hdd2coa_c + h2o_c 2mb2coa_c + h2o_c --> 3hmbcoa_c 2ddg6p_c --> g3p_c + pyr_c 6pgc_c --> 2ddg6p_c + h2o_c 2pg_c <=> pep_c + h2o_c ethso3_p + atp_c + h2o_c --> pi_c + ethso3_c + h_c + adp_c ethso3_e <=> ethso3_p 2ddglcn_e --> 2dhglcn_e --> 34dhbz_e --> 34dhcinm_e --> 3oxoadp_e --> 4abut_e --> 4hbz_e --> T4hcinnm_e --> ac_e --> acon_C_e --> akg_e --> ala__L_e --> arg__L_e --> asp__L_e --> bz_e --> catechol_e --> chol_e --> cobalt2_e <=> confrl_e --> crn_e --> cys__L_e --> dca_e --> ddca_e --> ethso3_e --> fe2_e <=> fer_e --> fru_e --> fum_e --> ga_e --> glc__D_e <=> glcn_e --> glu__L_e --> gly_e --> glyald_e --> glyb_e --> glyc_e --> glyclt_e --> h2_e <=> h2o_e <=> h_e <=> hco3_e <=> hdca_e --> his__L_e --> hxa_e --> icit_e --> ile__L_e --> isetac_e --> lac__D_e --> lac__L_e --> leu__L_e --> lys__L_e --> m_xyl_e --> mal__L_e --> met__L_e --> mso3_e --> na1_e <=> nac_e --> nh4_e <=> ni2_e --> no2_e --> o2_e <=> octa_e --> orn_e --> p_xyl_e --> pac_e --> pentso3_e --> phe__L_e --> pi_e <=> pro__L_e --> ptrc_e --> quin_kt_e --> rib__D_e --> ser__L_e --> so4_e <=> spmd_e --> succ_e --> taur_e --> thr__L_e --> tol_e --> tsul_e --> ttdca_e --> tyr__L_e --> val__L_e --> vanln_e --> vanlt_e --> h_p + atp_c + dca_p + coa_c --> ppi_c + amp_c + h_c + dcacoa_c h_p + atp_c + ddca_p + coa_c --> amp_c + ddcacoa_c + ppi_c + h_c ttdca_p + h_p + atp_c + coa_c --> tdcoa_c + amp_c + ppi_c + h_c h_p + atp_c + hdca_p + coa_c --> amp_c + ppi_c + h_c + pmtcoa_c hxa_p + h_p + atp_c + coa_c --> hxcoa_c + amp_c + ppi_c + h_c h_p + atp_c + octa_p + coa_c --> amp_c + occoa_c + ppi_c + h_c 2.0 focytc_c + o2_c + 2.0 fald_c --> 2.0 for_c + 4.0 h_c + 2.0 cytcc_c fdp_c <=> g3p_c + dhap_c fdp_c + h2o_c --> pi_c + f6p_c fe2_c + ppp9_c --> 2.0 h_c + pheme_c h2o_c + ferulcoa_c --> accoa_c + vanln_c nad_c + for_c --> co2_c + nadh_c isetac_c + o2_c + fmnh2_c --> fmn_c + gcald_c + h_c + so3_c + h2o_c mso3_c + o2_c + fmnh2_c --> fmn_c + fald_c + h_c + so3_c + h2o_c ethso3_c + o2_c + fmnh2_c --> h2o_c + fmn_c + h_c + so3_c + acald_c pentso3_c + o2_c + fmnh2_c --> ptal_c + fmn_c + h_c + so3_c + h2o_c o2_c + taur_c + fmnh2_c --> fmn_c + aacald_c + h_c + so3_c + h2o_c atp_c + fe2_e + h2o_c --> fe2_c + pi_c + h_c + adp_c fe2_e <=> fe2_c fer_c + atp_c + coa_c --> ppi_c + amp_c + ferulcoa_c fer_e <=> fer_p fer_p <=> fer_c 10fthf_c + mettrna_c --> thf_c + fmettrna_c + h_c fmn_c + h_c + atp_c --> ppi_c + fad_c h_c + nadph_c + fmn_c --> fmnh2_c + nadp_c 4abz_c + 2ahhmd_c --> dhpt_c + ppi_c 2.0 h_c + forglu_c + h2o_c --> nh3_c + Nforglu_c atp_c + f1p_c <=> fdp_c + h_c + adp_c pep_c + fru_e --> pyr_c + f1p_c 10fthf_c + h2o_c --> thf_c + h_c + for_c fum_c + h2o_c <=> mal__L_c 4fumacac_c + h2o_c --> fum_c + h_c + acac_c fum_p + 2.0 h_p --> fum_c + 2.0 h_c fum_e <=> fum_p accoa_c + gam1p_c --> acgam1p_c + h_c + coa_c glu1sa_c --> 5aop_c ddcaACP_c + glyc3p_c --> 1ddecg3p_c + ACP_c palmACP_c + glyc3p_c --> 1hdecg3p_c + ACP_c glyc3p_c + hdeACP_c --> 1hdec9eg3p_c + ACP_c glyc3p_c + ocdcaACP_c --> 1odecg3p_c + ACP_c octeACP_c + glyc3p_c --> 1odec11eg3p_c + ACP_c fad_c + glyc3p_c --> fadh2_c + dhap_c nadp_c + glyc3p_c <=> nadph_c + h_c + dhap_c glu5sa_c <=> 1pyr5c_c + h_c + h2o_c glu5p_c + nadph_c + h_c --> pi_c + nadp_c + glu5sa_c g6p_B_c + nadp_c --> 6pgl_c + nadph_c + h_c nadp_c + g6p_c --> nadph_c + 6pgl_c + h_c g6p_c <=> g6p_B_c o2_c + ga_c --> 2.0 h_c + omaketo_c glcn_p + fad_c <=> 2dhglcn_p + fadh2_c utp_c + h_c + g1p_c <=> ppi_c + udpg_c pi_c + g3p_c + nad_c <=> 13dpg_c + nadh_c + h_c 10fthf_c + gar_c <=> thf_c + h_c + fgam_c atp_c + for_c + gar_c --> pi_c + fgam_c + h_c + adp_c ga_e <=> ga_p h_p + ga_p <=> h_c + ga_c gcald_c + nad_c + h2o_c --> glyclt_c + nadh_c + 2.0 h_c gdbtal_c + nad_c + h2o_c --> 4gudbutn_c + nadh_c + 2.0 h_c gln__L_c + f6p_c --> glu__L_c + gam6p_c ser__L_c + thf_c <=> mlthf_c + h2o_c + gly_c atp_c + gmp_c <=> gdp_c + adp_c glc__D_p + q8_c + h2o_p --> glcn_p + q8h2_c + h_p h_p + glcn_p <=> h_c + glcn_c glcn_e <=> glcn_p atp_c + glutar_c + coa_c --> pi_c + glutcoa_c + adp_c S_gtrdhdlp_c + coa_c --> dhlam_c + glutcoa_c glc__D_p + atp_c + h2o_c --> pi_c + glc__D_c + h_c + adp_c glc__D_e <=> glc__D_p atp_c + nh4_c + glu__L_c --> pi_c + gln__L_c + h_c + adp_c glutrna_gln_c + gln__L_c + atp_c + h2o_c --> pi_c + glu__L_c + glntrna_c + h_c + adp_c gln__L_c + atp_c + trnagln_c --> glntrna_c + amp_c + ppi_c atp_c + glu__L_c --> glu5p_c + adp_c cys__L_c + atp_c + glu__L_c --> pi_c + h_c + adp_c + glucys_c h_c + glu__L_c --> co2_c + 4abut_c nadp_c + glu__L_c + h2o_c <=> akg_c + nadph_c + nh4_c + h_c gln__L_c + h2o_c --> nh4_c + glu__L_c gln__L_c + prpp_c + h2o_c --> glu__L_c + ppi_c + pram_c glu__D_c <=> glu__L_c akg_c + nadph_c + gln__L_c + h_c --> nadp_c + 2.0 glu__L_c h_c + fad_c + glutcoa_c --> co2_c + fadh2_c + b2coa_c nadph_c + glutrna_c + h_c --> nadp_c + trnaglu_c + glu1sa_c atp_c + glu__L_c + trnaglu_c --> amp_c + ppi_c + glutrna_c glu__L_p + atp_c + h2o_c --> pi_c + glu__L_c + h_c + adp_c glu__L_p + na1_p --> na1_c + glu__L_c glu__L_e <=> glu__L_p 2.0 glx_c + h_c --> co2_c + 2h3oppan_c glyald_c + nad_c + h2o_c <=> nadh_c + 2.0 h_c + glyc__R_c glyald_e <=> glyald_p glyald_p <=> glyald_c glyb_p + atp_c + h2o_c --> pi_c + glyb_c + h_c + adp_c glyb_e <=> glyb_p glyc__R_c + atp_c --> 3pg_c + h_c + adp_c thf_c + gly_c + nad_c --> co2_c + nadh_c + nh4_c + mlthf_c h_p + glyclt_p <=> glyclt_c + h_c glyclt_e <=> glyclt_p co2_c + nadh_c + nh4_c + mlthf_c --> thf_c + gly_c + nad_c glyclt_c + o2_c --> glx_c + h2o2_c glyc_e <=> glyc_p glyc_c <=> glyc_p nadh_c + h_c + hpyr_c <=> nad_c + glyc__R_c atp_c + glyc_c --> h_c + glyc3p_c + adp_c trnagly_c + atp_c + gly_c --> amp_c + glytrna_c + ppi_c atp_c + h2o_c + gly_p <=> pi_c + gly_c + h_c + adp_c gly_e <=> gly_p xmp_c + gln__L_c + atp_c + h2o_c --> glu__L_c + gmp_c + amp_c + ppi_c + 2.0 h_c nadp_c + 6pgc_c --> co2_c + nadph_c + ru5p__D_c atp_c + glcn_c --> adp_c + h_c + 6pgc_c h2o_c + gsn_c --> rib__D_c + gua_c grdp_c + ipdp_c --> ppi_c + frdp_c nadph_c + gthox_c + h_c --> 2.0 gthrd_c + nadp_c 2.0 gthrd_c + h2o2_c <=> gthox_c + 2.0 h2o_c atp_c + gly_c + glucys_c --> gthrd_c + pi_c + h_c + adp_c h2o_c + gtp_c --> ahdt_c + h_c + for_c gtp_c + 3.0 h2o_c --> 25dhpp_c + for_c + ppi_c + 2.0 h_c gdptp_c + h2o_c <=> ppgpp_c + pi_c + h_c atp_c + gtp_c --> amp_c + h_c + gdptp_c gua_c + h_c + h2o_c --> xan_c + nh4_c prpp_c + gua_c --> ppi_c + gmp_c 4gudbutn_c + h2o_c --> 4abut_c + urea_c co2_c + h2o_c <=> h2co3_c hco3_c + h_c <=> h2co3_c h2o_e <=> h2o_p h2o_p <=> h2o_c h2_e <=> h2_p h2_p <=> h2_c nad_c + 3hbcoa_c --> aacoa_c + nadh_c + h_c nad_c + 3hhcoa_c --> 3ohcoa_c + nadh_c + h_c nad_c + 3hocoa_c --> nadh_c + h_c + 3oocoa_c nad_c + 3hdcoa_c --> 3odcoa_c + nadh_c + h_c 3hddcoa_c + nad_c --> 3oddcoa_c + nadh_c + h_c nad_c + 3htdcoa_c --> nadh_c + h_c + 3otdcoa_c nad_c + 3hhdcoa_c --> 3ohdcoa_c + h_c + nadh_c nad_c + 3hmbcoa_c <=> nadh_c + h_c + 2maacoa_c 3hadpcoa_c --> oxadpcoa_c + h2_c co2_c + h2o_c <=> hco3_c + h_c hco3_e + na1_e <=> na1_c + hco3_c hdca_e <=> hdca_p h2o_c + frdp_c + pheme_c --> ppi_c + hemeO_c atp_c + glc__D_c --> h_c + adp_c + g6p_c hgentis_c + o2_c --> h_c + 4mlacac_c nad_c + 3hmp_c --> mmtsa_c + nadh_c + h_c his__L_c --> urcan_c + nh4_c histd_c + 2.0 nad_c + h2o_c --> 2.0 nadh_c + 3.0 h_c + his__L_c h2o_c + hisp_c --> pi_c + histd_c atp_c + trnahis_c + his__L_c --> amp_c + histrna_c + ppi_c atp_c + his__L_p + h2o_c --> pi_c + h_c + adp_c + his__L_c his__L_e <=> his__L_p 4.0 ppbng_c + h2o_c --> hmbil_c + 4.0 nh4_c hmgcoa_c --> accoa_c + acac_c atp_c + 4ahmmp_c --> 4ampm_c + adp_c + h_c 2hmcnsad_c + nad_c + h2o_c --> nadh_c + 3.0 h_c + 2hmc_c nad_c + h2o_c + hmccms_c --> hmccm_c + 2.0 h_c + nadh_c h2o_c + 2hmcnsad_c --> op4en_c + 2.0 h_c + for_c h2o_c + hmccms_c --> 2hchd_c + h_c + for_c h2o_c + cchoxod_c --> ac_c + h_c + chpd_c 4h2opntn_c --> pyr_c + acald_c 4hoxoh_c --> pyr_c + ppal_c 4h2oxov_c --> pyr_c + acald_c 2ahhmp_c + atp_c --> amp_c + 2ahhmd_c + h_c hpyr_c <=> 2h3oppan_c hom__L_c + nad_c <=> nadh_c + h_c + aspsa_c accoa_c + hom__L_c <=> achms_c + coa_c atp_c + hom__L_c --> phom_c + h_c + adp_c imacp_c + glu__L_c <=> akg_c + hisp_c hxan_c + nad_c + h2o_c --> nadh_c + h_c + xan_c hxa_e <=> hxa_p prpp_c + hxan_c --> ppi_c + imp_c h_e <=> h_p nadp_c + icit_c <=> co2_c + akg_c + nadph_c h_p + icit_p <=> icit_c + h_c icit_e <=> icit_p icit_c --> glx_c + succ_c gln__L_c + prlp_c --> eig3p_c + glu__L_c + aicar_c + h_c eig3p_c --> imacp_c + h2o_c 2cpr5p_c + h_c --> co2_c + h2o_c + 3ig3p_c akg_c + ile__L_c <=> 3mop_c + glu__L_c atp_c + trnaile_c + ile__L_c --> amp_c + ppi_c + iletrna_c ile__L_p + atp_c + h2o_c --> pi_c + h_c + adp_c + ile__L_c ile__L_e <=> ile__L_p h2o_c + imp_c <=> fprica_c nad_c + h2o_c + imp_c --> xmp_c + nadh_c + h_c ins_c + h2o_c --> rib__D_c + hxan_c ipdp_c <=> dmpp_c h2mb4p_c + nadh_c + h_c --> nad_c + h2o_c + ipdp_c nad_c + 3c2hmp_c <=> nadh_c + h_c + 3c4mop_c 3c2hmp_c <=> 2ippm_c + h2o_c 2ippm_c + h2o_c <=> 3c3hmp_c accoa_c + 3mob_c + h2o_c --> 3c3hmp_c + h_c + coa_c atp_c + isetac_p + h2o_c --> pi_c + h_c + isetac_c + adp_c isetac_e <=> isetac_p 4izp_c + h2o_c --> h_c + forglu_c nadp_c + 23dhmb_c <=> nadph_c + alac__S_c + h_c nadph_c + h_c + 2ahbut_c <=> nadp_c + 23dhmp_c h_c + malACP_c + acACP_c --> co2_c + ACP_c + actACP_c accoa_c + h_c + malACP_c --> co2_c + actACP_c + coa_c aacoa_c + coa_c --> 2.0 accoa_c 3ohcoa_c + coa_c --> btcoa_c + accoa_c 3oocoa_c + coa_c --> accoa_c + hxcoa_c 3odcoa_c + coa_c --> occoa_c + accoa_c 3oddcoa_c + coa_c --> accoa_c + dcacoa_c 3otdcoa_c + coa_c --> ddcacoa_c + accoa_c 3ohdcoa_c + coa_c --> accoa_c + tdcoa_c lac__D_c + nad_c <=> pyr_c + nadh_c + h_c akg_c + leu__L_c <=> glu__L_c + 4mop_c atp_c + trnaleu_c + leu__L_c --> leutrna_c + amp_c + ppi_c atp_c + leu__L_p + h2o_c --> pi_c + adp_c + h_c + leu__L_c leu__L_e <=> leu__L_p o2_c + Lpipecol_c --> thp2c_c + h_c + h2o2_c h_c + lys__L_c --> co2_c + 15dap_c o2_c + lys__L_c --> co2_c + 5apentam_c + h_c + h2o_c lys__L_c <=> lys__D_c atp_c + lys__L_c + trnalys_c --> lystrna_c + amp_c + ppi_c atp_c + lys__L_p + h2o_c --> pi_c + h_c + adp_c + lys__L_c lys__L_e <=> lys__L_p q8_c + lac__L_c --> q8h2_c + pyr_c h_p + lac__L_p <=> lac__L_c + h_c lac__L_e <=> lac__L_p 4mlacac_c --> 4fumacac_c 2maacoa_c + coa_c --> ppcoa_c + accoa_c h_c + malACP_c --> co2_c + acACP_c male_c <=> fum_c h2o_c + malm_c --> male_c + nh3_c + h_c glx_c + accoa_c + h2o_c --> mal__L_c + h_c + coa_c mal__L_p + 2.0 h_p --> mal__L_c + 2.0 h_c mal__L_e <=> mal__L_p ivcoa_c + fad_c --> 3mb2coa_c + fadh2_c atp_c + hco3_c + 3mb2coa_c --> pi_c + 3mgcoa_c + h_c + adp_c 2mcit_c --> 2mcacn_c + h2o_c micit_c <=> pyr_c + succ_c ppcoa_c + oaa_c + h2o_c --> 2mcit_c + h_c + coa_c malcoa_c + ACP_c <=> malACP_c + coa_c mal__L_c + nad_c <=> oaa_c + nadh_c + h_c mal__L_c + q8_c --> q8h2_c + oaa_c mal__L_c + nad_c --> co2_c + pyr_c + nadh_c 2mecdp_c + h_c --> h2o_c + h2mb4p_c 2p4c2me_c --> cmp_c + 2mecdp_c ctp_c + h_c + 2me4p_c --> ppi_c + 4c2me_c h2s_c + achms_c <=> ac_c + hcys__L_c + h_c atp_c + h2o_c + met__L_c --> pi_c + amet_c + ppi_c met__L_c + h2o_c --> 2obut_c + ch4s_c + nh4_c 5mthf_c + hcys__L_c <=> thf_c + h_c + met__L_c atp_c + met__L_c + trnamet_c --> amp_c + mettrna_c + ppi_c atp_c + met__L_p + h2o_c --> pi_c + met__L_c + h_c + adp_c met__L_e <=> met__L_p 3mgcoa_c + h2o_c --> hmgcoa_c 2mcacn_c + h2o_c <=> micit_c mmtsa_c + nad_c + coa_c --> co2_c + ppcoa_c + nadh_c 3mob_c + mlthf_c + h2o_c --> thf_c + 2dhp_c mso3_p + atp_c + h2o_c --> mso3_c + pi_c + h_c + adp_c mso3_e <=> mso3_p 3.0 nadp_c + ch4s_c + 3.0 h2o_c <=> 3.0 nadph_c + mso3_c + 4.0 h_c methf_c + h2o_c <=> 10fthf_c + h_c nadp_c + mlthf_c <=> nadph_c + methf_c nadph_c + mlthf_c + 2.0 h_c --> 5mthf_c + nadp_c hcys__L_c + 5mthglu_c <=> thglu_c + met__L_c m_tol_c + h_c + o2_c + nadh_c --> nad_c + dh3mchc_c ccmuac_c + h_c <=> mucl_c h_c + CCbuttc_c --> 4cml_c mucl_c <=> 5odhf2a_c m_xyl_c + o2_c + nadh_c + h_c --> nad_c + 3mbzalc_c + h2o_c m_xyl_p <=> m_xyl_c m_xyl_e <=> m_xyl_p 0.5 o2_c + nac_c --> 6hnac_c h_p + nac_p <=> nac_c + h_c nac_e <=> nac_p q8_c + nadh_c + 4.0 h_c --> nad_c + q8h2_c + 3.0 h_p q8_c + nadh_c + h_c --> nad_c + q8h2_c nad_c + atp_c --> nadp_c + h_c + adp_c q8_c + nadph_c + h_c --> nadp_c + q8h2_c dnad_c + atp_c + h2o_c + gln__L_c --> glu__L_c + amp_c + nad_c + ppi_c + h_c atp_c + prpp_c + nac_c + h2o_c --> pi_c + nicrnt_c + ppi_c + adp_c 2.0 na1_c + 3.0 h_p --> 2.0 na1_p + 3.0 h_c na1_c + 2.0 h_p --> na1_p + 2.0 h_c na1_e <=> na1_p atp_c + gdp_c <=> adp_c + gtp_c atp_c + udp_c <=> utp_c + adp_c cdp_c + atp_c <=> ctp_c + adp_c atp_c + dtdp_c <=> dttp_c + adp_c dgdp_c + atp_c <=> dgtp_c + adp_c atp_c + dudp_c <=> dutp_c + adp_c atp_c + dcdp_c <=> dctp_c + adp_c dadp_c + atp_c <=> datp_c + adp_c nfmalm_c + h2o_c --> h_c + malm_c + for_c h2o_c + Nforglu_c --> glu__L_c + 2.0 h_c + for_c nh4_e <=> nh4_p nh4_p <=> nh4_c ni2_e <=> ni2_p atp_c + ni2_p + h2o_c --> pi_c + ni2_c + h_c + adp_c atp_c + h_c + nicrnt_c <=> ppi_c + dnad_c dmbzid_c + nicrnt_c --> nac_c + h_c + 5prdmbz_c quln_c + prpp_c + 2.0 h_c --> co2_c + nicrnt_c + ppi_c no2_p + h_p <=> h_c + no2_c no2_e <=> no2_p xmp_c + h2o_c --> xtsn_c + pi_c h2o_p + xmp_p --> xtsn_p + pi_p h2o_c + imp_c --> pi_c + ins_c h2o_p + imp_p --> ins_p + pi_p ump_c + h2o_c --> uri_c + pi_c ump_p + h2o_p --> uri_p + pi_p dcmp_c + h2o_c --> pi_c + dcyt_c dcmp_p + h2o_p --> pi_p + dcyt_p cmp_c + h2o_c --> pi_c + cytd_c h2o_p + cmp_p --> cytd_p + pi_p dtmp_c + h2o_c --> thymd_c + pi_c h2o_p + dtmp_p --> pi_p + thymd_p damp_c + h2o_c --> dad_2_c + pi_c damp_p + h2o_p --> dad_2_p + pi_p amp_c + h2o_c --> adn_c + pi_c h2o_p + amp_p --> adn_p + pi_p dgmp_c + h2o_c --> dgsn_c + pi_c h2o_p + dgmp_p --> dgsn_p + pi_p h2o_c + gmp_c --> pi_c + gsn_c h2o_p + gmp_p --> gsn_p + pi_p 5.0 h_c + 3.0 nadh_c + no2_c --> nh4_c + 3.0 nad_c + 2.0 h2o_c o2_e <=> o2_p o2_p <=> o2_c oaa_c + h_c --> co2_c + pyr_c oxoarg__L_c + h_c --> co2_c + gdbtal_c 2obut_c + nad_c + coa_c --> co2_c + ppcoa_c + nadh_c oca_c --> oaa_c + pyr_c orn_c + cbp_c <=> pi_c + h_c + citr__L_c succoa_c + acac_c --> succ_c + aacoa_c octa_e <=> octa_p ohpb_c + glu__L_c <=> akg_c + phthr_c 4mop_c + nad_c + coa_c <=> ivcoa_c + co2_c + nadh_c 3mob_c + nad_c + coa_c --> co2_c + ibcoa_c + nadh_c 3mop_c + nad_c + coa_c --> co2_c + nadh_c + 2mbcoa_c omaenol_c + h2o_c --> oca_c omaketo_c <=> omaenol_c h_c + 3c4mop_c --> co2_c + 4mop_c orot5p_c + h_c --> co2_c + ump_c op4en_c + h2o_c --> 4h2opntn_c 2hchd_c + h2o_c --> 4hoxoh_c h2o_c + chpd_c --> 4h2oxov_c orn_c --> pro__L_c + nh4_c orn_c + h_c --> co2_c + ptrc_c acorn_c + glu__L_c <=> orn_c + acglu_c atp_c + orn_p + h2o_c --> orn_c + pi_c + h_c + adp_c orn_e <=> orn_p ppi_c + orot5p_c <=> orot_c + prpp_c 2oxoadp_c + h_c + lpam_c --> co2_c + S_gtrdhdlp_c 5odhf2a_c + h2o_c --> 3oxoadp_c + h_c oxptn_c + nad_c + h2o_c <=> glutar_c + nadh_c + 2.0 h_c nad_c + 1pyr5c_c + 2.0 h2o_c --> glu__L_c + nadh_c + h_c 1pyr5c_c + nadph_c + 2.0 h_c --> pro__L_c + nadp_c chor_c + nh4_c --> 4adcho_c + h2o_c pac_c + atp_c + coa_c <=> amp_c + phaccoa_c + ppi_c na1_p + pac_p <=> na1_c + pac_c pac_e <=> pac_p atp_c + ala_B_c + pant__R_c --> pnto__R_c + amp_c + ppi_c + h_c udcpp_c + ugmda_c --> uagmda_c + ump_c atp_c + hco3_c + pyr_c --> pi_c + oaa_c + h_c + adp_c pre4_c + amet_c --> pre5_c + h_c + ahcys_c pre3b_c + amet_c --> pre4_c + 3.0 h_c + ahcys_c dscl_c + amet_c --> h_c + pre3a_c + ahcys_c pre6a_c + nadph_c + h_c --> pre6b_c + nadp_c 2.0 amet_c + pre6b_c --> co2_c + 2.0 ahcys_c + 2.0 h_c + pre8_c pre8_c + h_c --> hgbyr_c o2_c + 34dhbz_c --> CCbuttc_c + 2.0 h_c pyr_c + nad_c + coa_c --> co2_c + nadh_c + accoa_c pyr_c + h_c + lpam_c --> co2_c + adhlam_c adhlam_c + coa_c <=> dhlam_c + accoa_c nad_c + dhlam_c <=> nadh_c + h_c + lpam_c o2_c + pdx5p_c --> pydx5p_c + h2o2_c phthr_c + dxyl5p_c + nad_c --> co2_c + pi_c + nadh_c + h_c + 2.0 h2o_c + pdx5p_c h2o_c + pdx5p_c --> pi_c + pydxn_c atp_c + pe120_c + h2o_c --> pe120_p + pi_c + h_c + adp_c atp_c + pe160_c + h2o_c --> pi_c + pe160_p + h_c + adp_c atp_c + pe161_c + h2o_c --> pi_c + pe161_p + h_c + adp_c pe180_c + atp_c + h2o_c --> pi_c + h_c + pe180_p + adp_c atp_c + pe181_c + h2o_c --> pi_c + h_c + adp_c + pe181_p pentso3_e <=> pentso3_p nad_c + 4per_c <=> nadh_c + h_c + ohpb_c gam1p_c <=> gam6p_c nad_c + 3pg_c <=> nadh_c + h_c + 3php_c g6p_c <=> f6p_c 3pg_c + atp_c <=> 13dpg_c + adp_c 6pgl_c + h2o_c --> h_c + 6pgc_c nadph_c + 6p2dhglcn_c <=> nadp_c + 2.0 h_c + 6pgc_c 2pg_c <=> 3pg_c g1p_c <=> g6p_c atp_c + pgp120_c + h2o_c --> pi_c + h_c + pgp120_p + adp_c pgp160_c + atp_c + h2o_c --> pi_c + pgp160_p + h_c + adp_c atp_c + pgp161_c + h2o_c --> pi_c + pgp161_p + h_c + adp_c atp_c + h2o_c + pgp180_c --> pi_c + pgp180_p + h_c + adp_c atp_c + pgp181_c + h2o_c --> pi_c + pgp181_p + h_c + adp_c pgp120_c + h2o_c --> pi_c + pg120_c h2o_p + pgp120_p --> pg120_p + pi_p pgp160_c + h2o_c --> pi_c + pg160_c h2o_p + pgp160_p --> pg160_p + pi_p pgp161_c + h2o_c --> pi_c + pg161_c pgp161_p + h2o_p --> pg161_p + pi_p h2o_c + pgp180_c --> pi_c + pg180_c pgp180_p + h2o_p --> pg180_p + pi_p pgp181_c + h2o_c --> pi_c + pg181_c h2o_p + pgp181_p --> pg181_p + pi_p cdpdddecg_c + glyc3p_c --> pgp120_c + cmp_c + h_c glyc3p_c + cdpdhdecg_c --> pgp160_c + cmp_c + h_c glyc3p_c + cdpdhdec9eg_c --> cmp_c + pgp161_c + h_c cdpdodecg_c + glyc3p_c --> cmp_c + h_c + pgp180_c glyc3p_c + cdpdodec11eg_c --> pgp181_c + cmp_c + h_c C120mclPHA_c + C80mclPHA_c + C100mclPHA_c + C60mclPHA_c <=> mclPHA_c phaccoa_c + o2_c + h2_c --> 2dhphaccoa_c R_3hdcoa_c + mclPHAg_c --> C100mclPHA_c + coa_c R_3hddcoa_c + mclPHAg_c --> C120mclPHA_c + coa_c R_3hcddec5ecoa_c + mclPHAg_c --> C121mclPHA_c + coa_c R_3hmrscoa_c + mclPHAg_c --> C140mclPHA_c + coa_c R_3hcmrs7ecoa_c + mclPHAg_c --> C141mclPHA_c + coa_c R_3hhcoa_c + mclPHAg_c --> C60mclPHA_c + coa_c R_3hocoa_c + mclPHAg_c --> C80mclPHA_c + coa_c akg_c + phe__L_c <=> phpyr_c + glu__L_c thbpt_c + o2_c + phe__L_c --> tyr__L_c + dhbpt_c + h2o_c atp_c + trnaphe_c + phe__L_c --> phetrna_c + ppi_c + amp_c h_p + phe__L_p <=> phe__L_c + h_c phe__L_e <=> phe__L_p h_p + pi_p <=> pi_c + h_c pi_e <=> pi_p atp_c + pi_p + h2o_c --> 2.0 pi_c + h_c + adp_c 5aprbu_c + h2o_c --> pi_c + 4r5au_c 4ampm_c + atp_c --> adp_c + 2mahmp_c atp_c + pnto__R_c --> h_c + 4ppan_c + adp_c ppi_c + h2o_c --> 2.0 pi_c + h_c 2.0 5aop_c --> ppbng_c + h_c + 2.0 h2o_c co2_c + pep_c + h2o_c --> pi_c + oaa_c + h_c 4ppcys_c + h_c --> co2_c + pan4p_c ppgpp_c + h2o_c --> ppi_c + gdp_c ppi_c + atp_c <=> pppi_c + adp_c r1p_c <=> r5p_c cys__L_c + ctp_c + 4ppan_c --> pi_c + cdp_c + 4ppcys_c + h_c nad_c + pphn_c --> co2_c + 34hpp_c + nadh_c pphn_c + h_c --> co2_c + h2o_c + phpyr_c 1.5 o2_c + pppg9_c --> ppp9_c + 3.0 h2o_c nad_c + pprdn_c + 2.0 h2o_c --> 5aptn_c + nadh_c + h_c pyr_c + atp_c + h2o_c --> amp_c + pep_c + 2.0 h_c + pi_c uaagmda_c --> udcpdp_c + peptido_kt_c + h_c atp_c + gly_c + pram_c --> pi_c + h_c + gar_c + adp_c pran_c <=> 2cpr5p_c atp_c + fpram_c --> pi_c + air_c + 2.0 h_c + adp_c h2o_c + prbamp_c --> prfp_c asp__L_c + atp_c + 5aizc_c <=> pi_c + h_c + 25aics_c + adp_c prbatp_c + h2o_c --> ppi_c + h_c + prbamp_c gln__L_c + atp_c + h2o_c + fgam_c --> pi_c + adp_c + glu__L_c + fpram_c + h_c prfp_c --> prlp_c pro__L_c + fad_c --> 1pyr5c_c + h_c + fadh2_c pro__L_c + atp_c + trnapro_c --> amp_c + protrna_c + ppi_c atp_c + pro__L_p + h2o_c --> pi_c + pro__L_c + h_c + adp_c pro__L_p + h_p --> pro__L_c + h_c na1_p + pro__L_p --> na1_c + pro__L_c pro__L_e <=> pro__L_p r5p_c + atp_c <=> amp_c + prpp_c + h_c pep_c + skm5p_c <=> pi_c + 3psme_c ps120_c + h_c --> co2_c + pe120_c h_c + ps160_c --> co2_c + pe160_c h_c + ps161_c --> co2_c + pe161_c h_c + ps180_c --> co2_c + pe180_c ps181_c + h_c --> co2_c + pe181_c glu__L_c + 3php_c <=> akg_c + pser__L_c pser__L_c + h2o_c --> ser__L_c + pi_c ser__L_c + cdpdddecg_c --> cmp_c + h_c + ps120_c ser__L_c + cdpdhdecg_c --> cmp_c + h_c + ps160_c ser__L_c + cdpdhdec9eg_c --> cmp_c + h_c + ps161_c ser__L_c + cdpdodecg_c --> cmp_c + h_c + ps180_c ser__L_c + cdpdodec11eg_c --> ps181_c + cmp_c + h_c accoa_c + pi_c <=> actp_c + coa_c p_tol_c + o2_c + nadh_c + h_c --> dh4mchc_c + nad_c atp_c + h_c + pan4p_c <=> ppi_c + dpcoa_c atp_c + ptrc_p + h2o_c --> pi_c + ptrc_c + h_c + adp_c ptrc_e <=> ptrc_p p_xyl_c + o2_c + nadh_c + h_c --> 4mbzalc_c + nad_c + h2o_c h2o_c + pydx5p_c --> pi_c + pydx_c pep_c + h_c + adp_c --> pyr_c + atp_c uri_c + pi_c <=> r1p_c + ura_c o2_c + dhpyr_c --> nfmalm_c + h_c p_xyl_p <=> p_xyl_c p_xyl_e <=> p_xyl_p pqq_c + quin_kt_c --> pqqh2_c + 3dhq_c quin_kt_e <=> quin_kt_p quin_kt_p + h_p <=> h_c + quin_kt_c iasp_c + dhap_c --> pi_c + 2.0 h2o_c + quln_c 0.5 o2_c + h_c + pre3a_c --> pre3b_c amet_c + pre5_c + h2o_c --> ahcys_c + ac_c + pre6a_c + h_c hgbyr_c + 2.0 gln__L_c + 2.0 atp_c + h2o_c --> hgbam_c + 2.0 glu__L_c + ppi_c + h_c + 2.0 adp_c atp_c + r15bp_c --> prpp_c + adp_c atp_c + r1p_c --> r15bp_c + adp_c + h_c ribflv_c + atp_c --> fmn_c + h_c + adp_c db4p_c + 4r5au_c --> dmlz_c + pi_c + 2.0 h2o_c 2.0 dmlz_c --> 4r5au_c + ribflv_c rib__D_c + atp_c <=> r5p_c + h_c + adp_c 3odcoa_c + nadph_c + h_c <=> R_3hdcoa_c + nadp_c nadph_c + h_c + 3oddcoa_c <=> R_3hddcoa_c + nadp_c nadph_c + h_c + 3otdcoa_c <=> nadp_c + R_3hmrscoa_c 3ohcoa_c + nadph_c + h_c <=> nadp_c + R_3hhcoa_c nadph_c + h_c + 3oocoa_c <=> R_3hocoa_c + nadp_c atp_c + rib__D_p + h2o_c --> pi_c + rib__D_c + h_c + adp_c rib__D_e <=> rib__D_p nadh_c + rbrdxOX_c <=> nad_c + rbrdxRD_c + h_c adp_c + trdrd_c --> dadp_c + trdox_c + h2o_c trdrd_c + gdp_c --> trdox_c + dgdp_c + h2o_c trdrd_c + cdp_c --> trdox_c + dcdp_c + h2o_c trdrd_c + udp_c --> trdox_c + h2o_c + dudp_c ru5p__D_c <=> xu5p__D_c r5p_c <=> ru5p__D_c h2o_c + 5prdmbz_c --> rdmbzi_c + pi_c sucarg_c + 2.0 h_c + 2.0 h2o_c --> co2_c + 2.0 nh4_c + sucorn_c so4_c + h_c + atp_c --> ppi_c + aps_c sarcs_c + o2_c + h2o_c --> h2o2_c + gly_c + fald_c 2.0 gthrd_c + scys__L_c <=> cys__L_c + gthox_c + h_c + so3_c h2o_c + sl26da_c --> succ_c + 26dap_LL_c akg_c + sl26da_c <=> sl2a6o_c + glu__L_c atp_c + selmeth_c + h2o_c --> pi_c + seasmet_c + ppi_c ser__L_c + accoa_c <=> acser_c + coa_c ser__L_c <=> pyr_c + nh4_c atp_c + ser__L_c + trnaser_c --> amp_c + ppi_c + sertrna_c ser__L_c <=> pyr_c + h_c + nh3_c ser__L_p + h_p <=> ser__L_c + h_c ser__L_e <=> ser__L_p h2o_c + sucglu_c --> succ_c + glu__L_c nad_c + sucgsa_c + h2o_c --> sucglu_c + nadh_c + 2.0 h_c dscl_c + nad_c --> scl_c + nadh_c + h_c fe2_c + scl_c --> 3.0 h_c + sheme_c 3dhsk_c + nadph_c + h_c <=> skm_c + nadp_c skm_c + atp_c --> h_c + adp_c + skm5p_c cys__L_c + suchms_c --> cyst__L_c + succ_c + h_c h2s_c + suchms_c <=> hcys__L_c + h_c + succ_c suchms_c + h2o_c <=> 2obut_c + nh4_c + succ_c + h_c so4_e + 2.0 na1_e <=> 2.0 na1_c + so4_c so4_e <=> so4_p akg_c + sucorn_c --> sucgsa_c + glu__L_c atp_c + spmd_p + h2o_c --> pi_c + spmd_c + h_c + adp_c spmd_e <=> spmd_p ptrc_c + ametam_c --> 5mta_c + spmd_c + h_c nadp_c + sucsal_c + h2o_c <=> nadph_c + succ_c + 2.0 h_c succ_p + 2.0 h_p --> succ_c + 2.0 h_c succ_e <=> succ_p succ_c + fad_c <=> fum_c + fadh2_c q8_c + succ_c --> fum_c + q8h2_c atp_c + succ_c + coa_c <=> pi_c + succoa_c + adp_c 3.0 nadph_c + 5.0 h_c + so3_c --> 3.0 nadp_c + h2s_c + 3.0 h2o_c atp_c + so4_p + h2o_c --> pi_c + h_c + adp_c + so4_c tdec2eACP_c <=> cdec3eACP_c T4hcinnm_e <=> T4hcinnm_p T4hcinnm_p <=> T4hcinnm_c g3p_c + s7p_c <=> e4p_c + f6p_c akg_c + taur_c + o2_c --> co2_c + aacald_c + succ_c + h_c + so3_c taur_p + atp_c + h2o_c --> pi_c + taur_c + h_c + adp_c taur_e <=> taur_p nadph_c + nad_c <=> nadp_c + nadh_c h2o_c + thdp_c + succoa_c --> sl2a6o_c + coa_c athr__L_c <=> gly_c + acald_c thr__L_c <=> gly_c + acald_c thr__L_c --> 2obut_c + nh4_c phom_c + h2o_c --> pi_c + thr__L_c atp_c + thr__L_c + trnathr_c --> amp_c + ppi_c + thrtrna_c thr__L_p + atp_c + h2o_c --> pi_c + thr__L_c + h_c + adp_c thr__L_e <=> thr__L_p r5p_c + xu5p__D_c <=> g3p_c + s7p_c xu5p__D_c + e4p_c <=> g3p_c + f6p_c dump_c + mlthf_c --> dtmp_c + dhf_c tol_e <=> tol_p tol_p <=> tol_c dhap_c <=> g3p_c trdox_c + nadph_c + h_c --> nadp_c + trdrd_c ser__L_c + 3ig3p_c <=> g3p_c + trp__L_c + h2o_c ser__L_c + indole_c --> trp__L_c + h2o_c 3ig3p_c <=> indole_c + g3p_c 2h3oppan_c + nadh_c + h_c <=> glyc__R_c + nad_c atp_c + h2o_c + tsul_p --> tsul_c + pi_c + h_c + adp_c tsul_e <=> tsul_p ttdca_e <=> ttdca_p tyr__L_c + akg_c <=> 34hpp_c + glu__L_c tyr__L_c + atp_c + trnatyr_c --> tyrtrna_c + amp_c + ppi_c h_p + tyr__L_p <=> tyr__L_c + h_c tyr__L_e <=> tyr__L_p atp_c + 26dap__M_c + uamag_c --> ugmd_c + pi_c + h_c + adp_c pep_c + uacgam_c --> pi_c + uaccg_c acgam1p_c + utp_c + h_c --> uacgam_c + ppi_c uagmda_c + uacgam_c --> udp_c + h_c + uaagmda_c atp_c + glu__D_c + uama_c --> pi_c + h_c + uamag_c + adp_c atp_c + uamr_c + ala__L_c --> pi_c + uama_c + h_c + adp_c nadph_c + h_c + uaccg_c --> nadp_c + uamr_c udcpdp_c + h2o_c --> udcpp_c + pi_c + h_c ugmd_c + atp_c + alaala_c --> pi_c + h_c + ugmda_c + adp_c 4hbz_p + h_p <=> 4hbz_c + h_c atp_c + ump_c <=> udp_c + adp_c glu__L_c + 2kmb_c --> akg_c + met__L_c uppg3_c + 2.0 amet_c --> dscl_c + 2.0 ahcys_c + h_c hmbil_c --> uppg3_c + h2o_c 4.0 h_c + uppg3_c --> 4.0 co2_c + cpppg3_c 4.0 h_c + uppg1_c --> 4.0 co2_c + cpppg1_c cala_c + 2.0 h_c + h2o_c --> co2_c + nh4_c + ala_B_c prpp_c + ura_c --> ppi_c + ump_c urcan_c + h2o_c --> 4izp_c urea_c + 2.0 h_c + h2o_c --> co2_c + 2.0 nh4_c akg_c + val__L_c <=> 3mob_c + glu__L_c trnaval_c + atp_c + val__L_c --> valtrna_c + amp_c + ppi_c atp_c + val__L_p + h2o_c --> pi_c + val__L_c + h_c + adp_c val__L_e <=> val__L_p h_p + vanlt_p <=> h_c + vanlt_c vanln_e <=> vanln_p vanlt_e <=> vanlt_p vanln_c + nad_c + h2o_c --> vanlt_c + nadh_c + 2.0 h_c 4hbald_c + nad_c + h2o_c --> 4hbz_c + nadh_c + 2.0 h_c nad_c + h2o_c + 34dhbald_c --> 34dhbz_c + nadh_c + 2.0 h_c vanln_p + h_p <=> h_c + vanln_c o2_c + vanlt_c + nadh_c + h_c --> fald_c + nad_c + 34dhbz_c + h2o_c nad_c + h2o_c + xan_c --> urate_c + nadh_c + h_c tol_c + o2_c + nadh_c + h_c --> nad_c + h2o_c + bzalc_c xtsn_c + h2o_c --> rib__D_c + xan_c pentso3_p + atp_c + h2o_c --> pi_c + pentso3_c + h_c + adp_c 5mthglu_c <=> dna5mtc_c <=> dna_c <=> mclPHAg_c <=> pqq_c <=> pqqh2_c <=> thglu_c <=>

models.minho.iMM904

Name	iMM904
Number of metabolites	1228
Number of reactions	1577
Reactions	h2o_c + 13BDglcn_c --> glc_D_c h2o_e + 13BDglcn_e --> glc_D_e udpg_c --> h_c + 13BDglcn_c + udp_c udpg_c --> h_c + udp_c + 16BDglcn_c h_c + h2o_c + 23camp_c --> amp2p_c 2dda7p_c <=> 2dda7p_m 2dhp_c <=> 2dhp_m h2o_c + 2doxg6p_c --> 2dglc_c + pi_c 2hb_c + nad_c <=> h_c + 2obut_c + nadh_c h_e + 2hb_e <=> h_c + 2hb_c 2hpmhmbq_m + amet_m --> q6_m + h_m + ahcys_m o2_m + 2hp6mp_m --> h2o_m + 2hp6mbq_m 2hp6mbq_m + amet_m --> h_m + 2hpmmbq_m + ahcys_m 0.5 o2_m + 2hpmmbq_m --> 2hpmhmbq_m 2mbac_c --> 2mbac_e 2mbald_c <=> 2mbald_e 2mbald_c <=> 2mbald_m 2mbtoh_c <=> 2mbtoh_e 2mbtoh_c <=> 2mbtoh_m 2mppal_c <=> 2mppal_e 2mppal_c <=> 2mppal_m 2obut_c <=> 2obut_m 2oxoadp_m --> 2oxoadp_c 2phetoh_e <=> 2phetoh_c 2phetoh_m <=> 2phetoh_c nadh_m + h_m + 34hpp_m --> nad_m + 34hpl_m 34hpp_c + o2_c --> co2_c + hgentis_c h_c + 34hpp_c <=> h_m + 34hpp_m h_c + 34hpp_c <=> h_x + 34hpp_x 3c3hmp_c <=> 3c3hmp_e 3c3hmp_c <=> 3c3hmp_m 3c4mop_c <=> 3c4mop_m 3dh5hpb_m + amet_m --> h_m + 3hph5mb_m + ahcys_m 3dh5hpb_c <=> 3dh5hpb_m h_c + 3dsphgn_c + nadph_c --> sphgn_c + nadp_c 3hanthrn_c + o2_c --> h_c + cmusa_c 3hph5mb_m --> co2_m + 2hp6mp_m 3c2hmp_c + amet_c --> 3ipmmest_c + ahcys_c 3mbald_c <=> 3mbald_e 3mbald_c <=> 3mbald_m h_c + 3mob_c --> co2_c + 2mppal_c 3mob_c <=> 3mob_m h_c + 3mop_c --> co2_c + 2mbald_c 3mop_e <=> 3mop_c 3mop_c <=> 3mop_m 3ophb_5_c + 0.5 o2_c --> 3dh5hpb_c 3ophb_5_c <=> 3ophb_5_m 4abutn_c <=> 4abutn_m 4abut_c <=> 4abut_m 4abz_c <=> 4abz_e 4abz_c <=> 4abz_m 4h2oglt_c <=> 4h2oglt_m 4h2oglt_c <=> 4h2oglt_x nad_m + coucoa_m + h2o_m + coa_m --> nadh_m + 4hbzcoa_m + accoa_m + h_m h2o_m + 4hbzcoa_m --> h_m + 4hbz_m + coa_m 4hbz_c <=> 4hbz_m nad_m + h2o_m + 4hglusa_m <=> nadh_m + e4hglu_m + 2.0 h_m 4hpro_LT_c <=> 4hpro_LT_m h2o_c + phthr_c --> 4hthr_c + pi_c 4mop_c + h_c --> co2_c + 3mbald_c 5aop_e + h_e --> h_c + 5aop_c 5aop_c <=> 5aop_m 6pgl_c <=> 6pgl_r 8aonn_e + h_e <=> h_c + 8aonn_c h2o_c + 4aabutn_c --> ac_c + 4abut_c h2o_c + aact_c + o2_c --> h2o2_c + nh4_c + mthgxl_c h_c + nadph_c + L2aadp_c + atp_c --> L2aadp6sa_c + amp_c + ppi_c + nadp_c h_c + L2aadp_c + atp_c + nadh_c --> L2aadp6sa_c + amp_c + ppi_c + nad_c 2oxoadp_c + glu_L_c <=> akg_c + L2aadp_c akg_c + 4abut_c --> sucsal_c + glu_L_c abt_e <=> abt_c nad_m + h2o_m + 4abutn_m --> nadh_m + 4abut_m + 2.0 h_m h_e + 4abut_e <=> h_c + 4abut_c 2.0 accoa_c --> coa_c + aacoa_c 2.0 accoa_m --> coa_m + aacoa_m 3odcoa_x + coa_x --> occoa_x + accoa_x coa_x + 3oddcoa_x --> accoa_x + dcacoa_x coa_x + 3otdcoa_x --> accoa_x + ddcacoa_x coa_x + 3ohdcoa_x --> tdcoa_x + accoa_x coa_x + 3ohodcoa_x --> pmtcoa_x + accoa_x coa_x + 3ohxccoa_x --> accoa_x + ttccoa_x 2.0 acald_c --> actn_R_c acald_e <=> acald_c acald_m <=> acald_c atp_c + accoa_c + hco3_c <=> adp_c + pi_c + h_c + malcoa_c accoa_m + atp_m + hco3_m <=> pi_m + malcoa_m + adp_m + h_m accoa_c <=> accoa_n aces_c --> aces_e accoa_c + gam6p_c <=> h_c + coa_c + acgam6p_c acgam6p_c <=> acgam1p_c atp_m + acglu_m --> adp_m + acg5p_m accoa_m + glu_L_m --> h_m + coa_m + acglu_m pyr_m + h_m + 2obut_m --> 2ahbut_m + co2_m iamac_c + h2o_c --> ac_c + h_c + iamoh_c ibutac_c + h2o_c --> ac_c + ibutoh_c + h_c aces_c + h2o_c --> ac_c + h_c + etoh_c 2.0 pyr_m + h_m --> co2_m + alac_S_m accoa_m + h2o_m --> h_m + coa_m + ac_m o2_x + dcacoa_x --> dc2coa_x + h2o2_x ddcacoa_x + o2_x --> h2o2_x + dd2coa_x tdcoa_x + o2_x --> td2coa_x + h2o2_x o2_x + pmtcoa_x --> hdd2coa_x + h2o2_x o2_x + stcoa_x --> od2coa_x + h2o2_x hexccoa_x + o2_x --> hxc2coa_x + h2o2_x accoa_c + ACP_c <=> coa_c + acACP_c ACP_m + accoa_m <=> acACP_m + coa_m acon_T_c + amet_c --> acon5m_c + ahcys_c cit_c <=> icit_c 2mcit_m <=> micit_m cit_m <=> icit_m glu_L_m + acg5sa_m --> acorn_m + akg_m h2o_e + fmn_e --> pi_e + ribflv_e h2o_m + coa_m --> pan4p_m + 2.0 h_m + pap_m acrn_c --> acrn_m acrn_x --> acrn_c atp_c + ac_c + coa_c --> accoa_c + amp_c + ppi_c atp_m + coa_m + ac_m --> amp_m + accoa_m + ppi_m ac_x + atp_x + coa_x --> ppi_x + amp_x + accoa_x h_e + ac_e <=> h_c + ac_c ac_c <=> ac_m ac_c <=> ac_x ac_e <=> ac_c h_c + h2o_c + adn_c --> ins_c + nh4_c 4adcho_c --> h_c + 4abz_c + pyr_c chor_c + gln_L_c --> glu_L_c + 4adcho_c h_c + h2o_c + ade_c --> hxan_c + nh4_c ade_e + h_e --> h_c + ade_c ade_c <=> ade_m h_c + nadph_c + 0.01 1agly3p_SC_c --> 0.01 1ag3p_SC_c + nadp_c amp_c + atp_c <=> 2.0 adp_c amp_m + atp_m <=> 2.0 adp_m amp_c + gtp_c <=> gdp_c + adp_c amp_m + gtp_m <=> adp_m + gdp_m amp_c + itp_c <=> adp_c + idp_c amp_m + itp_m <=> adp_m + idp_m h_c + amet_c --> ametam_c + co2_c atp_c --> ppi_c + camp_c atp_c + adn_c --> amp_c + h_c + adp_c adn_c + h2o_c --> rib_D_c + ade_c h_e + adn_e --> h_c + adn_c prpp_c + ade_c --> amp_c + ppi_c atp_c + aps_c --> h_c + adp_c + paps_c dcamp_c <=> amp_c + fum_c 25aics_c <=> aicar_c + fum_c gtp_c + imp_c + asp_L_c --> dcamp_c + pi_c + 2.0 h_c + gdp_c 0.17 hdcoa_c + 0.27 pmtcoa_c + 0.06 ddcacoa_c + 0.24 odecoa_c + 0.05 stcoa_c + 0.02 dcacoa_c + 0.01 1ag3p_SC_c + 0.09 ocdycacoa_c + 0.1 tdcoa_c --> 0.01 pa_SC_c + coa_c h_m + nadph_m + acg5p_m --> pi_m + nadp_m + acg5sa_m ala_L_c + glx_c --> gly_c + pyr_c ahcys_c <=> ahcys_m h2o_c + ahcys_c --> adn_c + hcys_L_c 2.0 h_c + air_c --> gcald_c + pi_c + 4ahmmp_c achms_c + ch4s_c --> h_c + ac_c + met_L_c achms_c + h2s_c --> h_c + ac_c + hcys_L_c 10fthf_c + aicar_c <=> fprica_c + thf_c co2_c + air_c <=> h_c + 5aizc_c lpam_m + h_m + akg_m <=> sdhlam_m + co2_m sdhlam_m + coa_m --> dhlam_m + succoa_m akg_c + mal_L_e <=> akg_e + mal_L_c h_c + akg_c <=> akg_n + h_n h_e + akg_e <=> h_c + akg_c akg_c <=> akg_x ahdt_c + 3.0 h2o_c --> dhnpt_c + 2.0 h_c + 3.0 pi_c gly_m + h_m + succoa_m --> co2_m + coa_m + 5aop_m akg_c + ala_L_c <=> pyr_c + glu_L_c ala_L_m + akg_m <=> pyr_m + glu_L_m atp_c + ala_L_c + trnaala_c --> alatrna_c + amp_c + ppi_c ala_L_e + h_e <=> h_c + ala_L_c ala_L_m --> ala_L_c h_c + nadph_c + glyald_c --> nadp_c + glyc_c h_c + 2mbald_c + nadh_c --> nad_c + 2mbtoh_c 2mbald_m + h_m + nadh_m --> nad_m + 2mbtoh_m h_c + nadph_c + 2mbald_c --> nadp_c + 2mbtoh_c h_c + 2mppal_c + nadh_c --> ibutoh_c + nad_c nadh_m + 2mppal_m + h_m --> nad_m + ibutoh_m h_c + nadph_c + 2mppal_c --> ibutoh_c + nadp_c h_c + 3mbald_c + nadh_c --> iamoh_c + nad_c nadh_m + 3mbald_m + h_m --> iamoh_m + nad_m h_c + nadph_c + 3mbald_c --> iamoh_c + nadp_c h_c + pacald_c + nadh_c --> 2phetoh_c + nad_c nadh_m + h_m + pacald_m --> nad_m + 2phetoh_m h_c + nadph_c + pacald_c --> 2phetoh_c + nadp_c h_c + nadh_c + id3acald_c --> ind3eth_c + nad_c id3acald_m + nadh_m + h_m --> ind3eth_m + nad_m nad_c + etoh_c --> h_c + acald_c + nadh_c h_c + acald_c + nadh_c --> nad_c + etoh_c acald_m + nadh_m + h_m --> nad_m + etoh_m nad_c + etoh_c <=> h_c + acald_c + nadh_c h2o_c + pacald_c + nad_c --> 2.0 h_c + pac_c + nadh_c nad_m + id3acald_m + h2o_m --> nadh_m + ind3ac_m + 2.0 h_m h2o_c + id3acald_c + nadp_c --> nadph_c + 2.0 h_c + ind3ac_c nadp_m + id3acald_m + h2o_m --> 2.0 h_m + nadph_m + ind3ac_m h2o_c + aproa_c + nad_c --> ala_B_c + 2.0 h_c + nadh_c acald_m + nad_m + h2o_m --> nadh_m + 2.0 h_m + ac_m h2o_c + acald_c + nadp_c --> nadph_c + 2.0 h_c + ac_c acald_m + nadp_m + h2o_m --> 2.0 h_m + nadph_m + ac_m alltt_c + h2o_c <=> urea_c + urdglyc_c alltn_c + h2o_c <=> h_c + alltt_c alltn_e --> alltn_c alltt_e --> alltt_c 3.0 h_c + allphn_c + h2o_c --> 2.0 co2_c + 2.0 nh4_c 8aonn_c + amet_c <=> dann_c + amob_c amet_e + h_e --> h_c + amet_c amet_c <=> amet_m h2o_c + 4gudbd_c --> 4gudbutn_c + nh4_c h2o_c + pad_c --> pac_c + nh4_c iad_c + h2o_c --> ind3ac_c + nh4_c amp_c + h_c + h2o_c --> nh4_c + imp_c amp_c + h2o_c --> ade_c + r5p_c amp_n <=> amp_c prpp_c + anth_c --> ppi_c + pran_c chor_c + gln_L_c --> anth_c + h_c + pyr_c + glu_L_c h_c + 2aobut_c --> co2_c + aact_c h2o_c + ap4a_c <=> 2.0 h_c + 2.0 adp_c h2o_c + aprut_c + o2_c --> h2o2_c + nh4_c + n4abutn_c Dara14lac_c + o2_c <=> ertascb_D_c + h2o2_c arab_D_c + nadp_c --> h_c + Dara14lac_c + nadph_c h_c + arab_L_c + nadph_c --> nadp_c + abt_c arab_D_e <=> arab_D_c arab_L_e <=> arab_L_c arg_L_c + h2o_c --> orn_c + urea_c argsuc_c <=> arg_L_c + fum_c atp_c + citr_L_c + asp_L_c <=> h_c + amp_c + ppi_c + argsuc_c atp_c + trnaarg_c + arg_L_c --> argtrna_c + amp_c + ppi_c trnaarg_m + arg_L_m + atp_m --> amp_m + argtrna_m + ppi_m arg_L_c + h_c <=> h_m + arg_L_m arg_L_e + h_e <=> h_c + arg_L_c arg_L_c + h_v --> h_c + arg_L_v his_L_c + amet_c --> h_c + NPmehis_c + ahcys_c nadph_c + 4pasp_c + h_c --> pi_c + aspsa_c + nadp_c asn_L_c + h2o_c --> asp_L_c + nh4_c h2o_e + asn_L_e --> nh4_e + asp_L_e atp_c + h2o_c + gln_L_c + asp_L_c --> h_c + asn_L_c + amp_c + ppi_c + glu_L_c atp_c + asn_L_c + trnaasn_c --> asntrna_c + amp_c + ppi_c atp_m + trnaasn_m + asn_L_m --> asntrna_m + amp_m + ppi_m h_c + asn_L_c <=> h_m + asn_L_m h_e + asn_L_e <=> h_c + asn_L_c asn_L_c + h_v --> h_c + asn_L_v asn_L_v + h_v --> h_c + asn_L_c cbp_c + asp_L_c --> cbasp_c + pi_c + h_c asp_L_m + glu_L_c --> glu_L_m + asp_L_c asp_L_c + glu_L_x <=> glu_L_c + asp_L_x atp_c + asp_L_c --> adp_c + 4pasp_c fad_m + asp_L_c --> h_c + fadh2_m + iasp_c akg_c + asp_L_c <=> glu_L_c + oaa_c asp_L_m + akg_m <=> glu_L_m + oaa_m akg_x + asp_L_x <=> oaa_x + glu_L_x atp_c + trnaasp_c + asp_L_c --> asptrna_c + amp_c + ppi_c asp_L_m + trnaasp_m + atp_m --> asptrna_m + amp_m + ppi_m h_c + asp_L_c <=> h_m + asp_L_m h_c + asp_L_c <=> asp_L_n + h_n asp_L_e + h_e <=> h_c + asp_L_c asp_L_n <=> asp_L_c asp_L_v + h_v --> h_c + asp_L_c athr_L_c + nadp_c <=> h_c + nadph_c + 2aobut_c atp_c + amp_x + h_x --> h_c + amp_c + atp_x h_c + atp_c + adp_c --> ap4a_c + pi_c h_c + gtp_c + adp_c --> ap4g_c + pi_c h_c + gtp_c + gdp_c --> pi_c + gp4g_c atp_c + 2.0 h2o_c --> amp_c + 2.0 h_c + 2.0 pi_c atp_c + h2o_c --> h_c + adp_c + pi_c atp_c + prpp_c --> ppi_c + prbatp_c atp_c + h2o_c --> adp_c + h_e + pi_c 3.0 h_c + adp_g + pi_g --> atp_g + h2o_g + 2.0 h_g pi_m + 3.0 h_c + adp_m --> 2.0 h_m + atp_m + h2o_m adp_v + 3.0 h_c + pi_v --> h2o_v + 2.0 h_v + atp_v atp_m + h_c + adp_c --> atp_c + h_m + adp_m h_x + atp_c + adp_x --> atp_x + h_c + adp_c h_c + atp_c + btn_c --> ppi_c + btamp_c h2o_c + pap_c --> amp_c + pi_c btd_RR_c + nad_c <=> h_c + actn_R_c + nadh_c btd_RR_c <=> btd_RR_e h_e + btn_e --> h_c + btn_c s_c + dtbt_c <=> 2.0 h_c + btn_c h_c + nadph_c + 44mctr_c --> 44mzym_c + nadp_c nadph_c + ergtrol_c + h_c + o2_c --> 2.0 h2o_c + nadp_c + ergtetrol_c ergtrol_c + h_c + o2_c + nadh_c --> 2.0 h2o_c + ergtetrol_c + nad_c nadph_r + ergtetrol_r + h_r --> nadp_r + ergst_r nad_c + 4mzym_int1_c --> co2_c + 4mzym_int2_c + h_c + nadh_c zym_int1_c + nad_c --> co2_c + zym_int2_c + h_c + nadh_c h_c + 4mzym_int2_c + nadph_c --> 4mzym_c + nadp_c h_c + nadph_c + zym_int2_c --> zymst_c + nadp_c 3.0 nadph_c + 3.0 h_c + 44mzym_c + 3.0 o2_c --> 4.0 h2o_c + 4mzym_int1_c + 3.0 nadp_c 3.0 nadph_c + 3.0 h_c + 4mzym_c + 3.0 o2_c --> 4.0 h2o_c + zym_int1_c + 3.0 nadp_c nadph_c + epist_c + h_c + o2_c --> 2.0 h2o_c + ergtrol_c + nadp_c fecost_c --> epist_c 2.0 h2o2_c --> 2.0 h2o_c + o2_c 2.0 h2o2_x --> 2.0 h2o_x + o2_x cbasp_n <=> cbasp_c 2.0 atp_c + h2o_c + hco3_c + gln_L_c --> 2.0 adp_c + cbp_c + pi_c + 2.0 h_c + glu_L_c cbp_c <=> cbp_n h2o2_m + 2.0 focytc_m --> 2.0 ficytc_m + 2.0 h2o_m glyc3p_m + 0.01 cdpdag_SC_m <=> cmp_m + h_m + 0.01 pgp_SC_m cdp_c <=> cdp_n cer1_24_c <=> cer1_24_r cer1_26_c <=> cer1_26_r cer2_24_c <=> cer2_24_r cer2_26_c <=> cer2_26_r cer1_24_r + h_r + coa_r --> ttccoa_r + sphgn_r coa_r + cer1_26_r + h_r --> hexccoa_r + sphgn_r h_r + coa_r + cer2_24_r --> ttccoa_r + psphings_r h_r + coa_r + cer2_26_r --> hexccoa_r + psphings_r nadph_c + cer1_24_c + h_c + o2_c --> h2o_c + cer2_24_c + nadp_c nadph_c + h_c + cer1_26_c + o2_c --> h2o_c + cer2_26_c + nadp_c sphgn_c + ttccoa_c --> h_c + coa_c + cer1_24_c ttccoa_r + sphgn_r --> cer1_24_r + h_r + coa_r hexccoa_c + sphgn_c --> h_c + coa_c + cer1_26_c hexccoa_r + sphgn_r --> coa_r + cer1_26_r + h_r psphings_c + ttccoa_c --> h_c + coa_c + cer2_24_c ttccoa_r + psphings_r --> h_r + coa_r + cer2_24_r psphings_c + hexccoa_c --> h_c + coa_c + cer2_26_c hexccoa_r + psphings_r --> h_r + coa_r + cer2_26_r nadph_c + h_c + cer1_24_c + o2_c --> h2o_c + cer2__24_c + nadp_c nadph_c + h_c + cer1_26_c + o2_c --> h2o_c + cer2__26_c + nadp_c cer2_24_c + h_c + nadph_c + o2_c --> h2o_c + cer3_24_c + nadp_c nadph_c + h_c + cer2_26_c + o2_c --> h2o_c + nadp_c + cer3_26_c h_c + ctp_c + cholp_c --> ppi_c + cdpchol_c zymst_c + o2_c + amet_c --> 2.0 h2o_c + ahcys_c + h_c + ergtetrol_c h_e + chol_e --> h_c + chol_c atp_c + chol_c --> h_c + adp_c + cholp_c chor_c --> pphn_c 3psme_c --> chor_c + pi_c chor_c --> 4hbz_c + pyr_c chitin_c + h2o_c --> ac_c + h_c + chitos_c udpacgal_c --> h_c + chitin_c + udp_c cit_e + h_e <=> h_c + cit_c mal_L_m + cit_c <=> cit_m + mal_L_c cit_x + mal_L_c <=> mal_L_x + cit_c cit_c + pep_m <=> pep_c + cit_m icit_m + cit_c <=> icit_c + cit_m cit_c + icit_x <=> cit_x + icit_c 0.01 pg_SC_m + 0.01 cdpdag_SC_m --> 0.01 clpn_SC_m + h_m + cmp_m h2o_c + cmp_c --> csn_c + r5p_c co2_e <=> co2_c co2_c <=> co2_g co2_c <=> co2_m co2_n <=> co2_c co2_c <=> co2_x co2_c <=> co2_v h2o_x + coa_x --> 2.0 h_x + pan4p_x + pap_x coa_c --> coa_m coa_c <=> coa_n T4hcinnm_m + atp_m + coa_m --> coucoa_m + amp_m + ppi_m 2.0 h_c + o2_c + cpppg3_c --> 2.0 h2o_c + pppg9_c + 2.0 co2_c acrn_c + crn_m --> crn_c + acrn_m crn_c + acrn_x --> acrn_c + crn_x crn_e <=> crn_c crn_m --> crn_c crn_c --> crn_x acrn_m + coa_m <=> crn_m + accoa_m crn_x + accoa_x <=> coa_x + acrn_x accoa_c + crn_c <=> acrn_c + coa_c h_c + h2o_c + csn_c --> ura_c + nh4_c h_e + csn_e --> h_c + csn_c oaa_m + accoa_m + h2o_m --> h_m + cit_m + coa_m h2o_x + oaa_x + accoa_x --> h_x + cit_x + coa_x atp_c + nh4_c + utp_c --> adp_c + pi_c + ctp_c + 2.0 h_c atp_c + h2o_c + gln_L_c + utp_c --> adp_c + pi_c + ctp_c + 2.0 h_c + glu_L_c ctp_c + 2.0 h_c + cmp_m --> 2.0 h_m + ctp_m + cmp_c 6.0 h_m + o2_m + 4.0 focytc_m --> 6.0 h_c + 4.0 ficytc_m + 2.0 h2o_m 1.5 h_m + 2.0 ficytc_m + q6h2_m --> q6_m + 1.5 h_c + 2.0 focytc_m acser_c + h2s_c --> ac_c + h_c + cys_L_c h2o_c + cyst_L_c --> 2obut_c + cys_L_c + nh4_c h2o_c + cyst_L_c --> pyr_c + nh4_c + hcys_L_c cyst_L_x + h2o_x --> nh4_x + pyr_x + hcys_L_x atp_c + trnacys_c + cys_L_c --> amp_c + ppi_c + cystrna_c ser_L_c + hcys_L_c --> h2o_c + cyst_L_c cyst_L_c <=> cyst_L_x cys_L_e + h_e <=> h_c + cys_L_c h_c + cytd_c + h2o_c --> nh4_c + uri_c gtp_c + cytd_c --> h_c + gdp_c + cmp_c h_e + cytd_e --> h_c + cytd_c atp_c + cmp_c <=> adp_c + cdp_c atp_c + dcmp_c <=> adp_c + dcdp_c h_c + h2o_c + dad_2_c --> nh4_c + din_c damp_c + atp_c <=> adp_c + dadp_c dad_2_e + h_e --> h_c + dad_2_c dadp_c <=> dadp_n 0.01 12dgr_SC_c + cdpchol_c --> h_c + 0.01 pc_SC_c + cmp_c 0.01 pa_SC_c + h2o_c --> 0.01 12dgr_SC_c + pi_c h_e + dann_e <=> h_c + dann_c h_c + 0.01 pa_SC_c + ctp_c <=> 0.01 cdpdag_SC_c + ppi_c h_m + ctp_m + 0.01 pa_SC_m <=> 0.01 cdpdag_SC_m + ppi_m ru5p_D_c --> h_c + for_c + db4p_c atp_c + co2_c + dann_c <=> adp_c + dtbt_c + pi_c + 3.0 h_c dcdp_c <=> dcdp_n h_c + h2o_c + dcmp_c <=> dump_c + nh4_c h_c + h2o_c + dctp_c --> dutp_c + nh4_c h_c + h2o_c + dcyt_c --> duri_c + nh4_c h_e + dcyt_e --> h_c + dcyt_c h2o_c + e4p_c + pep_c --> 2dda7p_c + pi_c h2o_m + e4p_m + pep_m --> pi_m + 2dda7p_m nadph_c + h_c + tdcoa_c + o2_c --> 2.0 h2o_c + tdecoa_c + nadp_c pmtcoa_c + h_c + nadph_c + o2_c --> 2.0 h2o_c + hdcoa_c + nadp_c nadph_c + stcoa_c + h_c + o2_c --> 2.0 h2o_c + odecoa_c + nadp_c nadph_c + odecoa_c + h_c + o2_c --> 2.0 h2o_c + ocdycacoa_c + nadp_c dgdp_c <=> dgdp_n 6dg_c + h2o_c --> glc_D_c + gal_c atp_c + dgmp_c <=> dgdp_c + adp_c dgsn_e + h_e --> h_c + dgsn_c 23dhmb_m --> 3mob_m + h2o_m 23dhmp_m --> h2o_m + 3mop_m dha_c + atp_c --> h_c + dhap_c + adp_c dhap_m --> dhap_c h_c + nadph_c + dhf_c --> thf_c + nadp_c h_m + dhf_m + nadph_m --> nadp_m + thf_m atp_c + dhpt_c + glu_L_c --> adp_c + pi_c + h_c + dhf_c dhf_c <=> dhf_m dhnpt_m --> h_m + 2ahhmp_m + gcald_m dhnpt_c <=> dhnpt_m q6_m + dhor_S_c --> q6h2_m + orot_c fum_c + dhor_S_c --> succ_c + orot_c o2_c + dhor_S_c --> h2o2_c + orot_c h2o_c + dhor_S_c <=> h_c + cbasp_c 4abz_m + 2ahhmp_m --> dhpt_m + h2o_m dhpt_c <=> dhpt_m 2dda7p_c --> pi_c + 3dhq_c 3dhq_c --> h2o_c + 3dhsk_c accoa_c + sprm_c --> h_c + N1sprm_c + coa_c din_e + h_e --> h_c + din_c caphis_c + amet_c --> h_c + cmaphis_c + ahcys_c 3.0 h2o_c + dkmpp_c --> for_c + pi_c + 6.0 h_c + 2kmb_c ipdp_c + dmpp_c --> grdp_c + ppi_c h2o_c + dhpmp_c --> dhnpt_c + pi_c h2o_c + ahdt_c --> h_c + ppi_c + dhpmp_c dolichol_c + ctp_c --> dolp_c + cdp_c + h_c dolmanp_r --> h_r + dolp_r + mannan_r dolp_c + gdpmann_c --> gdp_c + dolmanp_r h_c + dolp_c <=> dolp_r + h_r atp_c + dpcoa_c --> h_c + coa_c + adp_c dpcoa_m + atp_m --> adp_m + h_m + coa_m 13dpg_c <=> h_c + 23dpg_c atp_c + 5dpmev_c --> co2_c + adp_c + pi_c + ipdp_c h_c + 2dhp_c + nadph_c --> nadp_c + pant_R_c h_m + 2dhp_m + nadph_m --> nadp_m + pant_R_m atp_c + drib_c --> h_c + adp_c + 2dr5p_c h_c + 25dhpp_c + nadph_c --> 25dthpp_c + nadp_c h_c + h2o_c + 25dthpp_c --> 5aprbu_c + nh4_c atp_c + dtmp_c <=> dtdp_c + adp_c dttp_e <=> dttp_c dump_c <=> dump_n atp_c + duri_c --> h_c + adp_c + dump_c pi_c + duri_c <=> 2dr1p_c + ura_c duri_e + h_e --> h_c + duri_c h2o_c + dutp_c --> h_c + ppi_c + dump_c h2o_c + spmd_c + q6_m --> 4abutn_c + 13dampp_c + q6h2_m 2.0 ficytc_m + lac_D_c --> pyr_c + 2.0 focytc_m 2.0 ficytc_m + lac_D_m --> pyr_m + 2.0 focytc_m lac_D_e + h_e <=> h_c + lac_D_c pyr_m + lac_D_c <=> pyr_c + lac_D_m h_c + lac_D_c <=> h_m + lac_D_m e4hglu_c <=> e4hglu_m e4hglu_c <=> e4hglu_x e4p_c <=> e4p_m hxc2coa_x + h2o_x <=> 3hxccoa_x 3hdcoa_x <=> h2o_x + dc2coa_x 3hddcoa_x <=> h2o_x + dd2coa_x 3htdcoa_x <=> h2o_x + td2coa_x 3hhdcoa_x <=> hdd2coa_x + h2o_x 3hodcoa_x <=> h2o_x + od2coa_x akg_c + e4hglu_c --> glu_L_c + 4h2oglt_c e4hglu_m + akg_m --> 4h2oglt_m + glu_L_m akg_x + e4hglu_x --> glu_L_x + 4h2oglt_x 2pg_c <=> h2o_c + pep_c pectin_e + h2o_e --> galur_e 0.03 stcoa_c + 0.655 hdcoa_c + 0.02 pmtcoa_c + 0.01 epist_c + 0.27 odecoa_c + 0.01 hexccoa_c + 0.015 tdcoa_c --> coa_c + 0.01 epistest_SC_c h2o_c + 0.01 epistest_SC_c --> 0.27 ocdcea_c + 0.01 epist_c + 0.655 hdcea_c + h_c + 0.015 ttdca_c + 0.01 hexc_c + 0.02 hdca_c + 0.03 ocdca_c 0.01 epistest_SC_e + h2o_e --> 0.02 hdca_e + 0.03 ocdca_e + 0.01 hexc_e + 0.01 epist_e + 0.655 hdcea_e + h_e + 0.015 ttdca_e + 0.27 ocdcea_e epist_e <=> epist_c h2o_c + epm_c <=> man_c + gal_c 0.03 stcoa_c + 0.655 hdcoa_c + 0.02 pmtcoa_c + 0.01 hexccoa_c + 0.27 odecoa_c + 0.01 ergst_c + 0.015 tdcoa_c --> 0.01 ergstest_SC_c + coa_c 0.01 ergstest_SC_c + h2o_c --> 0.27 ocdcea_c + 0.01 ergst_c + h_c + 0.015 ttdca_c + 0.01 hexc_c + 0.655 hdcea_c + 0.02 hdca_c + 0.03 ocdca_c 0.01 ergstest_SC_e + h2o_e --> 0.02 hdca_e + 0.01 hexc_e + 0.03 ocdca_e + 0.01 ergst_e + 0.655 hdcea_e + h_e + 0.015 ttdca_e + 0.27 ocdcea_e ergst_c + udpg_c --> h_c + udp_c + ergst3glc_c ergst_e <=> ergst_c ergst_r <=> ergst_c ergtetrol_c <=> ergtetrol_r atp_c + etha_c --> h_c + adp_c + ethamp_c 0.01 12dgr_SC_c + cdpea_c <=> h_c + 0.01 pe_SC_c + cmp_c etha_e <=> etha_c etoh_e <=> etoh_c etoh_c <=> etoh_m 13BDglcn_e --> 2hb_e --> 2mbac_e --> 2mbald_e --> 2mbtoh_e --> 2mppal_e --> 2phetoh_e --> 3c3hmp_e --> 3mbald_e --> 3mop_e --> 4abut_e --> 4abz_e --> 5aop_e --> 8aonn_e --> Nbfortyr_e --> abt_e --> ac_e --> acald_e --> aces_e --> ade_e --> adn_e --> akg_e --> ala_L_e --> alltn_e --> alltt_e --> amet_e --> arab_D_e --> arab_L_e --> arg_L_e --> asn_L_e --> asp_L_e --> btd_RR_e --> btn_e --> chol_e --> cit_e --> co2_e --> crn_e --> csn_e --> cys_L_e --> cytd_e --> dad_2_e --> dann_e --> dca_e --> dcyt_e --> ddca_e --> dgsn_e --> din_e --> dttp_e --> duri_e --> epist_e --> epistest_SC_e --> ergst_e --> ergstest_SC_e --> etha_e --> etoh_e --> fe2_e <=> fecost_e --> fecostest_SC_e --> fmn_e --> for_e --> fru_e --> fum_e --> g3pc_e --> g3pi_e --> gal_e --> galur_e --> gam6p_e --> gcald_e --> glc_D_e <=> gln_L_e --> glu_L_e --> glx_e --> gly_e --> glyc_e --> gsn_e --> gthox_e --> gthrd_e --> gua_e --> h2o_e <=> h_e <=> hdca_e --> hdcea_e --> hexc_e --> his_L_e --> hxan_e --> iamac_e --> iamoh_e --> ibutac_e --> ibutoh_e --> id3acald_e --> ile_L_e --> ind3eth_e --> inost_e --> ins_e --> k_e <=> lac_D_e --> lac_L_e --> lanost_e --> lanostest_SC_e --> leu_L_e --> lys_L_e --> mal_L_e --> malt_e --> man_e --> melib_e --> met_L_e --> mmet_e --> na1_e <=> nac_e --> nadp_e --> nh4_e <=> nmn_e --> o2_e <=> oaa_e --> ocdca_e --> ocdcea_e --> ocdcya_e --> orn_e --> pacald_e --> pap_e --> pc_SC_e --> pectin_e --> pepd_e --> phe_L_e --> pheac_e --> pi_e <=> pnto_R_e --> pro_L_e --> ptd1ino_SC_e --> ptrc_e --> pyr_e --> rib_D_e --> ribflv_e --> sbt_D_e --> sbt_L_e --> ser_L_e --> so3_e --> so4_e <=> spmd_e --> sprm_e --> srb_L_e --> succ_e --> sucr_e --> taur_e --> thm_e --> thmmp_e --> thmpp_e --> thr_L_e --> thym_e --> thymd_e --> tre_e --> trp_L_e --> ttdca_e --> tyr_L_e --> ura_e --> urea_e --> uri_e --> val_L_e --> xan_e --> xtsn_e --> xyl_D_e --> xylt_e --> zymst_e --> zymstest_SC_e --> dca_c --> dca_x h2o_c + ddcaACP_c <=> h_c + ACP_c + ddca_c ddcaACP_m --> ddcaACP_c ddca_c --> ddca_x myrsACP_c + h2o_c <=> h_c + ttdca_c + ACP_c myrsACP_m --> myrsACP_c atp_x + h2o_x + tdcoa_c --> h_x + tdcoa_x + adp_x + pi_x ttdca_c --> ttdca_x h2o_c + tdeACP_c <=> h_c + ttdcea_c + ACP_c tdeACP_m --> tdeACP_c atp_x + h2o_x + tdecoa_c --> h_x + tdecoa_x + adp_x + pi_x ttdcea_c --> ttdcea_x h2o_c + palmACP_c <=> h_c + hdca_c + ACP_c palmACP_m --> palmACP_c atp_x + h2o_x + pmtcoa_c --> h_x + adp_x + pmtcoa_x + pi_x hdca_c --> hdca_x h2o_c + hdeACP_c <=> h_c + ACP_c + hdcea_c hdeACP_m --> hdeACP_c hdcoa_c + atp_x + h2o_x --> h_x + adp_x + hdcoa_x + pi_x hdcea_c --> hdcea_x ocdcaACP_c + h2o_c <=> h_c + ocdca_c + ACP_c ocdcaACP_m --> ocdcaACP_c atp_x + h2o_x + stcoa_c --> h_x + adp_x + stcoa_x + pi_x h2o_c + octeACP_c <=> h_c + ACP_c + ocdcea_c octeACP_m --> octeACP_c atp_x + odecoa_c + h2o_x --> h_x + adp_x + odecoa_x + pi_x h2o_c + ocdcyaACP_c <=> h_c + ACP_c + ocdcya_c ocdcyaACP_m --> ocdcyaACP_c atp_x + h2o_x + ocdycacoa_c --> h_x + adp_x + pi_x + ocdycacoa_x ttc_c --> ttc_x hexc_c --> hexc_x octa_c --> octa_x coa_x + dca_x + atp_x <=> amp_x + ppi_x + dcacoa_x ddca_x + coa_x + atp_x <=> amp_x + ppi_x + ddcacoa_x atp_c + ttdca_c + coa_c <=> amp_c + ppi_c + tdcoa_c ttdca_x + coa_x + atp_x <=> amp_x + tdcoa_x + ppi_x atp_c + ttdcea_c + coa_c <=> amp_c + ppi_c + tdecoa_c ttdcea_x + coa_x + atp_x <=> tdecoa_x + amp_x + ppi_x atp_c + coa_c + hdca_c <=> pmtcoa_c + amp_c + ppi_c hdca_x + coa_x + atp_x <=> amp_x + pmtcoa_x + ppi_x atp_c + hdcea_c + coa_c <=> hdcoa_c + amp_c + ppi_c coa_x + atp_x + hdcea_x <=> amp_x + ppi_x + hdcoa_x atp_c + coa_c + ocdca_c <=> stcoa_c + amp_c + ppi_c atp_c + ocdcea_c + coa_c <=> odecoa_c + amp_c + ppi_c atp_c + ocdcya_c + coa_c <=> amp_c + ppi_c + ocdycacoa_c coa_x + ttc_x + atp_x <=> amp_x + ppi_x + ttccoa_x hexc_x + coa_x + atp_x <=> amp_x + ppi_x + hexccoa_x coa_x + octa_x + atp_x <=> amp_x + occoa_x + ppi_x fmn_m + fad_c --> fmn_c + fad_m gthrd_c + fald_c + nad_c <=> h_c + Sfglutth_c + nadh_c tdecoa_x + nadph_x + 6.0 coa_x + 6.0 h2o_x + 6.0 nad_x + 6.0 o2_x --> 5.0 h_x + 6.0 nadh_x + 6.0 h2o2_x + 7.0 accoa_x + nadp_x tdecoa_x + 6.0 coa_x + 6.0 h2o_x + 6.0 nad_x + 5.0 o2_x --> 6.0 h_x + 6.0 nadh_x + 5.0 h2o2_x + 7.0 accoa_x nadph_x + hdcoa_x + 7.0 coa_x + 7.0 h2o_x + 7.0 nad_x + 7.0 o2_x --> 6.0 h_x + 7.0 nadh_x + 7.0 h2o2_x + 8.0 accoa_x + nadp_x hdcoa_x + 7.0 coa_x + 7.0 h2o_x + 7.0 nad_x + 6.0 o2_x --> 7.0 h_x + 7.0 nadh_x + 6.0 h2o2_x + 8.0 accoa_x 8.0 coa_x + 8.0 h2o_x + odecoa_x + 8.0 nad_x + 8.0 o2_x + nadph_x --> 7.0 h_x + nadp_x + 8.0 nadh_x + 9.0 accoa_x + 8.0 h2o2_x 8.0 coa_x + 8.0 h2o_x + odecoa_x + 8.0 nad_x + 7.0 o2_x --> 8.0 h_x + 8.0 nadh_x + 7.0 h2o2_x + 9.0 accoa_x ocdycacoa_x + 8.0 coa_x + 8.0 h2o_x + 8.0 nad_x + 8.0 o2_x + 2.0 nadph_x --> 6.0 h_x + 8.0 nadh_x + 2.0 nadp_x + 9.0 accoa_x + 8.0 h2o2_x ocdycacoa_x + 8.0 coa_x + 8.0 h2o_x + 8.0 nad_x + 7.0 o2_x + nadph_x --> 7.0 h_x + 8.0 nadh_x + nadp_x + 9.0 accoa_x + 7.0 h2o2_x ocdycacoa_x + 8.0 coa_x + 8.0 h2o_x + 8.0 nad_x + 6.0 o2_x --> 8.0 h_x + 8.0 nadh_x + 6.0 h2o2_x + 9.0 accoa_x ttccoa_x + 3.0 coa_x + 3.0 h2o_x + 3.0 nad_x + 3.0 o2_x --> 3.0 h_x + 3.0 nadh_x + stcoa_x + 3.0 h2o2_x + 3.0 accoa_x occoa_x + 3.0 coa_x + 3.0 h2o_x + 3.0 nad_x + 3.0 o2_x --> 3.0 h_x + 3.0 nadh_x + 3.0 h2o2_x + 4.0 accoa_x 2.0 nadph_c + octa_c + 3.0 h_c + malcoa_c --> dca_c + h2o_c + co2_c + coa_c + 2.0 nadp_c 3.0 h_m + 2.0 nadph_m + malACP_m + ocACP_m --> 2.0 nadp_m + ACP_m + h2o_m + co2_m + dcaACP_m 2.0 nadph_c + occoa_c + 3.0 h_c + malcoa_c --> co2_c + h2o_c + coa_c + dcacoa_c + 2.0 nadp_c dca_c + 2.0 nadph_c + 3.0 h_c + malcoa_c --> h2o_c + co2_c + ddca_c + coa_c + 2.0 nadp_c 3.0 h_m + 2.0 nadph_m + malACP_m + dcaACP_m --> ddcaACP_m + 2.0 nadp_m + ACP_m + h2o_m + co2_m 2.0 nadph_c + 3.0 h_c + dcacoa_c + malcoa_c --> co2_c + ddcacoa_c + h2o_c + coa_c + 2.0 nadp_c 2.0 nadph_c + ddca_c + 3.0 h_c + malcoa_c --> co2_c + h2o_c + ttdca_c + coa_c + 2.0 nadp_c 3.0 h_m + 2.0 nadph_m + ddcaACP_m + malACP_m --> 2.0 nadp_m + ACP_m + h2o_m + co2_m + myrsACP_m 2.0 nadph_c + ddcacoa_c + 3.0 h_c + malcoa_c --> co2_c + h2o_c + coa_c + tdcoa_c + 2.0 nadp_c 3.0 nadph_c + 4.0 h_c + ddca_c + o2_c + malcoa_c --> co2_c + ttdcea_c + 3.0 h2o_c + coa_c + 3.0 nadp_c 3.0 nadph_m + o2_m + ddcaACP_m + malACP_m + 4.0 h_m --> 3.0 nadp_m + ACP_m + tdeACP_m + 3.0 h2o_m + co2_m 2.0 nadph_c + 3.0 h_c + ttdca_c + malcoa_c --> co2_c + h2o_c + coa_c + hdca_c + 2.0 nadp_c 3.0 h_m + myrsACP_m + 2.0 nadph_m + malACP_m --> 2.0 nadp_m + ACP_m + h2o_m + co2_m + palmACP_m 2.0 nadph_c + 3.0 h_c + tdcoa_c + malcoa_c --> co2_c + h2o_c + coa_c + 2.0 nadp_c + pmtcoa_c 3.0 nadph_c + 4.0 h_c + ttdca_c + o2_c + malcoa_c --> co2_c + 3.0 h2o_c + coa_c + hdcea_c + 3.0 nadp_c 4.0 h_m + o2_m + 3.0 nadph_m + malACP_m + myrsACP_m --> 3.0 nadp_m + ACP_m + 3.0 h2o_m + co2_m + hdeACP_m 2.0 nadph_c + 3.0 h_c + malcoa_c + hdca_c --> co2_c + h2o_c + coa_c + 2.0 nadp_c + ocdca_c 3.0 h_m + 2.0 nadph_m + malACP_m + palmACP_m --> h2o_m + 2.0 nadp_m + ACP_m + ocdcaACP_m + co2_m 2.0 nadph_c + 3.0 h_c + pmtcoa_c + malcoa_c --> co2_c + stcoa_c + h2o_c + coa_c + 2.0 nadp_c 3.0 nadph_c + 4.0 h_c + hdca_c + o2_c + malcoa_c --> co2_c + 3.0 h2o_c + ocdcea_c + coa_c + 3.0 nadp_c 4.0 h_m + o2_m + 3.0 nadph_m + malACP_m + palmACP_m --> octeACP_m + 3.0 nadp_m + ACP_m + 3.0 h2o_m + co2_m 5.0 h_m + 2.0 o2_m + 4.0 nadph_m + malACP_m + palmACP_m --> ocdcyaACP_m + 4.0 nadp_m + ACP_m + 5.0 h2o_m + co2_m 6.0 nadph_c + 9.0 h_c + 3.0 malcoa_c + ocdca_c --> 3.0 co2_c + 3.0 h2o_c + 3.0 coa_c + ttc_c + 6.0 nadp_c 2.0 nadph_c + 3.0 h_c + ttc_c + malcoa_c --> co2_c + coa_c + h2o_c + hexc_c + 2.0 nadp_c 9.0 h_m + acACP_m + 6.0 nadph_m + 3.0 malACP_m --> 6.0 nadp_m + 3.0 ACP_m + 3.0 h2o_m + 3.0 co2_m + ocACP_m 6.0 nadph_c + accoa_c + 9.0 h_c + 3.0 malcoa_c --> occoa_c + 3.0 h2o_c + 3.0 co2_c + 3.0 coa_c + 6.0 nadp_c 6.0 nadph_c + accoa_c + 8.0 h_c + 3.0 malcoa_c --> 3.0 co2_c + octa_c + 2.0 h2o_c + 4.0 coa_c + 6.0 nadp_c fdp_c <=> g3p_c + dhap_c f1p_c <=> dhap_c + glyald_c s17bp_c <=> e4p_c + dhap_c h2o_c + fdp_c --> pi_c + f6p_c h2o_c + f26bp_c --> pi_c + f6p_c fe2_m + ppp9_m --> pheme_m + 2.0 h_m for_c + nad_c --> co2_c + nadh_c h_c + for_c + q6_m --> co2_c + q6h2_m fe2_e --> fe2_c fe2_c --> fe2_m 0.655 hdcoa_c + 0.02 pmtcoa_c + 0.01 hexccoa_c + 0.27 odecoa_c + 0.01 fecost_c + 0.03 stcoa_c + 0.015 tdcoa_c --> coa_c + 0.01 fecostest_SC_c 0.01 fecostest_SC_c + h2o_c --> 0.27 ocdcea_c + h_c + 0.01 fecost_c + 0.015 ttdca_c + 0.01 hexc_c + 0.655 hdcea_c + 0.02 hdca_c + 0.03 ocdca_c 0.01 fecostest_SC_e + h2o_e --> 0.02 hdca_e + 0.03 ocdca_e + 0.01 hexc_e + 0.655 hdcea_e + h_e + 0.01 fecost_e + 0.015 ttdca_e + 0.27 ocdcea_e fecost_e <=> fecost_c fe2_m --> fe2_c h2o_c + Lfmkynr_c --> h_c + for_c + Lkynr_c mettrna_m + 10fthf_m --> h_m + thf_m + fmettrna_m h_c + fmn_c + atp_c --> ppi_c + fad_c fmn_m + h_m + atp_m --> fad_m + ppi_m h_c + fmn_c + nadh_c --> fmnh2_c + nad_c h_c + fmn_c + nadph_c --> fmnh2_c + nadp_c 4abz_m + 2ahhmd_m --> dhpt_m + ppi_m for_e <=> for_c for_m --> for_c frdp_c <=> frdp_m fum_c + fadh2_m --> fad_m + succ_c fum_m + fadh2_m --> fad_m + succ_m ipdp_c + frdp_c --> ggdp_c + ppi_c atp_c + f1p_c --> h_c + fdp_c + adp_c h_e + fru_e --> h_c + fru_c 5fthf_c + atp_c --> adp_c + pi_c + methf_c 5fthf_m + atp_m --> pi_m + adp_m + methf_m atp_c + 5fthf_c + h2o_c --> adp_c + pi_c + h_c + 10fthf_c atp_c + for_c + thf_c --> pi_c + 10fthf_c + adp_c thf_m + for_m + atp_m --> pi_m + adp_m + 10fthf_m h2o_c + fum_c <=> mal_L_c h2o_c + 4fumacac_c --> h_c + fum_c + acac_c fum_m + h2o_m <=> mal_L_m h_e + fum_e <=> h_c + fum_c m2macchitppdol_g + gdpmann_g --> m3macchitppdol_g + gdp_g + h_g gdpmann_g + m3macchitppdol_g --> m4macchitppdol_g + gdp_g + h_g gdpmann_g + macchitppdol_g --> m1macchitppdol_g + gdp_g + h_g gdpmann_g + m1macchitppdol_g --> m2macchitppdol_g + gdp_g + h_g g3pc_e <=> g3pc_c h_c + dhap_c + nadh_c --> glyc3p_c + nad_c nadh_m + h_m + dhap_m --> nad_m + glyc3p_m fad_m + glyc3p_m --> fadh2_m + dhap_m g3pi_e <=> g3pi_c glyc3p_c + h2o_c --> pi_c + glyc_c glu5sa_c <=> h_c + h2o_c + 1pyr5c_c glu5sa_m <=> h_m + h2o_m + 1pyr5c_m nadph_c + h_c + glu5p_c --> glu5sa_c + pi_c + nadp_c glu5p_c + h_c + nadh_c --> glu5sa_c + pi_c + nad_c h2o_c + gam6p_c --> nh4_c + f6p_c g6p_c + nadp_c --> h_c + nadph_c + 6pgl_c g6p_r + nadp_r --> nadph_r + 6pgl_r + h_r g6p_c <=> g6p_B_c g6p_B_c <=> f6p_c g6p_c <=> g6p_r 1Dgali_c + h2o_c <=> gal_c + inost_c atp_c + gal_c --> h_c + adp_c + gal1p_c melib_c + h2o_c --> glc_D_c + gal_c h_c + gal1p_c + utp_c <=> udpgal_c + ppi_c h_c + g1p_c + utp_c <=> ppi_c + udpg_c h_e + gal_e --> h_c + gal_c gam6p_e <=> gam6p_c g3p_c + pi_c + nad_c <=> h_c + 13dpg_c + nadh_c gar_c + 10fthf_c --> h_c + thf_c + fgam_c 0.17 hdcoa_c + 0.27 pmtcoa_c + 0.06 ddcacoa_c + 0.24 odecoa_c + glyc3p_c + 0.05 stcoa_c + 0.02 dcacoa_c + 0.09 ocdycacoa_c + 0.1 tdcoa_c --> coa_c + 0.01 1ag3p_SC_c 0.17 hdcoa_c + 0.27 pmtcoa_c + dhap_c + 0.06 ddcacoa_c + 0.24 odecoa_c + 0.05 stcoa_c + 0.02 dcacoa_c + 0.09 ocdycacoa_c + 0.1 tdcoa_c --> 0.01 1agly3p_SC_c + coa_c 14glun_c --> glycogen_c + h2o_c gcald_e <=> gcald_c gcald_c <=> gcald_m lpam_m + h_m + gly_m <=> alpam_m + co2_m alpam_m + thf_m --> dhlam_m + mlthf_m + nh4_m dhlam_m + nad_m <=> lpam_m + nadh_m + h_m lpro_m + h_m + gly_m <=> alpro_m + co2_m alpro_m + thf_m --> mlthf_m + nh4_m + dhlpro_m nad_m + dhlpro_m <=> nadh_m + lpro_m + h_m gmp_g + gdpmann_c --> gmp_c + gdpmann_g h_c + gdp_g <=> gdp_c + h_g gdp_c <=> gdp_n f6p_c + gln_L_c --> glu_L_c + gam6p_c h2o_c + ggl_c <=> glyc_c + gal_c ggdp_c + ipdp_c --> pendp_c + ppi_c thf_c + ser_L_c <=> mlthf_c + h2o_c + gly_c thf_m + ser_L_m <=> gly_m + mlthf_m + h2o_m gmp_c + atp_c <=> adp_c + gdp_c gmp_c + datp_c <=> gdp_c + dadp_c h2o_c + glycogen_c --> glc_D_c h2o_v + glycogen_v --> glc_D_v glycogen_c --> glycogen_v pi_c + glycogen_c --> g1p_c udpg_c --> h_c + udp_c + glycogen_c glc_D_e --> glc_D_c glc_D_c <=> glc_D_v atp_c + nh4_c + glu_L_c --> adp_c + pi_c + h_c + gln_L_c atp_c + trnagln_c + gln_L_c --> amp_c + ppi_c + glntrna_c h_c + gln_L_c <=> gln_L_n + h_n gln_L_e + h_e <=> h_c + gln_L_c h_v + gln_L_c --> h_c + gln_L_v h_v + gln_L_v --> h_c + gln_L_c glp_c + tdcoa_c --> coa_c + tglp_c atp_c + glu_L_c --> glu5p_c + adp_c atp_c + glu_L_c + cys_L_c --> adp_c + glucys_c + pi_c + h_c h_c + glu_L_c --> co2_c + 4abut_c h2o_c + glu_L_c + nad_c --> akg_c + nh4_c + h_c + nadh_c akg_c + nadph_c + nh4_c + h_c --> h2o_c + glu_L_c + nadp_c glc_D_c + atp_c --> h_c + g6p_B_c + adp_c h2o_c + gln_L_c --> glu_L_c + nh4_c h2o_c + gln_L_c + prpp_c --> pram_c + ppi_c + glu_L_c akg_c + h_c + gln_L_c + nadh_c --> nad_c + 2.0 glu_L_c atp_c + glu_L_c + trnaglu_c --> glutrna_c + amp_c + ppi_c trnaglu_m + glu_L_m + atp_m --> amp_m + glutrna_m + ppi_m h_c + glu_L_c <=> h_n + glu_L_n glu_L_e + h_e <=> h_c + glu_L_c oh1_m + glu_L_c --> glu_L_m + oh1_c glu_L_v + h_v --> h_c + glu_L_c glu_L_c --> glu_L_m glx_c <=> glx_e glx_c <=> glx_x coa_c + 2aobut_c --> accoa_c + gly_c glyc3p_c --> glyc3p_m nadp_c + glyc_c --> h_c + dha_c + nadph_c gly_m + nad_m + thf_m --> nadh_m + mlthf_m + co2_m + nh4_m glyc_c <=> glyc_e glyc_e + h_e --> h_c + glyc_c udpg_c + h2o_c --> h_c + 14glun_c + udp_c atp_c + glyc_c --> h_c + glyc3p_c + adp_c h2o_c + lgt_S_c --> h_c + gthrd_c + lac_D_c h2o_m + lgt_S_m --> h_m + gthrd_m + lac_D_m atp_c + trnagly_c + gly_c --> amp_c + ppi_c + glytrna_c h_c + gly_c <=> gly_m + h_m h_e + gly_e <=> h_c + gly_c xmp_c + h2o_c + atp_c + gln_L_c --> gmp_c + 2.0 h_c + amp_c + ppi_c + glu_L_c 6pgc_c + nadp_c --> co2_c + nadph_c + ru5p_D_c h2o_c + gsn_c --> gua_c + rib_D_c g3pc_c + h2o_c --> glyc3p_c + h_c + chol_c ipdp_c + grdp_c --> frdp_c + ppi_c atp_c + gsn_c --> h_c + adp_c + gmp_c gsn_e + h_e --> h_c + gsn_c h_c + gsn_c <=> h_m + gsn_m h_c + gthox_c + nadph_c --> 2.0 gthrd_c + nadp_c gthox_e --> gthox_c gthox_m + h_m + nadph_m --> nadp_m + 2.0 gthrd_m 2.0 gthrd_c + h2o2_c <=> gthox_c + 2.0 h2o_c 2.0 gthrd_m + h2o2_m <=> gthox_m + 2.0 h2o_m gthrd_c + h2o_v + atp_v --> adp_v + gthrd_v + pi_v + h_v gthrd_e --> gthrd_c atp_c + glucys_c + gly_c --> adp_c + gthrd_c + pi_c + h_c gthrd_c + ala_L_c --> gluala_c + cgly_c gtp_c + h2o_c --> h_c + for_c + ahdt_c gtp_c + 3.0 h2o_c --> for_c + 2.0 h_c + 25dhpp_c + ppi_c gtp_c + 2.0 h2o_c --> 2.0 h_c + gmp_c + 2.0 pi_c gtp_c + h_c + gdp_m --> gdp_c + gtp_m + h_m h_c + h2o_c + gua_c --> xan_c + nh4_c gua_c + prpp_c --> gmp_c + ppi_c h_e + gua_e <=> h_c + gua_c gua_c <=> gua_m h2o2_c <=> h2o2_n h2o_e <=> h2o_c h2o_c <=> h2o_r h2o_c <=> h2o_m h2o_n <=> h2o_c h2o_c <=> h2o_x h2o_c <=> h2o_v 3hxccoa_x + nad_x <=> h_x + 3ohxccoa_x + nadh_x h_x + nadh_x + 3odcoa_x <=> nad_x + 3hdcoa_x h_x + nadh_x + 3oddcoa_x <=> nad_x + 3hddcoa_x 3otdcoa_x + nadh_x + h_x <=> nad_x + 3htdcoa_x h_x + nadh_x + 3ohdcoa_x <=> 3hhdcoa_x + nad_x h_x + nadh_x + 3ohodcoa_x <=> nad_x + 3hodcoa_x h2o_m + b124tc_m <=> hicit_m hexdp_m + 4hbz_m --> 3ophb_5_m + ppi_m akg_m + accoa_m + h2o_m --> h_m + hcit_m + coa_m akg_n + accoa_n + h2o_n --> coa_n + h_n + hcit_n co2_c + h2o_c <=> h_c + hco3_c h2o_m + co2_m <=> h_m + hco3_m h2o_n + co2_n <=> hco3_n + h_n hco3_c <=> hco3_n hcys_L_c + amet_c --> h_c + met_L_c + ahcys_c h_c + hcys_L_c <=> hcys_L_x + h_x hdca_e --> hdca_c hdcea_e --> hdcea_c nadh_m + o2_m + hemeO_m --> nad_m + hemeA_m + h2o_m pheme_m + h2o_m + frdp_m --> hemeO_m + ppi_m 4mhetz_c + atp_c --> h_c + adp_c + 4mpetz_c atp_c + glc_D_c --> h_c + g6p_c + adp_c atp_c + man_c --> h_c + adp_c + man6p_c atp_c + fru_c --> h_c + adp_c + f6p_c hexccoa_c <=> hexccoa_x hexdp_c <=> hexdp_m o2_c + hgentis_c --> h_c + 4mlacac_c hicit_m + nad_m <=> nadh_m + h_m + oxag_m h2o_c + 2.0 nad_c + histd_c --> his_L_c + 3.0 h_c + 2.0 nadh_c h2o_c + hisp_c --> pi_c + histd_c atp_c + trnahis_c + his_L_c --> histrna_c + amp_c + ppi_c his_L_m + atp_m + trnahis_m --> histrna_m + amp_m + ppi_m h_m + his_L_m <=> h_c + his_L_c his_L_e + h_e <=> h_c + his_L_c h_v + his_L_c --> h_c + his_L_v hLkynr_c + h2o_c --> 3hanthrn_c + ala_L_c 4.0 ppbng_c + h2o_c --> 4.0 nh4_c + hmbil_c mev_R_c + coa_c + 2.0 nadp_c <=> 2.0 nadph_c + 2.0 h_c + hmgcoa_c h_c + coa_c + hmgcoa_c <=> h2o_c + accoa_c + aacoa_c hmgcoa_m + h_m + coa_m <=> accoa_m + h2o_m + aacoa_m hmgcoa_c <=> hmgcoa_m atp_c + 4ahmmp_c --> h_c + adp_c + 4ampm_c 2ahhmp_m + atp_m --> amp_m + 2ahhmd_m + h_m 2.0 h_c + 1p3h5c_c + nadh_c --> nad_c + 4hpro_LT_c 2.0 h_c + nadph_c + 1p3h5c_c --> nadp_c + 4hpro_LT_c nad_m + 4hpro_LT_m --> nadh_m + 2.0 h_m + 1p3h5c_m nadp_m + 4hpro_LT_m --> 2.0 h_m + 1p3h5c_m + nadph_m h_c + aspsa_c + nadh_c --> hom_L_c + nad_c h_c + nadph_c + aspsa_c --> hom_L_c + nadp_c hom_L_c + accoa_c <=> achms_c + coa_c atp_c + hom_L_c --> h_c + phom_c + adp_c glu_L_c + imacp_c --> akg_c + hisp_c h_e + hxan_e <=> h_c + hxan_c prpp_c + hxan_c --> ppi_c + imp_c pyam5p_c + h2o_c --> pydam_c + pi_c iamac_c --> iamac_e iamoh_c <=> iamoh_e iamoh_c <=> iamoh_m ibutac_c --> ibutac_e ibutoh_c <=> ibutoh_e ibutoh_c <=> ibutoh_m nad_m + icit_m --> nadh_m + co2_m + akg_m icit_c + nadp_c --> akg_c + co2_c + nadph_c nadp_m + icit_m --> co2_m + nadph_m + akg_m icit_x + nadp_x --> co2_x + nadph_x + akg_x icit_c --> succ_c + glx_c id3acald_c <=> id3acald_e id3acald_c <=> id3acald_m prlp_c + gln_L_c --> eig3p_c + h_c + aicar_c + glu_L_c eig3p_c --> h2o_c + imacp_c h_c + 2cpr5p_c --> co2_c + 3ig3p_c + h2o_c akg_c + ile_L_c <=> glu_L_c + 3mop_c ile_L_m + akg_m <=> glu_L_m + 3mop_m atp_c + ile_L_c + trnaile_c --> iletrna_c + amp_c + ppi_c ile_L_m + trnaile_m + atp_m --> iletrna_m + amp_m + ppi_m h_e + ile_L_e <=> h_c + ile_L_c ile_L_c + h_v --> h_c + ile_L_v ile_L_v + h_v --> h_c + ile_L_c ile_L_m --> ile_L_c h2o_c + imp_c <=> fprica_c h2o_c + imp_c + nad_c --> xmp_c + h_c + nadh_c ind3ac_c <=> ind3ac_m ind3eth_c <=> ind3eth_e ind3eth_c <=> ind3eth_m h_c + indpyr_c <=> co2_c + id3acald_c atp_c + ins_c --> h_c + adp_c + imp_c inost_e + h_e --> h_c + inost_c ins_e + h_e --> h_c + ins_c h2o_c + 0.01 ipc124_SC_c --> h_c + cer1_24_c + mi1p_D_c h2o_c + 0.01 ipc126_SC_c --> h_c + cer1_26_c + mi1p_D_c 0.01 ipc224_SC_c + h2o_c --> mi1p_D_c + h_c + cer2_24_c h2o_c + 0.01 ipc226_SC_c --> h_c + cer2_26_c + mi1p_D_c 0.01 ipc324_SC_c + h2o_c --> h_c + mi1p_D_c + cer3_24_c 0.01 ipc326_SC_c + h2o_c --> mi1p_D_c + h_c + cer3_26_c cer1_24_c + 0.01 ptd1ino_SC_c --> 0.01 12dgr_SC_c + 0.01 ipc124_SC_c cer1_26_c + 0.01 ptd1ino_SC_c --> 0.01 12dgr_SC_c + 0.01 ipc126_SC_c cer2_24_c + 0.01 ptd1ino_SC_c --> 0.01 12dgr_SC_c + 0.01 ipc224_SC_c cer2_26_c + 0.01 ptd1ino_SC_c --> 0.01 12dgr_SC_c + 0.01 ipc226_SC_c cer3_24_c + 0.01 ptd1ino_SC_c --> 0.01 12dgr_SC_c + 0.01 ipc324_SC_c 0.01 ptd1ino_SC_c + cer3_26_c --> 0.01 12dgr_SC_c + 0.01 ipc326_SC_c ipdp_c <=> dmpp_c ipdp_c <=> ipdp_m 3c2hmp_c + nad_c --> h_c + 3c4mop_c + nadh_c 3c2hmp_c <=> h2o_c + 2ippm_c h2o_c + 2ippm_c <=> 3c3hmp_c h2o_c + accoa_c + 3mob_c --> h_c + coa_c + 3c3hmp_c 3mob_m + accoa_m + h2o_m --> h_m + 3c3hmp_m + coa_m itacon_m + atp_m + coa_m <=> pi_m + itaccoa_m + adp_m h_m + nadph_m + alac_S_m --> nadp_m + 23dhmb_m 2ahbut_m + h_m + nadph_m --> nadp_m + 23dhmp_m h2o_c + Lkynr_c --> h_c + ala_L_c + anth_c nadph_c + Lkynr_c + h_c + o2_c --> h2o_c + hLkynr_c + nadp_c k_e + h_e <=> h_c + k_c h_c + nadph_c + mthgxl_c --> lald_L_c + nadp_c 0.655 hdcoa_c + 0.02 pmtcoa_c + 0.01 hexccoa_c + 0.27 odecoa_c + 0.03 stcoa_c + 0.01 lanost_c + 0.015 tdcoa_c --> 0.01 lanostest_SC_c + coa_c h2o_c + 0.01 lanostest_SC_c --> 0.27 ocdcea_c + 0.655 hdcea_c + h_c + 0.015 ttdca_c + 0.01 hexc_c + 0.02 hdca_c + 0.01 lanost_c + 0.03 ocdca_c 0.01 lanostest_SC_e + h2o_e --> 0.02 hdca_e + 0.03 ocdca_e + 0.01 hexc_e + 0.01 lanost_e + h_e + 0.015 ttdca_e + 0.655 hdcea_e + 0.27 ocdcea_e lanost_e <=> lanost_c h2o_c + lald_L_c + nad_c --> lac_L_c + 2.0 h_c + nadh_c Lcystin_v + h_v --> h_c + Lcystin_c akg_c + leu_L_c <=> 4mop_c + glu_L_c leu_L_m + akg_m <=> 4mop_m + glu_L_m atp_c + trnaleu_c + leu_L_c --> amp_c + ppi_c + leutrna_c leu_L_m + atp_m + trnaleu_m --> ppi_m + amp_m + leutrna_m leu_L_e + h_e <=> h_c + leu_L_c leu_L_c + h_v --> h_c + leu_L_v h_v + leu_L_v --> h_c + leu_L_c gthrd_c + mthgxl_c --> lgt_S_c lanost_c + 2.0 h_c + 3.0 nadph_c + 3.0 o2_c --> 4.0 h2o_c + for_c + 44mctr_c + 3.0 nadp_c 3.0 o2_c + 2.0 h_c + lanost_c + 3.0 nadh_c --> 4.0 h2o_c + for_c + 44mctr_c + 3.0 nad_c Ssq23epx_c --> lanost_c 0.17 hdcoa_c + 0.27 pmtcoa_c + 0.01 1agpc_SC_c + 0.06 ddcacoa_c + 0.24 odecoa_c + 0.05 stcoa_c + 0.02 dcacoa_c + 0.09 ocdycacoa_c + 0.1 tdcoa_c --> 0.01 pc_SC_c + coa_c 0.01 dagpy_SC_c + h2o_c --> h_c + 0.01 pa_SC_c + pi_c nadp_c + ser_L_c <=> h_c + nadph_c + 2amsa_c atp_c + trnalys_c + lys_L_c --> amp_c + ppi_c + lystrna_c trnalys_m + lys_L_m + atp_m --> lystrna_m + amp_m + ppi_m h_c + lys_L_c <=> h_m + lys_L_m h_e + lys_L_e <=> h_c + lys_L_c h_v + lys_L_c --> h_c + lys_L_v lac_L_c + 2.0 ficytc_m --> pyr_c + 2.0 focytc_m h_e + lac_L_e <=> h_c + lac_L_c h_c + lac_L_c <=> h_m + lac_L_m 4mlacac_c --> 4fumacac_c mal_L_x + oaa_c <=> oaa_x + mal_L_c h2o_c + accoa_c + glx_c --> h_c + coa_c + mal_L_c glx_x + h2o_x + accoa_x --> h_x + coa_x + mal_L_x h2o_c + malt_c --> 2.0 glc_D_c malt_e + h_e --> h_c + malt_c h_e + mal_L_e <=> h_c + mal_L_c pi_m + mal_L_c <=> mal_L_m + pi_c h_c + gtp_c + man1p_c --> ppi_c + gdpmann_c man6p_c <=> f6p_c mannan_c <=> mannan_r h_e + man_e --> h_c + man_c hcit_m <=> h2o_m + b124tc_m micit_m --> pyr_m + succ_m ppcoa_m + oaa_m + h2o_m --> h_m + 2mcit_m + coa_m ACP_c + malcoa_c <=> coa_c + malACP_c malcoa_m + ACP_m <=> malACP_m + coa_m mal_L_c + nad_c <=> h_c + nadh_c + oaa_c mal_L_m + nad_m <=> nadh_m + h_m + oaa_m mal_L_x + nad_x <=> nadh_x + oaa_x + h_x 5mdru1p_c --> h2o_c + dkmpp_c mal_L_m + nad_m --> pyr_m + nadh_m + co2_m mal_L_m + nadp_m --> pyr_m + co2_m + nadph_m h_e + melib_e --> h_c + melib_c melt_c + h2o_c <=> sbt_D_c + gal_c atp_c + h2o_c + met_L_c --> pi_c + ppi_c + amet_c achms_c + cys_L_c --> ac_c + h_c + cyst_L_c 5mthf_c + hcys_L_c --> h_c + thf_c + met_L_c atp_c + met_L_c + trnamet_c --> amp_c + ppi_c + mettrna_c atp_m + trnamet_m + met_L_m --> mettrna_m + amp_m + ppi_m h_m + met_L_m <=> h_c + met_L_c h_e + met_L_e <=> h_c + met_L_c atp_c + mev_R_c --> h_c + adp_c + 5pmev_c mev_R_c + ctp_c --> h_c + cdp_c + 5pmev_c gtp_c + mev_R_c --> h_c + gdp_c + 5pmev_c mev_R_c + utp_c --> h_c + udp_c + 5pmev_c 0.01 ptdmeeta_SC_c + amet_c --> 0.01 ptd2meeta_SC_c + h_c + ahcys_c dhap_c --> pi_c + mthgxl_c mhpglu_c + hcys_L_c --> met_L_c + hpglu_c atp_n + mi13456p_n --> minohp_n + h_n + adp_n mi1345p_n + atp_n --> mi13456p_n + adp_n + h_n mi1456p_n + atp_n --> mi13456p_n + h_n + adp_n atp_n + mi145p_n --> adp_n + h_n + mi1456p_n atp_n + mi145p_n --> mi1345p_n + adp_n + h_n mi145p_c <=> mi145p_n mi1p_D_c + h2o_c --> pi_c + inost_c g6p_c --> mi1p_D_c minohp_c <=> minohp_n h2o_c + 0.01 mip2c124_SC_c --> h_c + cer1_24_c + man2mi1p_D_c h2o_c + 0.01 mip2c126_SC_c --> h_c + cer1_26_c + man2mi1p_D_c h2o_c + 0.01 mip2c224_SC_c --> h_c + cer2_24_c + man2mi1p_D_c 0.01 mip2c226_SC_c + h2o_c --> h_c + cer2_26_c + man2mi1p_D_c h2o_c + 0.01 mip2c324_SC_c --> h_c + cer3_24_c + man2mi1p_D_c h2o_c + 0.01 mip2c326_SC_c --> h_c + man2mi1p_D_c + cer3_26_c 0.01 mipc124_SC_c + 0.01 ptd1ino_SC_c --> 0.01 12dgr_SC_c + 0.01 mip2c124_SC_c 0.01 ptd1ino_SC_c + 0.01 mipc126_SC_c --> 0.01 12dgr_SC_c + 0.01 mip2c126_SC_c 0.01 mipc224_SC_c + 0.01 ptd1ino_SC_c --> 0.01 12dgr_SC_c + 0.01 mip2c224_SC_c 0.01 ptd1ino_SC_c + 0.01 mipc226_SC_c --> 0.01 12dgr_SC_c + 0.01 mip2c226_SC_c 0.01 mipc324_SC_c + 0.01 ptd1ino_SC_c --> 0.01 12dgr_SC_c + 0.01 mip2c324_SC_c 0.01 mipc326_SC_c + 0.01 ptd1ino_SC_c --> 0.01 12dgr_SC_c + 0.01 mip2c326_SC_c h2o_c + 0.01 mipc124_SC_c --> h_c + cer1_24_c + manmi1p_D_c h2o_c + 0.01 mipc126_SC_c --> h_c + cer1_26_c + manmi1p_D_c h2o_c + 0.01 mipc224_SC_c --> h_c + cer2_24_c + manmi1p_D_c 0.01 mipc226_SC_c + h2o_c --> h_c + cer2_26_c + manmi1p_D_c h2o_c + 0.01 mipc324_SC_c --> h_c + cer3_24_c + manmi1p_D_c h2o_c + 0.01 mipc326_SC_c --> h_c + manmi1p_D_c + cer3_26_c gdpmann_c + 0.01 ipc124_SC_c --> h_c + gdp_c + 0.01 mipc124_SC_c 0.01 ipc126_SC_c + gdpmann_c --> h_c + gdp_c + 0.01 mipc126_SC_c 0.01 ipc224_SC_c + gdpmann_c --> h_c + 0.01 mipc224_SC_c + gdp_c gdpmann_c + 0.01 ipc226_SC_c --> h_c + gdp_c + 0.01 mipc226_SC_c 0.01 ipc324_SC_c + gdpmann_c --> h_c + 0.01 mipc324_SC_c + gdp_c gdpmann_c + 0.01 ipc326_SC_c --> h_c + 0.01 mipc326_SC_c + gdp_c mmet_e + h_e --> h_c + mmet_c mlthf_c + 3mob_c + h2o_c --> thf_c + 2dhp_c 5mta_c + pi_c --> ade_c + 5mdr1p_c methf_c + h2o_c <=> h_c + 10fthf_c methf_m + h2o_m <=> h_m + 10fthf_m mlthf_c + nadp_c <=> nadph_c + methf_c mlthf_c + nad_c --> methf_c + nadh_c nadp_m + mlthf_m <=> methf_m + nadph_m mlthf_c + nadph_c + 2.0 h_c --> 5mthf_c + nadp_c 5mdr1p_c <=> 5mdru1p_c h2o_c + n4abutn_c + nad_c --> 2.0 h_c + 4aabutn_c + nadh_c nac_e <=> nac_c h2o_x + nad_x --> 2.0 h_x + nmn_x + amp_x h_c + q6_m + nadh_c --> q6h2_m + nad_c q6_m + nadh_m + h_m --> nad_m + q6h2_m atp_c + nad_c --> h_c + adp_c + nadp_c nad_m + atp_m --> nadp_m + adp_m + h_m h2o_c + nad_c --> h_c + ncam_c + adprib_c h2o_m + nad_m --> adprib_m + h_m + ncam_m h2o_c + nadp_c --> pi_c + nad_c h2o_m + nadp_m --> pi_m + nad_m nadp_c <=> nadp_e atp_c + nh4_c + dnad_c --> h_c + amp_c + ppi_c + nad_c nh4_n + dnad_n + atp_n --> ppi_n + nad_n + h_n + amp_n nad_n <=> nad_c h_c + nac_c + prpp_c --> nicrnt_c + ppi_c prpp_m + nac_m + h_m --> nicrnt_m + ppi_m h_e + na1_c <=> h_c + na1_e adp_c + h2o_c --> amp_c + h_c + pi_c h2o_c + gdp_c --> h_c + gmp_c + pi_c h2o_g + gdp_g --> gmp_g + pi_g + h_g h2o_c + dgdp_c --> h_c + dgmp_c + pi_c udp_c + h2o_c --> ump_c + h_c + pi_c atp_c + gdp_c <=> gtp_c + adp_c atp_c + udp_c <=> adp_c + utp_c atp_c + cdp_c <=> adp_c + ctp_c atp_c + dtdp_c <=> dttp_c + adp_c atp_c + dgdp_c <=> adp_c + dgtp_c atp_c + dudp_c <=> adp_c + dutp_c atp_c + dcdp_c <=> adp_c + dctp_c atp_c + dadp_c <=> adp_c + datp_c atp_c + idp_c <=> itp_c + adp_c Nbfortyr_c --> Nbfortyr_e h_c + nadph_c + 2.0 Nfortyr_c --> nadp_c + Nbfortyr_c nh4_e <=> nh4_c nh4_c --> nh4_e nh4_c <=> nh4_m nh4_c <=> nh4_n nh4_c <=> nh4_x h_c + atp_c + nmn_c --> ppi_c + nad_c h_m + atp_m + nmn_m --> nad_m + ppi_m nmn_e + h_e --> h_c + nmn_c h_c + nmn_c <=> h_m + nmn_m h_c + nmn_c <=> h_x + nmn_x ncam_c + h2o_c <=> nac_c + nh4_c h2o_m + ncam_m <=> nac_m + nh4_m h_c + nicrnt_c + atp_c --> ppi_c + dnad_c nicrnt_m + h_m + atp_m --> dnad_m + ppi_m 2.0 h_c + prpp_c + quln_c --> co2_c + nicrnt_c + ppi_c 2.0 h_m + prpp_m + quln_m --> nicrnt_m + co2_m + ppi_m ncam_c + amet_c --> 1mncam_c + ahcys_c h2o_c + dump_c --> pi_c + duri_c h2o_c + xmp_c --> xtsn_c + pi_c h2o_c + imp_c --> ins_c + pi_c ump_c + h2o_c --> uri_c + pi_c h2o_c + dcmp_c --> dcyt_c + pi_c h2o_c + cmp_c --> cytd_c + pi_c h2o_c + dtmp_c --> pi_c + thymd_c damp_c + h2o_c --> pi_c + dad_2_c amp_c + h2o_c --> adn_c + pi_c h2o_c + dgmp_c --> dgsn_c + pi_c gmp_c + h2o_c --> gsn_c + pi_c gtp_c + h2o_c --> h_c + gdp_c + pi_c h2o_c + dgtp_c --> h_c + dgdp_c + pi_c 2.0 h2o_c + ind3acnl_c --> ind3ac_c + nh4_c 2.0 h2o_c + aprop_c --> nh4_c + ala_L_c 2.0 h2o_c + acybut_c --> glu_L_c + nh4_c o2_e <=> o2_c o2_c <=> o2_r o2_c <=> o2_m oaa_c <=> oaa_e h_c + oaa_c <=> h_m + oaa_m nad_m + 2obut_m + coa_m --> nadh_m + ppcoa_m + co2_m cbp_c + orn_c --> h_c + pi_c + citr_L_c ocdca_e --> ocdca_c ocdcea_e --> ocdcea_c ocdcya_e --> ocdcya_c accoa_c + etoh_c --> coa_c + aces_c iamoh_c + accoa_c --> iamac_c + coa_c accoa_c + 2mbtoh_c --> coa_c + 2mbac_c ibutoh_c + accoa_c --> ibutac_c + coa_c accoa_c + 2phetoh_c --> coa_c + pheac_c glu_L_c + ohpb_c <=> akg_c + phthr_c 3c4mop_c + h_c --> 4mop_c + co2_c 3c4mop_m + h_m --> 4mop_m + co2_m orot5p_c + h_c --> ump_c + co2_c h_c + orn_c --> co2_c + ptrc_c orn_c + akg_c --> glu_L_c + glu5sa_c glu_L_m + acorn_m --> acglu_m + orn_m h_e + orn_e <=> h_c + orn_c h_c + orn_m <=> orn_c + h_m ppi_c + orot5p_c <=> prpp_c + orot_c h_m + oxag_m <=> co2_m + 2oxoadp_m oxag_c + akg_m <=> akg_c + oxag_m nad_m + 1pyr5c_m + 2.0 h2o_m --> nadh_m + glu_L_m + h_m 2.0 h_c + 1pyr5c_c + nadph_c --> nadp_c + pro_L_c pacald_c <=> pacald_e pacald_c <=> pacald_m atp_c + 0.01 pa_SC_c --> adp_c + 0.01 dagpy_SC_c pan4p_c <=> pan4p_m atp_c + ala_B_c + pant_R_c --> h_c + amp_c + pnto_R_c + ppi_c pant_R_c <=> pant_R_m paps_c + trdrd_c --> 2.0 h_c + pap_c + so3_c + trdox_c pap_e <=> pap_c pap_c <=> pap_m pa_SC_c <=> pa_SC_m atp_c + pyr_c + hco3_c --> adp_c + pi_c + h_c + oaa_c 12dgr_SC_c + pc_SC_c --> triglyc_SC_c + 1agpc_SC_c h2o_c + camp_c --> h_c + amp_c 35cdamp_c + h2o_c --> damp_c + h_c h2o_c + 35cimp_c --> h_c + imp_c h2o_c + 35cgmp_c --> h_c + gmp_c h2o_c + 35ccmp_c --> h_c + cmp_c dhlam_m + nad_m --> lpam_m + nadh_m + h_m nad_m + pyr_m + coa_m --> nadh_m + accoa_m + co2_m o2_c + pdx5p_c <=> h2o2_c + pydx5p_c pendp_c <=> pendp_m accoa_c + pepd_c --> h_c + apep_c + coa_c h_e + pepd_e --> h_c + pepd_c h_c + ethamp_c + ctp_c --> cdpea_c + ppi_c 0.01 pe_SC_c + amet_c --> h_c + 0.01 ptdmeeta_SC_c + ahcys_c pe_SC_c <=> pe_SC_g pe_SC_c <=> pe_SC_m pe_SC_c <=> pe_SC_v atp_c + f6p_c --> h_c + fdp_c + adp_c atp_c + f6p_c --> h_c + adp_c + f26bp_c atp_c + tag6p_D_c --> h_c + tagdp_D_c + adp_c s7p_c + atp_c --> h_c + adp_c + s17bp_c gam1p_c <=> gam6p_c 3pg_c + nad_c --> h_c + nadh_c + 3php_c g6p_c <=> f6p_c atp_c + 3pg_c <=> adp_c + 13dpg_c h2o_c + 6pgl_c --> h_c + 6pgc_c 2pg_c <=> 3pg_c g1p_c <=> g6p_c h2o_m + 0.01 pgp_SC_m --> pi_m + 0.01 pg_SC_m nad_m + 2.0 h2o_m + 1p3h5c_m --> nadh_m + e4hglu_m + h_m h_m + 1p3h5c_m + h2o_m <=> 4hglusa_m pheac_c --> pheac_e akg_c + phe_L_c <=> glu_L_c + phpyr_c atp_c + trnaphe_c + phe_L_c --> phetrna_c + amp_c + ppi_c trnaphe_m + phe_L_m + atp_m --> phetrna_m + amp_m + ppi_m h_m + phe_L_m <=> h_c + phe_L_c phe_L_e + h_e <=> h_c + phe_L_c h2o_c + 0.01 ptd135bp_SC_c --> 0.01 ptd3ino_SC_c + pi_c atp_c + 0.01 ptd3ino_SC_c --> h_c + adp_c + 0.01 ptd134bp_SC_c atp_c + 0.01 ptd3ino_SC_c --> h_c + adp_c + 0.01 ptd135bp_SC_c h2o_c + 0.01 ptd145bp_SC_c --> pi_c + 0.01 ptd4ino_SC_c 0.01 ptd145bp_SC_c + h2o_c --> 0.01 12dgr_SC_c + h_c + mi145p_c atp_c + 0.01 ptd4ino_SC_c --> h_c + 0.01 ptd145bp_SC_c + adp_c atp_c + 0.01 ptd1ino_SC_c --> h_c + adp_c + 0.01 ptd3ino_SC_c atp_c + 0.01 ptd1ino_SC_c --> h_c + adp_c + 0.01 ptd4ino_SC_c atp_n + 0.01 ptd1ino_SC_n --> 0.01 ptd4ino_SC_n + adp_n + h_n 0.01 cdpdag_SC_c + inost_c --> h_c + cmp_c + 0.01 ptd1ino_SC_c h_c + pi_c <=> pi_m + h_m h_c + pi_c <=> pi_n + h_n h_c + pi_c <=> h_x + pi_x pi_e + h_e <=> h_c + pi_c h_c + pi_c <=> pi_v + h_v oh1_m + pi_c <=> pi_m + oh1_c h2o_e + 0.005 ptd1ino_SC_e --> 0.27 hdca_e + 0.05 ocdca_e + 0.02 dca_e + 0.17 hdcea_e + h_e + 0.24 ocdcea_e + 0.1 ttdca_e + 0.09 ocdcya_e + 0.06 ddca_e + 0.5 g3pi_e h2o_c + 0.005 pc_SC_c --> h_c + 0.1 ttdca_c + 0.17 hdcea_c + 0.02 dca_c + 0.24 ocdcea_c + 0.5 g3pc_c + 0.09 ocdcya_c + 0.06 ddca_c + 0.27 hdca_c + 0.05 ocdca_c 0.005 pc_SC_e + h2o_e --> 0.27 hdca_e + 0.05 ocdca_e + h_e + 0.02 dca_e + 0.17 hdcea_e + 0.1 ttdca_e + 0.24 ocdcea_e + 0.5 g3pc_e + 0.09 ocdcya_e + 0.06 ddca_e 0.01 pc_SC_c + h2o_c --> h_c + 0.01 pa_SC_c + chol_c man1p_c <=> man6p_c h2o_c + 5aprbu_c --> pi_c + 4r5au_c 0.01 ptd2meeta_SC_c + amet_c --> h_c + 0.01 pc_SC_c + ahcys_c atp_c + 5pmev_c --> adp_c + 5dpmev_c ppmi12346p_c + h2o_c --> h_c + minohp_c + pi_c atp_c + minohp_c --> ppmi12346p_c + adp_c h2o_c + ppmi1346p_c --> h_c + mi13456p_c + pi_c atp_c + mi13456p_c --> adp_c + ppmi1346p_c 4ampm_c + atp_c --> adp_c + 2mahmp_c rnam_c + pi_c <=> h_c + ncam_c + r1p_c pnto_R_c + atp_c --> h_c + adp_c + 4ppan_c h_e + pnto_R_e <=> h_c + pnto_R_c h2o_c + N1aspmd_c + o2_c --> h2o2_c + aproa_c + aprut_c h2o_c + N1sprm_c + o2_c --> h2o2_c + aproa_c + N1aspmd_c h2o_c + o2_c + sprm_c --> h2o2_c + aproa_c + spmd_c h2o_c + ppi_c --> h_c + 2.0 pi_c h2o_m + ppi_m --> 2.0 pi_m + h_m 2.0 5aop_c --> ppbng_c + h_c + 2.0 h2o_c h_c + 4ppcys_c --> co2_c + pan4p_c atp_c + oaa_c --> co2_c + pep_c + adp_c r1p_c <=> r5p_c 4ppan_c + ctp_c + cys_L_c --> h_c + ppi_c + cmp_c + 4ppcys_c nad_c + pphn_c --> co2_c + 34hpp_c + nadh_c nadp_c + pphn_c --> co2_c + nadph_c + 34hpp_c h_c + pphn_c --> co2_c + h2o_c + phpyr_c pppg9_c <=> pppg9_m 3.0 o2_m + 2.0 pppg9_m --> 6.0 h2o_m + 2.0 ppp9_m ipdp_m + pendp_m --> hexdp_m + ppi_m h_c + phpyr_c --> co2_c + pacald_c atp_c + pram_c + gly_c <=> adp_c + gar_c + pi_c + h_c atp_c + fpram_c --> adp_c + pi_c + 2.0 h_c + air_c pran_c --> 2cpr5p_c h2o_c + prbamp_c --> prfp_c atp_c + 5aizc_c + asp_L_c <=> adp_c + 25aics_c + pi_c + h_c h2o_c + prbatp_c --> h_c + ppi_c + prbamp_c atp_c + h2o_c + fgam_c + gln_L_c --> adp_c + pi_c + h_c + glu_L_c + fpram_c prfp_c --> prlp_c nad_m + pro_L_m --> nadh_m + 1pyr5c_m + 2.0 h_m atp_c + trnapro_c + pro_L_c --> amp_c + protrna_c + ppi_c pro_L_e + h_e <=> h_c + pro_L_c pro_L_c <=> pro_L_m atp_c + r5p_c <=> amp_c + h_c + prpp_c prpp_c <=> prpp_m skm5p_c + pep_c --> 3psme_c + pi_c 0.01 ps_SC_g + h_g --> co2_g + 0.01 pe_SC_g h_m + 0.01 ps_SC_m --> 0.01 pe_SC_m + co2_m 0.01 ps_SC_v + h_v --> co2_v + 0.01 pe_SC_v 0.01 cdpdag_SC_c + ser_L_c <=> h_c + 0.01 ps_SC_c + cmp_c 0.01 cdpdag_SC_m + ser_L_m <=> h_m + cmp_m + 0.01 ps_SC_m glu_L_c + 3php_c --> akg_c + pser_L_c psph1p_c --> psph1p_r psph1p_c --> 2hhxdal_c + ethamp_c nadph_c + h_c + sphgn_c + o2_c --> h2o_c + psphings_c + nadp_c pser_L_c + h2o_c --> ser_L_c + pi_c ps_SC_c <=> ps_SC_g ps_SC_c <=> ps_SC_m ps_SC_c <=> ps_SC_v ptd1ino_SC_c <=> ptd1ino_SC_n ptd4ino_SC_c <=> ptd4ino_SC_n h2o_x + dcacoa_x --> coa_x + h_x + dca_x h2o_x + ddcacoa_x --> h_x + coa_x + ddca_x h2o_x + ttccoa_x --> coa_x + ttc_x + h_x h2o_x + pmtcoa_x --> h_x + hdca_x + coa_x h2o_x + tdcoa_x --> ttdca_x + coa_x + h_x h2o_x + stcoa_x --> coa_x + h_x + ocdca_x occoa_x + h2o_x --> coa_x + octa_x + h_x h_c + atp_c + pan4p_c --> ppi_c + dpcoa_c pan4p_m + h_m + atp_m --> dpcoa_m + ppi_m h_c + ptrc_e --> ptrc_c + h_e ptrc_c --> ptrc_e adn_c + pi_c <=> ade_c + r1p_c pi_m + adn_m <=> r1p_m + ade_m pi_c + dad_2_c <=> 2dr1p_c + ade_c pi_c + gsn_c <=> gua_c + r1p_c pi_m + gsn_m <=> r1p_m + gua_m dgsn_c + pi_c <=> gua_c + 2dr1p_c ins_c + pi_c <=> hxan_c + r1p_c pi_c + din_c <=> 2dr1p_c + hxan_c xtsn_c + pi_c <=> r1p_c + xan_c h2o_c + pyam5p_c + o2_c --> h2o2_c + nh4_c + pydx5p_c atp_c + pydam_c --> h_c + adp_c + pyam5p_c atp_c + pydx_c --> h_c + adp_c + pydx5p_c atp_c + pydxn_c --> h_c + adp_c + pdx5p_c o2_c + pydxn_c <=> pydx_c + h2o2_c 2.0 h2o_c + pydx_c + 0.5 o2_c + nh4_c <=> pydam_c + 2.0 h2o2_c h_c + pep_c + adp_c --> atp_c + pyr_c uri_c + pi_c <=> r1p_c + ura_c nadp_m + glu5sa_m + h2o_m --> 2.0 h_m + glu_L_m + nadph_m h_c + pyr_c --> acald_c + co2_c h_c + acald_c + pyr_c --> actn_R_c + co2_c pyr_c --> pyr_e h_e + pyr_e --> h_c + pyr_c h_c + pyr_c <=> pyr_m + h_m h_c + pyr_c <=> h_x + pyr_x cmusa_c --> h_c + h2o_c + quln_c dhap_c + iasp_c --> 2.0 h2o_c + pi_c + quln_c quln_c <=> quln_m raffin_c + h2o_c --> sucr_c + gal_c atp_c + ribflv_c --> h_c + fmn_c + adp_c ribflv_m + atp_m --> fmn_m + adp_m + h_m db4p_c + 4r5au_c --> dmlz_c + 2.0 h2o_c + pi_c 2.0 dmlz_c --> ribflv_c + 4r5au_c atp_c + rib_D_c --> h_c + adp_c + r5p_c h_e + ribflv_e --> h_c + ribflv_c ribflv_c <=> ribflv_m h_e + rib_D_e --> h_c + rib_D_c adp_c + trdrd_c --> h2o_c + dadp_c + trdox_c adp_n + trdrd_n --> dadp_n + h2o_n + trdox_n gdp_c + trdrd_c --> h2o_c + dgdp_c + trdox_c trdrd_n + gdp_n --> h2o_n + trdox_n + dgdp_n trdrd_c + cdp_c --> h2o_c + trdox_c + dcdp_c cdp_n + trdrd_n --> dcdp_n + trdox_n + h2o_n udp_c + trdrd_c --> h2o_c + trdox_c + dudp_c trdrd_n + udp_n --> dudp_n + h2o_n + trdox_n atp_c + rnam_c --> h_c + nmn_c + adp_c atp_c + trdrd_c --> h2o_c + datp_c + trdox_c trdrd_c + gtp_c --> h2o_c + dgtp_c + trdox_c trdrd_c + ctp_c --> h2o_c + trdox_c + dctp_c trdrd_c + utp_c --> h2o_c + dutp_c + trdox_c ru5p_D_c <=> xu5p_D_c r5p_c <=> ru5p_D_c L2aadp6sa_c + nadph_c + h_c + glu_L_c <=> h2o_c + saccrp_L_c + nadp_c h2o_c + saccrp_L_c + nad_c <=> akg_c + h_c + lys_L_c + nadh_c h_c + atp_c + so4_c --> ppi_c + aps_c zymst_c + amet_c --> fecost_c + h_c + ahcys_c sph1p_r + h2o_r --> sphgn_r + pi_r psph1p_r + h2o_r --> psphings_r + pi_r sbt_D_c + nad_c --> h_c + fru_c + nadh_c sbt_L_c + nad_c --> h_c + nadh_c + srb_L_c h_c + glc_D_c + nadph_c --> nadp_c + sbt_D_c sbt_D_e <=> sbt_D_c sbt_L_e <=> sbt_L_c accoa_c + ser_L_c --> coa_c + acser_c ser_L_c --> pyr_c + nh4_c pmtcoa_c + h_c + ser_L_c --> co2_c + coa_c + 3dsphgn_c atp_c + trnaser_c + ser_L_c --> amp_c + sertrna_c + ppi_c h_c + ser_L_c <=> h_m + ser_L_m h_e + ser_L_e <=> h_c + ser_L_c h2o_c + Sfglutth_c <=> h_c + for_c + gthrd_c dscl_c + nadp_c --> h_c + scl_c + nadph_c scl_c + fe2_c --> 3.0 h_c + sheme_c h_c + nadph_c + 3dhsk_c --> skm_c + nadp_c skm_c + atp_c --> h_c + skm5p_c + adp_c suchms_c + cys_L_c --> h_c + succ_c + cyst_L_c h2o_c + suchms_c <=> 2obut_c + nh4_c + h_c + succ_c atp_c + sphgn_c --> h_c + adp_c + sph1p_c atp_c + psphings_c --> h_c + adp_c + psph1p_c h_c + adp_c + so4_c <=> pi_c + aps_c so3_c --> so3_e so4_e --> so4_c sph1p_c --> sph1p_r sph1p_c --> ethamp_c + hxdcal_c spmd_c + accoa_c --> h_c + coa_c + N1aspmd_c h_c + spmd_e --> spmd_c + h_e spmd_c --> spmd_e ametam_c + ptrc_c --> spmd_c + 5mta_c + h_c spmd_c + ametam_c --> 5mta_c + h_c + sprm_c h_c + sprm_e --> h_e + sprm_c Ssq23epx_r <=> Ssq23epx_c h_r + sql_r + o2_r + nadph_r --> Ssq23epx_r + h2o_r + nadp_r o2_r + nadh_r + h_r + sql_r --> Ssq23epx_r + h2o_r + nad_r nadph_c + 2.0 frdp_c + h_c --> sql_c + 2.0 ppi_c + nadp_c sql_c <=> sql_r srb_L_e <=> srb_L_c h2o_c + sucsal_c + nadp_c --> nadph_c + 2.0 h_c + succ_c h_e + succ_e <=> h_c + succ_c pi_m + succ_c --> succ_m + pi_c fad_m + succ_m <=> fum_m + fadh2_m q6_m + succ_m <=> fum_m + q6h2_m q6_m + fadh2_m <=> fad_m + q6h2_m fum_m + succ_c --> succ_m + fum_c succ_m + atp_m + coa_m <=> pi_m + succoa_m + adp_m sucr_e + h2o_e --> glc_D_e + fru_e sucr_e + h_e --> h_c + sucr_c 3.0 h2o_c + 3.0 nadp_c + h2s_c <=> 3.0 nadph_c + 5.0 h_c + so3_c 34hpl_m --> h2o_m + T4hcinnm_m h2o_c + 0.01 triglyc_SC_c --> 0.01 12dgr_SC_c + 0.02 dca_c + 0.1 ttdca_c + 0.17 hdcea_c + 0.24 ocdcea_c + h_c + 0.09 ocdcya_c + 0.06 ddca_c + 0.27 hdca_c + 0.05 ocdca_c g3p_c + s7p_c <=> e4p_c + f6p_c akg_c + taur_c + o2_c --> co2_c + h_c + so3_c + succ_c + aacald_c taur_c <=> taur_e tchola_c + h2o_v + atp_v --> adp_v + tchola_v + pi_v + h_v methf_m + h2o_m --> h_m + 5fthf_m atp_c + thf_c + glu_L_c <=> h_c + adp_c + pi_c + thfglu_c h2o2_c + trdrd_c --> 2.0 h2o_c + trdox_c h2o2_m + trdrd_m <=> trdox_m + 2.0 h2o_m h2o2_n + trdrd_n --> trdox_n + 2.0 h2o_n h2o2_x + trdrd_x <=> trdox_x + 2.0 h2o_x thmpp_e + 2.0 h2o_e --> 2.0 pi_e + h_e + thm_e thymd_e + h_e --> h_c + thymd_c h2o_c + thmmp_c --> thm_c + pi_c thmpp_c --> thmpp_m h2o_e + thmmp_e --> pi_e + thm_e h_e + thm_e --> h_c + thm_c athr_L_c --> acald_c + gly_c thr_L_c --> acald_c + gly_c thr_L_c --> 2obut_c + nh4_c thr_L_m --> 2obut_m + nh4_m h2o_c + phom_c --> pi_c + thr_L_c atp_c + trnathr_c + thr_L_c --> amp_c + thrtrna_c + ppi_c thr_L_m + atp_m + trnathr_m --> ppi_m + thrtrna_m + amp_m h_c + thr_L_c <=> h_m + thr_L_m thr_L_e + h_e <=> h_c + thr_L_c thym_c + h_e <=> h_c + thym_e h_c + xu5p_D_c + cys_L_c + gly_c + achms_c --> 4abut_c + nh4_c + 3.0 h2o_c + pyr_c + 4mpetz_c + co2_c + ac_c h_c + r5p_c + cys_L_c + achms_c + gly_c --> 4abut_c + 3.0 h2o_c + pyr_c + 4mpetz_c + nh4_c + co2_c + ac_c r5p_c + xu5p_D_c <=> g3p_c + s7p_c e4p_c + xu5p_D_c <=> g3p_c + f6p_c atp_c + thymd_c --> h_c + adp_c + dtmp_c thm_c + atp_c --> amp_c + h_c + thmpp_c pi_c + thymd_c <=> thym_c + 2dr1p_c thmpp_c + atp_c --> adp_c + thmtp_c mlthf_c + dump_c --> dhf_c + dtmp_c h2o_c + thm_c --> h_c + 4ahmmp_c + 4mhetz_c atp_c + thmmp_c <=> thmpp_c + adp_c h_c + 2mahmp_c + 4mpetz_c --> ppi_c + thmmp_c dhap_c <=> g3p_c trdox_c <=> trdox_x h_c + nadph_c + trdox_c --> trdrd_c + nadp_c trdrd_c <=> trdrd_x trdox_m + h_m + nadph_m --> nadp_m + trdrd_m h2o_c + tre6p_c --> tre_c + pi_c g6p_c + udpg_c --> h_c + tre6p_c + udp_c h2o_c + tre_c --> 2.0 glc_D_c tre_v + h2o_v --> 2.0 glc_D_v tre_e + h_e --> h_c + tre_c h_c + tre_c <=> tre_v + h_v 0.01 12dgr_SC_c + 0.17 hdcoa_c + 0.27 pmtcoa_c + 0.06 ddcacoa_c + 0.24 odecoa_c + 0.05 stcoa_c + 0.02 dcacoa_c + 0.09 ocdycacoa_c + 0.1 tdcoa_c --> 0.01 triglyc_SC_c + coa_c o2_c + trp_L_c --> Lfmkynr_c 3ig3p_c + ser_L_c --> g3p_c + h2o_c + trp_L_c akg_c + trp_L_c <=> indpyr_c + glu_L_c atp_c + trp_L_c + trnatrp_c --> trptrna_c + amp_c + ppi_c trnatrp_m + atp_m + trp_L_m --> trptrna_m + amp_m + ppi_m h_c + trp_L_c <=> h_m + trp_L_m trp_L_e + h_e <=> h_c + trp_L_c ttccoa_c <=> ttccoa_x ttdca_e <=> ttdca_c 10fthf_c + tyr_L_c --> h_c + thf_c + Nfortyr_c 34hpp_c + glu_L_c --> akg_c + tyr_L_c glu_L_m + 34hpp_m --> tyr_L_m + akg_m glu_L_x + 34hpp_x --> tyr_L_x + akg_x atp_c + trnatyr_c + tyr_L_c --> amp_c + ppi_c + tyrtrna_c tyr_L_m + atp_m + trnatyr_m --> tyrtrna_m + amp_m + ppi_m h_c + tyr_L_c <=> h_m + tyr_L_m h_c + tyr_L_c <=> tyr_L_x + h_x h_e + tyr_L_e <=> h_c + tyr_L_c tyr_L_c + h_v --> h_c + tyr_L_v tyr_L_v + h_v --> h_c + tyr_L_c h_c + acgam1p_c + utp_c <=> ppi_c + udpacgal_c udpg_c <=> udpgal_c udpgal_c --> udpgal_g gal1p_c + udpg_c <=> g1p_c + udpgal_c h2o_c + 2.0 h_c + urdglyc_c <=> co2_c + 2.0 nh4_c + glx_c ump_c + atp_c <=> adp_c + udp_c ump_n + atp_n <=> adp_n + udp_n ump_c <=> ump_n glu_L_c + 2kmb_c --> akg_c + met_L_c uppg3_c + 2.0 amet_c --> h_c + dscl_c + 2.0 ahcys_c hmbil_c --> uppg3_c + h2o_c 4.0 h_c + uppg3_c --> 4.0 co2_c + cpppg3_c prpp_c + ura_c --> ump_c + ppi_c ura_e + h_e --> h_c + ura_c 2.0 h_e + urea_e <=> 2.0 h_c + urea_c atp_c + urea_c + hco3_c <=> adp_c + allphn_c + pi_c + h_c atp_c + dump_c <=> adp_c + dudp_c dump_n + atp_n <=> dudp_n + adp_n uri_c + atp_c --> ump_c + h_c + adp_c gtp_c + uri_c --> ump_c + gdp_c + h_c h_e + uri_e --> h_c + uri_c 2.0 h2o_c + utp_c --> ump_c + 2.0 h_c + 2.0 pi_c 2.0 h_c + ump_m + utp_c --> 2.0 h_m + ump_c + utp_m akg_c + val_L_c <=> glu_L_c + 3mob_c val_L_m + akg_m --> 3mob_m + glu_L_m atp_c + val_L_c + trnaval_c --> valtrna_c + amp_c + ppi_c trnaval_m + atp_m + val_L_m --> valtrna_m + amp_m + ppi_m h_c + val_L_c <=> h_m + val_L_m val_L_e + h_e <=> h_c + val_L_c xan_e <=> xan_c xan_c + prpp_c --> ppi_c + xmp_c xtsn_e + h_e --> h_c + xtsn_c atp_c + xylu_D_c --> h_c + adp_c + xu5p_D_c h_c + xyl_D_c + nadph_c --> nadp_c + xylt_c xylt_c + nad_c --> h_c + xylu_D_c + nadh_c xylt_e <=> xylt_c xyl_D_e <=> xyl_D_c ura_c + r5p_c <=> h2o_c + psd5p_c 0.01 hexccoa_c + 0.02 pmtcoa_c + 0.03 stcoa_c + 0.655 hdcoa_c + 0.27 odecoa_c + 0.01 zymst_c + 0.015 tdcoa_c --> 0.01 zymstest_SC_c + coa_c 0.01 zymstest_SC_c + h2o_c --> 0.27 ocdcea_c + 0.01 zymst_c + h_c + 0.015 ttdca_c + 0.01 hexc_c + 0.655 hdcea_c + 0.02 hdca_c + 0.03 ocdca_c 0.01 zymstest_SC_e + h2o_e --> 0.02 hdca_e + 0.03 ocdca_e + 0.01 hexc_e + 0.655 hdcea_e + h_e + 0.01 zymst_e + 0.015 ttdca_e + 0.27 ocdcea_e zymst_e <=> zymst_c 0.00099 ribflv_c + 0.0036 dtmp_c + 0.8079 mannan_c + 0.0663 his_L_c + 59.276 atp_c + 0.1927 ile_L_c + 1.1348 13BDglcn_c + 0.02 so4_c + 0.1054 gln_L_c + 0.0066 cys_L_c + 0.102 tyr_L_c + 0.5185 glycogen_c + 6e-05 pc_SC_c + 0.0447 cmp_c + 0.2964 leu_L_c + 0.0024 dgmp_c + 0.0599 ump_c + 4.5e-05 pe_SC_c + 0.1914 thr_L_c + 0.0015 zymst_c + 0.3018 glu_L_c + 5.3e-05 ptd1ino_SC_c + 0.1607 arg_L_c + 0.0507 met_L_c + 0.4588 ala_L_c + 0.046 amp_c + 59.276 h2o_c + 0.0036 damp_c + 0.1854 ser_L_c + 0.1017 asn_L_c + 0.2862 lys_L_c + 0.0234 tre_c + 0.1339 phe_L_c + 6e-06 pa_SC_c + 0.0284 trp_L_c + 6.6e-05 triglyc_SC_c + 0.2904 gly_c + 0.2975 asp_L_c + 0.1647 pro_L_c + 0.046 gmp_c + 0.2646 val_L_c + 0.0007 ergst_c + 1.7e-05 ps_SC_c + 0.0024 dcmp_c --> 59.276 adp_c + 59.305 pi_c + 58.70001 h_c

Models in Minho database have been manually verified if they can be used to run simulations as described in the publications.

models.minho.validated.VvuMBEL943 # use TAB completion to see the other models

Name	HyunUkKim2010_VvuMBEL943_MetabolicModeling
Number of metabolites	912
Number of reactions	1019
Reactions	GLN + 2.0 ATP + CO2 --> CAP + 2.0 ADP + GLU + PI GLU --> CO2 + GABA NADPH + GLN + AKG --> NADP + 2.0 GLU UDP + NADMA <=> UDPNADMA ATP + GLU + NH3 --> GLN + ADP + PI PI + NANEU9P <=> NADMA6P + PEP URI + PI <=> R1P + URA NAGA6P <=> NADMA6P DCMP --> DUMP + NH3 ATP + NADMA --> NADMA6P + ADP CYTD --> URI + NH3 PI + NADMA <=> NADMA6P DC --> NH3 + DU CT --> URA + NH3 a_5MC <=> TM + NH3 NANEU <=> PYR + NADMA NANEU + PI <=> PEP + NADMA UDPNAG <=> UDPNADMA 2.0 NAD + UDPNADMA --> 2.0 NADH + UDPNADMAU UDPNAG <=> UDP + NADMA PYR + ATP --> PEP + PI + AMP DTDPGLU <=> DTDPGLAC PI + ACCOA <=> COA + ACETYLP HSERxt --> HSERxt_b NADH + PYR <=> NAD + LAC SLACxt --> SLACxt_b NANEU + CTP <=> CMPNANEU + PPI NGNEU + CTP <=> CMPNGNEU + PPI 2.0 NAD + UDPGAL --> 2.0 NADH + UDPDGALAC 2.0 NADP + DTDPGLU --> 2.0 NADPH + DTDPDGLUC UDPNAG + PEP --> UDPNAGEP + PI NADPH + UDPNAGEP --> NADP + UDPNAM CYTD + DTTP --> DTDP + CMP DGTP + URI --> DGDP + UMP DGTP + CYTD --> DGDP + CMP URI + DCTP --> UMP + DCDP GTP + CYTD --> CMP + GDP DUTP + URI --> UMP + DUDP DUTP + CYTD --> CMP + DUDP URI + DTTP --> DTDP + UMP DCTP + CYTD --> DCDP + CMP HISxt --> HISxt_b URI + GTP --> UMP + GDP NO2xt <=> NO2xt_b O2xt <=> O2xt_b ILExt --> ILExt_b UTP + URI --> UDP + UMP GA6P --> NH3 + F6P UTP + CYTD --> UDP + CMP GLN + F6P --> GA6P + GLU CMP --> PI + CYTD GA6P <=> GA1P UMP --> URI + PI NAGA6P <=> GA6P + AC UTP + NAGA1P <=> PPI + UDPNAG DTMP --> DT + PI DCMP --> DC + PI GA1P + ACCOA --> NAGA1P + COA a_23cUMP --> a_3UMP a_23cCMP --> a_3CMP ITP + URI --> UMP + IDP ITP + CYTD --> CMP + IDP SUC --> FRU + GLC CB --> 2.0 bDGLC TRE6P --> G6P + GLC 2.0 STA --> DEXTRIN ATP + DU --> ADP + DUMP URA + PRPP <=> UMP + PPI OTHIO + NADPH --> RTHIO + NADP ATP + DCMP <=> ADP + DCDP ATP + DTDP <=> ADP + DTTP ATP + CMP <=> ADP + CDP NAD + a_2P1A --> NADH + PPN DTMP + ATP <=> DTDP + ADP NAD + a_2HBA --> OBUT + NADH OBUT + COA <=> PPACOA + FORMATE PPACOA + PI <=> COA + PROPIONYLP ATP + PROPANOATE <=> ADP + PROPIONYLP PPA + COA <=> AMP + PPACOA PI + DU --> DR1P + URA ATP + PROPANOATE <=> PPI + PPA METTHF + DUMP --> DTMP + DHF a_3HPCOA <=> PPCOA URA + R5P <=> PURI5P AKG + bALA <=> a_3OPP + GLU a_2PPG --> PI + GLYCOLATE URAxt --> URAxt_b RTHIO + CTP --> OTHIO + DCTP DUMP + ATP <=> ADP + DUDP ATP + CYTD --> ADP + CMP ATP + URI --> ADP + UMP DT + PI --> DR1P + TM ATP + DUDP <=> DUTP + ADP RTHIO + UDP --> OTHIO + DUDP RTHIO + UTP --> DUTP + OTHIO a_3HBCOA <=> R3HBCOA NADP + R3HBCOA <=> NADPH + AACCOA NAD + COA + BUTANAL --> NADH + C040COA a_3HBCOA <=> CCOA PYR + THMPP --> CO2 + a_2HETPP URI + DATP --> DADP + UMP CYTD + DATP --> DADP + CMP MMSA + NAD + COA --> NADH + CO2 + PPACOA NAD + a_3HBCOA <=> NADH + AACCOA PYR + a_2HETPP --> ACLAC + THMPP a_3HB123TC <=> PYR + SUCC a_2MCIT + COA <=> PPACOA + OA FRUxt --> FRUxt_b ACCOA + FORMATE <=> PYR + COA RTHIO + GTP --> DGTP + OTHIO NADP + MAL <=> NADPH + PYR + CO2 OA --> PYR + CO2 XMP + PPI <=> XAN + PRPP pppGpp <=> ppGpp + PI DAMP + ATP <=> ADP + DADP PPI + GMP <=> PRPP + GN ADP + ACETYLP <=> AC + ATP DOROA + UQ <=> UQH2 + OROA ATP + AC <=> AAD + PPI CAASP <=> DOROA AAD + COA <=> AMP + ACCOA ASP + CAP --> CAASP + PI AppppA --> 2.0 ADP NAD + MAL <=> NADH + PYR + CO2 ATP + OA <=> ADP + CO2 + PEP CO2 + PEP --> PI + OA ACETYLP --> AC + PI DOROA + MK <=> OROA + MKH2 ATP + FORMATE + THF --> FTHF + ADP + PI NAD + GLAL --> NADH + GLYCOLATE OROA + PRPP <=> PPI + OMP OMP --> CO2 + UMP UMP + ATP <=> UDP + ADP UDP + ATP <=> UTP + ADP GLN + ATP + UTP --> ADP + PI + GLU + CTP ATP + UTP + NH3 --> ADP + PI + CTP 2.0 ACCOA --> COA + AACCOA RTHIO + CDP --> OTHIO + DCDP GLX + ACCOA --> MAL + COA ATP + CDP <=> ADP + CTP MTG + RGT <=> LTG DT + ATP --> DTMP + ADP DHAP --> MTG + PI ATP + DCDP <=> ADP + DCTP NAD + ACAL + COA <=> NADH + ACCOA LTG --> LAC + RGT NAD + FORMATE --> NADH + CO2 ICIT --> GLX + SUCC GSNxt --> GSNxt_b ATP + SLF --> PPI + APS APS + ATP --> PAPS + ADP PAPS + RTHIO --> PAP + H2SO3 + OTHIO 3.0 NADPH + H2SO3 --> 3.0 NADP + H2S ASP <=> NH3 + FUM ACP + ACCOA --> ACACP + COA PAP --> AMP + PI 3.0 NADP + SELT --> 3.0 NADPH + SELD CO2 + ATP + ACCOA --> ADP + MALCOA + PI MALCOA + ACP --> COA + MALACP NAGLUP + NADPH --> NAGLUS + NADP + PI AG --> CO2 + PHE NAGLU + ATP --> NAGLUP + ADP GLU + ACCOA --> NAGLU + COA NAD + PRO <=> NADH + P5C NADPH + P5C <=> NADP + PRO GLUGSAL <=> P5C NADPH + GLUP --> NADP + GLUGSAL + PI ATP + GLU --> ADP + GLUP THBPT + O2 + PHE --> DHBPT + TYR a_4HPP + GLU --> TYR + AKG TRNATYR + ATP + TYR --> PPI + TRYTRNATYR + AMP DAxt --> DAxt_b NAD + a_1BOH <=> NADH + BUTANAL NAD + SUCCSA --> NADH + SUCC NADP + SUCCSA --> NADPH + SUCC GABA + AKG <=> SUCCSA + GLU a_3H3MGCOA --> AAC + ACCOA NAD + a_3B1A --> NADH + a_3BUT NAD + COA + a_3OPP --> ACCOA + NADH + CO2 UQ + NADH --> NAD + UQH2 NADH + MK --> NAD + MKH2 DCxt --> DCxt_b DMK + NADH --> NAD + DMKH2 URIxt --> URIxt_b IGP + SER --> G3P + TRP CPAD5P --> IGP + CO2 INDOLE + G3P <=> IGP INDOLE + SER --> TRP PHEN --> CO2 + PHPYR CHOR <=> PHEN NAD + PHEN --> NADH + CO2 + a_4HPP ATP + PHE + TRNAPHE --> PHETRNAPHE + PPI + AMP NPRAN --> CPAD5P CHOR + NH3 --> PYR + AN PRPP + AN --> NPRAN + PPI PPI --> 2.0 PI ADP + PI + 4.0 Hxt <=> ATP FADH2 + UQ --> UQH2 + FAD 0.5 O2 + UQH2 --> 2.0 Hxt + UQ FEROC + NO3 --> NO2 + FERIC NO2 + 3.0 NADH --> 3.0 NAD + NH3 METTHF + NADH + CO2 + NH3 --> GLY + NAD + THF CO2 --> H2CO3 BIOMASSxt --> BIOMASSxt_b 3.0 NADPH + NO2 --> NH3 + 3.0 NADP NO2 + 6.0 FEROC --> 6.0 FERIC + NH3 TRExt --> TRExt_b NADPH + DHSK --> NADP + SME DHSK <=> a_34DHB DQT --> DHSK CHOR + GLN --> PYR + GLU + AN a_3PSME --> CHOR + PI SME3P + PEP --> PI + a_3PSME ATP + SME --> SME3P + ADP SLFxt <=> SLFxt_b a_3PGxt --> a_3PGxt_b GLYCOLATExt --> GLYCOLATExt_b CTxt --> CTxt_b LYSxt --> LYSxt_b MALxt --> MALxt_b PTRCxt --> PTRCxt_b THIAMINxt <=> THIAMINxt_b C140ACP + UDPNAG --> UDPG2AA + ACP RGT --> GLU + CYSGLY UDPG2AA --> UDPG2A + AC UDPG2A + C140ACP --> UDPG23A + ACP UDPG23A --> LIPX + UMP LIPX + UDPG23A --> DISAC1P + UDP DISAC1P + ATP --> ADP + LIPIV CMPKDO + LIPIV --> KDOLIPIV + CMP KDOLIPIV + CMPKDO --> K2LIPIV + CMP K2LIPIV + C120ACP --> LK2LIPIV + ACP KDOP --> KDO + PI A5P + PEP --> PI + KDOP C140ACP + LK2LIPIV --> K2LIPA + ACP UREAxt --> UREAxt_b ATP + DGDMH7P --> DGDMH17BP + ADP DGDMH17BP --> PI + DGDMH1P KDO + CTP --> CMPKDO + PPI S7P --> DGDMH7P 1.149 UDPG + 0.142 UDPNAG + 0.387 ADPHEP + 0.09 F6P --> LPS + 0.387 ADP + 1.291 UDP + 0.09 PI DGDMH1P + ATP --> PPI + ADPDGDMHEP ADPDGDMHEP --> ADPHEP LYSxt + Hxt --> LYS LYSxt + ATP --> LYS + ADP + PI ATP + METxt --> ADP + MET + PI MET + Hxt <=> METxt ATP + LEUxt --> LEU + ADP + PI OPHSER + SCYS --> SLLCT + PI SCYS + AHSER --> SLLCT + AC Hxt + LEUxt --> LEU SHSER + SCYS --> SLLCT + SUCC LYS + Hxt <=> LYSxt SLLCT --> PYR + SHCYS + NH3 LYS + Hxt --> LYSxt NAD + ALA --> NADH + PYR + NH3 GLU + PPYR <=> a_2A3PP + AKG Hxt + ILExt --> ILE PYR + a_2AEP <=> ALA + PPAC LEU + Hxt <=> LEUxt PPAC + MCB --> a_2HPP + VB12 PHExt --> PHExt_b SMET + ATP + TRNAMET --> SMETTRNAMET + PPI + AMP SMET + ATP --> SeASMET + PPI + PI SELD + ASER --> AC + SCYS ALA <=> DALA 2.0 DALA + ATP --> PI + ALAALA + ADP DGLN --> DGLU + NH3 DGLU <=> GLU CGS --> GLC + CHD GLN --> GLU + NH3 SELNT + ATP <=> PPI + ASELNT ATP + ASELNT --> ADP + a_3PASELNT CYSGLY --> GLY + CYS a_2PGxt --> a_2PGxt_b GLN + Hxt <=> GLNxt ATP + GLNxt --> ADP + GLN + PI NADPH + A6RP5P --> NADP + A6RP5P2 Hxt + GLNxt --> GLN A6RP5P2 --> PI + A6RP Hxt + GLU <=> GLUxt RL5P --> DB4P + FORMATE ATP + GLUxt --> ADP + PI + GLU GLUxt + Hxt --> GLU CITxt --> CITxt_b DB4P + A6RP --> PI + D8RL 2.0 D8RL --> A6RP + RIBFLAV RIBFLAV + ATP --> FMN + ADP FMN --> RIBFLAV + PI ATP + FMN --> PPI + FAD NAD + E4P <=> NADH + ER4P DMB + NACN --> NAC + N15PADRDMB CYSxt + Hxt --> CYS CYSxt + ATP --> CYS + PI + ADP Hxt + DGLUxt --> DGLU DALAxt + Hxt --> DALA HISxt + Hxt --> HIS GLU + OHB <=> AKG + PHT ILE + Hxt <=> ILExt PHT --> a_4HLT + PI HIS + Hxt <=> HISxt HISxt + ATP --> ADP + PI + HIS NAD + ER4P <=> NADH + OHB PYRDX + ATP --> ADP + P5P P5P --> PYRDX + PI ATP + ILExt --> ILE + ADP + PI NAD + PHT --> NADH + a_3A2OP + CO2 a_3A2OP + DX5P --> P5P + PI LEUxt --> LEUxt_b GLUxt + Naxt --> Na + GLU ATP + PL --> PL5P + ADP PL5P --> PI + PL O2 + P5P --> PL5P + H2O2 GLYxt + Naxt --> GLY + Na GLYxt + Hxt --> GLY GLYxt + ATP --> GLY + ADP + PI GLY + Hxt <=> GLYxt ALA + Hxt <=> ALAxt ATP + ALA + UDPNAM --> UDPNAMA + ADP + PI DGLU + UDPNAMA + ATP --> ADP + UDPNAMAG + PI ALAxt + ATP --> ADP + PI + ALA SPRMDxt --> SPRMDxt_b MDAPIM + ATP + UDPNAMAG --> UDPMNLADGMD + ADP + PI ALAxt + Hxt --> ALA ATP + UDPMNLADGMD + ALAALA --> UDPMNLADGMDDADA + ADP + PI ALAxt + Naxt --> Na + ALA SLFxt + Naxt --> SLF + Na SLFxt + Hxt --> SLF ATP + SLFxt --> SLF + ADP + PI ATP + THIAMINxt --> ADP + PI + THIAMIN DALA + PPEPTIDO --> DALAxt + PEPTIDO UPPMNGNLADGNMDG5DADA --> PPEPTIDO + UDCPP GLUxt --> GLUxt_b PIxt + ATP --> 2.0 PI + ADP PIxt + 3.0 Naxt <=> PI + 3.0 Na UPPMNLADGMDDADA + UDPNAG --> UDP + UPPMNGNLADGMDDADA UDPMNLADGMDDADA + UDCP --> UPPMNLADGMDDADA + UMP 5.0 GLY + UPPMNGNLADGNMDDADA --> UPPMNGNLADGNMDG5DADA ATP + UPPMNGNLADGMDDADA + NH3 --> UPPMNGNLADGNMDDADA + ADP + PI ATP + AHM --> ADP + AHMP CYS + Hxt <=> CYSxt ATP + AHMP --> AHMPP + ADP ATP + ASPxt --> ASP + ADP + PI ACALA --> ACMUR + ALA AIR --> AHM Hxt + ASPxt --> ASP ASNxt + Hxt --> ASN ASP + Hxt <=> ASPxt UDCPP --> UDCP + PI ASN + Hxt <=> ASNxt ASNxt + ATP --> ADP + ASN + PI GLUCxt --> GLUCxt_b ARGxt + Hxt --> ARG ARGxt + ATP --> ADP + PI + ARG ARG + Hxt <=> ARGxt ORNxt --> ORNxt_b D6RP5P --> A6RP5P + NH3 GTP --> PPI + D6RP5P + FORMATE ATP + THMP <=> ADP + THMPP THMP <=> THIAMIN + PI THZP + AHMPP --> PPI + THMP CYS + OAHSER <=> AC + LLCT H2S + OAHSER --> AC + HCYS H2S + OSLHSER --> SUCC + HCYS OSLHSER --> OBUT + SUCC + NH3 RTHIO + HO3S2 + OAHSER --> OTHIO + AC + H2SO3 + HCYS BAL + FAD --> FADH2 + BETAINE ATP <=> ADP + PI + Hxt GLYCOLATExt <=> GLYCOLATE CYS + OSLHSER --> SUCC + LLCT SUCCOA + HSER <=> COA + OSLHSER NADPH + MTG --> NADP + HAC NAD + BAL --> NADH + BETAINE SLACxt + Hxt --> SLAC SUCC + MALxt <=> MAL + SUCCxt MALxt + Naxt --> Na + MAL ADNxt --> ADNxt_b MALxt + Hxt --> MAL GL3Pxt + ATP --> ADP + PI + GL3P GL3Pxt + PI <=> PIxt + GL3P SUCCxt + Naxt --> SUCC + Na SUCCxt + Hxt --> SUCC CO2xt <=> CO2 THR --> OBUT + NH3 SER + THMNP <=> GLY + MTHMNP ATP + THR + TRNATHR --> THRTRNATHR + PPI + AMP TRNASER + ATP + SER --> PPI + SERTRNASER + AMP TRNAGLY + GLY + ATP --> GLYTRNAGLY + PPI + AMP ASPSA + GLU --> a_24DAB + AKG PIxt + Hxt <=> PI NAD + DHLIPOYLPROTEIN --> LIPOYLPROTEIN + NADH GLY + LIPOYLPROTEIN --> SAP + CO2 SER <=> PYR + NH3 SER --> PYR + NH3 Na + 2.0 Hxt <=> Naxt Naxt <=> Na + Hxt 2.0 Na + 3.0 Hxt <=> 2.0 Naxt Na + 3.0 Hxt <=> Naxt NO2 --> NO2xt NH3xt <=> NH3 O2xt <=> O2 NO3xt + ATP --> ADP + PI + NO3 ASPxt --> ASPxt_b CYSxt --> CYSxt_b SUCCxt --> SUCCxt_b SAP + THF --> DHLIPOYLPROTEIN + METTHF + NH3 MELIxt --> MELIxt_b GLY + ACCOA <=> a_2A3OB + COA NAD + THR --> a_2A3OB + NADH THR <=> GLY + ACAL ATHR <=> GLY + ACAL a_3PSER --> SER + PI THF + SER <=> GLY + METTHF GLU + PHP --> AKG + a_3PSER NAD + a_3PG --> NADH + PHP PHSER --> PI + THR ATP + a_2PGxt --> ADP + a_2PG + PI PEP + TRExt --> PYR + TRE6P SUCxt + PEP --> PYR + SUC6P PEP + NAGAxt --> NAGA6P + PYR MNTxt + PEP --> PYR + MNT1P MELIxt + Naxt --> Na + MELI MELIxt + Hxt --> MELI MLTxt + ATP --> ADP + PI + MLT Hxt + GLUCxt --> GLUC GLCxt + PEP --> G6P + PYR NADPH + BASP --> NADP + ASPSA + PI ASPSA + NADH <=> NAD + HSER NADPH + ASPSA <=> NADP + HSER ATP + HSER --> PHSER + ADP PYR + GLU <=> AKG + ALA ASP --> CO2 + bALA CNS --> HIS + bALA ASP + ATP --> ADP + BASP ASN --> ASP + NH3 GLN + ATP + ASP --> ASN + PPI + AMP + GLU SUCC + FUMxt <=> SUCCxt + FUM Naxt + FUMxt --> Na + FUM ICITxt + Naxt --> Na + ICIT CITxt + Naxt --> Na + CIT CITxt <=> CIT Hxt + FUMxt --> FUM FORMATE --> FORMATExt a_3PGxt + ATP --> ADP + PI + a_3PG AKGxt + Hxt --> AKG AC <=> ACxt + Hxt NAD + 2.0 RGT <=> NADH + OGT ATP + GLY + GCYS --> RGT + ADP + PI GLN + ATP + TRNAGLN --> GTRNA + PPI + AMP GLU + TRNAGLU + ATP --> GLUTRNAGLU + PPI + AMP ATP + ALA + TRNAALA <=> PPI + AMP + ALATRNA 8.0 NADPH + ACACP + 4.0 MALACP --> 8.0 NADP + 4.0 ACP + C100ACP + 4.0 CO2 TRNAASP + ASP + ATP --> ASPTRNAASP + PPI + AMP 6.0 NADPH + PPAACP + 3.0 MALACP --> 6.0 NADP + 3.0 CO2 + 3.0 ACP + C090ACP GLU + OA <=> ASP + AKG ACP + PPACOA --> COA + PPAACP NADP + 2.0 RGT <=> NADPH + OGT ASN + ATP + TRNAASN --> PPI + AMP + ASNTRNAASN 10.0 NADPH + PPAACP + 5.0 MALACP --> 10.0 NADP + 5.0 ACP + C130ACP + 5.0 CO2 12.0 NADPH + ACACP + 6.0 MALACP --> 12.0 NADP + 6.0 ACP + 6.0 CO2 + C140ACP 8.0 NADPH + PPAACP + 4.0 MALACP --> 8.0 NADP + 4.0 CO2 + 4.0 ACP + C110ACP 10.0 NADPH + ACACP + 5.0 MALACP --> 10.0 NADP + 5.0 ACP + C120ACP + 5.0 CO2 14.0 NADPH + ACACP + 7.0 MALACP --> 14.0 NADP + 7.0 ACP + C160ACP + 7.0 CO2 ATP + GLU + CYS --> ADP + PI + GCYS 12.0 NADPH + PPAACP + 6.0 MALACP --> 12.0 NADP + 6.0 ACP + C150ACP + 6.0 CO2 11.0 NADPH + PPAACP + 6.0 MALACP --> C151ACP + 6.0 ACP + 11.0 NADP + 6.0 CO2 CYSTEATE --> CO2 + TR a_3SLALA --> CO2 + HTR O2 + AKG + TR --> CO2 + SUCC + H2SO3 + AAA NAGLUS + GLU --> NAORN + AKG ORN + CAP <=> CITR + PI NAORN --> AC + ORN ARGSUCC <=> ARG + FUM ASP + CITR + ATP <=> PPI + ARGSUCC + AMP SPRM + a_5MTA --> SPRMD + SAMA NAD + bAPA --> NADH + bALA SAM + a_2P14NQ --> SAH + PQ 0.673 LEU + 40.0 ATP + 0.438 ASP + 0.115 TYR + 1.521 ALA + 0.479 ILE + 0.438 ASN + 0.196 HIS + 0.5 THR + 0.373 LYS + 0.384 ARG + 0.392 PRO + 0.283 PHE + 0.712 VAL + 0.407 SER + 1.002 GLY + 0.645 GLN + 0.126 MET + 0.108 CYS + 0.645 GLU + 0.109 TRP --> 40.0 PI + 40.0 ADP + PROTEIN 0.756 DGTP + 4.4 ATP + 0.863 DTTP + 0.756 DCTP + 0.863 DATP --> 3.237 PPI + DNA + 4.4 PI + 4.4 ADP GLxt --> GLxt_b 0.675 UTP + 0.946 GTP + 2.023 ATP + 0.696 CTP --> 3.09 PPI + RNA + 1.25 ADP + 1.25 PI 0.155 a_2AG3PE + 0.268 PG + 0.908 PE --> PHOSPHOLIPID 0.168 NADP + 0.159 FAD + 0.188 NAD + 0.281 THF + 0.274 FMN + 0.739 PYRDX + 0.163 COA + 0.405 MK --> CAV MNTxt --> MNTxt_b 46.0 ATP + 0.034 LPS + 0.205 RNA + 0.091 PHOSPHOLIPID + 0.031 DNA + 0.03 CAV + 0.55 PROTEIN + 0.025 PEPTIDO + 0.025 GLYCOGEN --> BIOMASSxt + 46.0 ADP + 46.0 PI ATP --> ADP + PI IMALxt + ATP <=> IMAL + ADP + PI FRUxt + PEP --> F1P + PYR GL3Pxt --> GL3Pxt_b GLYxt --> GLYxt_b NH3xt <=> NH3xt_b FORMATExt --> FORMATExt_b GLU + a_3MOP <=> ILE + AKG DHMP --> a_3MOP 18.0 NADPH + ACACP + 9.0 MALACP --> C200ACP + 9.0 ACP + 18.0 NADP + 9.0 CO2 OICAP --> a_4MOP + CO2 15.0 NADPH + PPAACP + 8.0 MALACP --> 15.0 NADP + 8.0 ACP + C191ACP + 8.0 CO2 NAD + CBHCAP --> NADH + OICAP 16.0 NADPH + PPAACP + 8.0 MALACP --> 16.0 NADP + 8.0 ACP + 8.0 CO2 + C190ACP Naxt <=> Naxt_b IPPMAL <=> CBHCAP 15.0 NADPH + ACACP + 8.0 MALACP --> 15.0 NADP + C181ACP + 8.0 ACP + 8.0 CO2 OIVAL + ACCOA --> IPPMAL + COA ILE + ATP + TRNAILE --> ILETRNAILE + PPI + AMP TRNAVAL + VAL + ATP --> VALTRNAVAL + PPI + AMP C140 + 6.0 FAD + 6.0 NAD + 7.0 COA + ATP --> PPI + 6.0 FADH2 + 7.0 ACCOA + 6.0 NADH + AMP LEU + TRNALEU + ATP --> LEUTRNA + PPI + AMP C120 + 5.0 FAD + 5.0 NAD + 6.0 COA + ATP --> PPI + 5.0 FADH2 + 6.0 ACCOA + 5.0 NADH + AMP a_4MOP + GLU <=> LEU + AKG 13.0 NADPH + PPAACP + 7.0 MALACP --> 13.0 NADP + 7.0 ACP + C171ACP + 7.0 CO2 16.0 NADPH + ACACP + 8.0 MALACP --> 16.0 NADP + C180ACP + 8.0 ACP + 8.0 CO2 13.0 NADPH + ACACP + 7.0 MALACP --> C161ACP + 7.0 ACP + 13.0 NADP + 7.0 CO2 14.0 NADPH + PPAACP + 7.0 MALACP --> 14.0 NADP + 7.0 ACP + C170ACP + 7.0 CO2 CO2xt <=> CO2xt_b NADPH + DX5P --> NADP + MDE4P PYR + G3P --> CO2 + DX5P CDPMDE + ATP --> a_2PCDPMDE + ADP MDE4P + CTP --> PPI + CDPMDE a_2PCDPMDE --> MDECPP + CMP C150 + 6.0 FAD + 6.0 NAD + 7.0 COA + ATP --> PPI + 6.0 FADH2 + 6.0 ACCOA + 6.0 NADH + AMP + PPACOA C160 + 7.0 FAD + 7.0 NAD + 8.0 COA + ATP --> PPI + 7.0 FADH2 + 8.0 ACCOA + 7.0 NADH + AMP VALxt --> VALxt_b 7.0 FAD + 7.0 NAD + 8.0 COA + ATP + C161 --> PPI + 7.0 FADH2 + 8.0 ACCOA + 7.0 NADH + AMP 8.0 FAD + 8.0 NAD + 9.0 COA + ATP + C180 --> PPI + 8.0 FADH2 + 9.0 ACCOA + 8.0 NADH + AMP 8.0 FAD + 8.0 NAD + C181 + 9.0 COA + ATP --> PPI + 8.0 FADH2 + 9.0 ACCOA + 8.0 NADH + AMP HPPP + IPP --> HEPPP + PPI PPPP + IPP --> HPPP + PPI IPP + GGPP --> PPI + PPPP FPP + IPP --> PPI + GGPP GPP + IPP --> FPP + PPI 2.0 NADPH + a_3H3MGCOA --> 2.0 NADP + COA + MVLN IPP <=> DMPP DMPP + IPP --> GPP + PPI MDECPP + NADH --> HMB4PP + NAD HMB4PP + NADH --> NAD + IPP NADH + DHAP --> NAD + GL3P TGL --> 0.39 C160 + 0.182 C140 + DGR + 0.052 C120 + 0.076 C181 + 0.01 C180 + 0.05 C150 + 0.24 C161 NADPH + DHAP --> NADP + GL3P NADH + T3 <=> NAD + GL NADPH + T3 <=> NADP + GL ATP + GL --> ADP + GL3P DGR --> 0.39 C160 + 0.182 C140 + 0.052 C120 + AGL + 0.076 C181 + 0.01 C180 + 0.05 C150 + 0.24 C161 HEPPP + IPP --> OPP + PPI ADP + a_3PG <=> DGLYCERATE + ATP NADH + DGLYCERATE <=> NAD + T3 LLCT --> PYR + NH3 + HCYS MTHF + HCYS <=> THF + MET G3PC --> CHOLINE + GL3P PA + CTP <=> CDPDG + PPI ATP + MET + TRNAMET --> PPI + METTRNA + AMP METTRNA + FTHF --> FMETTRNA + THF a_5MTGLU + HCYS --> TGLU + MET SRLH <=> HCYS + RIB ACOA + GL3P --> a_2AGL3P + COA CYST --> TCYS + PYR + NH3 DMKH2 + DHAP <=> DMK + GL3P H2S + PYR + NH3 --> CYS DHAP + MKH2 <=> GL3P + MK SAH <=> AD + SRLH UQH2 + DHAP <=> GL3P + UQ MET + ATP --> PPI + PI + SAM PC --> 0.39 C160 + 0.182 C140 + a_2AG3PC + 0.052 C120 + 0.076 C181 + 0.01 C180 + 0.05 C150 + 0.24 C161 ATP + DGR --> ADP + PA 0.24 C161ACP + 0.076 C181ACP + 0.05 C150ACP + 0.39 C160ACP + 0.052 C120ACP + 0.182 C140ACP + 0.01 C180ACP + AGL3P --> PA + ACP 0.24 C161ACP + 0.076 C181ACP + 0.05 C150ACP + 0.39 C160ACP + 0.052 C120ACP + 0.01 C180ACP + 0.182 C140ACP + GL3P --> AGL3P + ACP GLN + PRPP --> PRAM + PPI + GLU SER + ACCOA <=> COA + ASER H2S + ASER --> CYS + AC NADH + MPYR --> NAD + a_3MLAC RTHIO + HO3S2 + ASER --> OTHIO + CYS + AC + H2SO3 HO3S2 + ASER --> AC + SSLCYS AKG + CYSTEATE <=> a_3SPYR + GLU AKG + a_3SLALA --> a_3SFPYR + GLU DGLUxt --> DGLUxt_b CDPDG + SER <=> PS + CMP PS --> CO2 + PE SER --> a_2AA PS --> 0.39 C160 + 0.182 C140 + a_2AG3PS + 0.052 C120 + 0.076 C181 + 0.01 C180 + 0.05 C150 + 0.24 C161 GLU + MPYR --> AKG + CYS G3PE --> GL3P + ETHA PE --> 0.39 C160 + 0.182 C140 + 0.052 C120 + 0.076 C181 + 0.24 C161 + 0.01 C180 + 0.05 C150 + a_2AG3PE TRNACYS + ATP + CYS --> PPI + CYSTRNACYS + AMP PGP --> PG + PI CDPDG + GL3P <=> PGP + CMP ATP + R5P <=> PRPP + AMP CDPDG + PG --> CMP + CL a_3HIVCOA <=> a_3MCCOA a_2MP2ECOA --> a_3HIBCOA COA + S2MBDHL --> a_2MBCOA + DLIPO a_3MBCOA + FAD --> a_3MCCOA + FADH2 OIVAL + LIPO --> S2MPDHL + CO2 S2MPDHL + COA --> a_2MPPACOA + DLIPO NAD + HIBUT --> NADH + a_3OPP S3MBDHL + COA --> a_3MBCOA + DLIPO FTHF + GAR --> THF + FGAR PRAM + ATP + GLY <=> ADP + PI + GAR IMP + ASP + GTP --> ASUC + GDP + PI PRFICA <=> IMP AICAR + FTHF <=> THF + PRFICA SAICAR <=> AICAR + FUM CAIR + ATP + ASP <=> ADP + SAICAR + PI AIR + ATP + CO2 --> CAIR + ADP + PI FGAM + ATP --> AIR + ADP + PI a_3MCCOA + ATP + HCO3 --> ADP + PI + a_3MGCOA GLN + ATP + FGAR --> FGAM + ADP + PI + GLU a_3H2MBCOA --> a_2MB2ECOA DHMVA --> OIVAL OIVAL + GLU <=> VAL + AKG OIVAL + ALA --> VAL + PYR OBUT + a_2HETPP --> ABUT + THMPP NAD + a_3H2MBCOA <=> NADH + a_2MAACCOA NAD + MMSA --> MM + NADH a_2MAACCOA + COA --> PPACOA + ACCOA NADPH + ACLAC --> NADP + DHMVA NAD + HIBUT <=> NADH + MMSA NAGAxt --> NAGAxt_b ASUC <=> AMP + FUM XMP + GLN + ATP --> PPI + GMP + GLU + AMP NAD + IMP --> XMP + NADH ADN --> INS + NH3 ATP + GSN <=> ADP + GMP DA <=> DIN + NH3 a_23cAMP --> a_3AMP ABUT + NADPH --> DHMP + NADP NADPH + GMP --> IMP + NH3 + NADP INS + ATP <=> IMP + ADP a_23cGMP --> a_3GMP DAMP <=> DA + PI DGMP <=> PI + DG DIN + PI --> DR1P + HYXN PYR + DATP <=> DADP + PEP PYR + GTP <=> GDP + PEP DGDP + PEP --> DGTP + PYR DTxt --> DTxt_b IMP --> INS + PI AMP --> ADN + PI XMP --> XTSINE + PI GMP --> PI + GSN ARGxt --> ARGxt_b PRPP + QA --> CO2 + PPI + NACN NACN --> NACD + PI VB12xt <=> VB12xt_b O2 + PYRDX <=> H2O2 + PL PDLA5P --> PDLA + PI PDLA + ATP --> ADP + PDLA5P O2 + PDLA5P --> PL5P + H2O2 + NH3 IASP + DHAP --> PI + QA ASP + O2 --> H2O2 + IASP ACxt --> ACxt_b ASP + FUM --> SUCC + IASP O2 + NH3 + PL <=> H2O2 + PDLA GLNxt --> GLNxt_b MLTxt --> MLTxt_b FUMxt --> FUMxt_b AKGxt --> AKGxt_b Hxt <=> Hxt_b ALAxt --> ALAxt_b THRxt --> THRxt_b METxt --> METxt_b DALAxt --> DALAxt_b PROxt --> PROxt_b TYRxt --> TYRxt_b NO3xt <=> NO3xt_b IMALxt --> IMALxt_b BT + ATP --> PPI + B5AMP AHHMP + PABA --> DHPT AHHMP + ATP --> AHHMD + AMP CHOR + GLN --> ADCHOR + GLU ADCHOR --> PYR + PABA AHHMD + PABA --> DHPT + PPI A_C_ + B5AMP --> H_C_ + AMP GTP --> AHTD + FORMATE AHTD --> PPI + PI + DHP DHP --> AHHMP + GLAL NADPH + DHF --> THF + NADP DHPT + ATP + GLU --> ADP + PI + DHF XANxt --> XANxt_b AHTD --> H5P3O10 + PYTHP DHBPT + NADH <=> THBPT + NAD NADPH + FL --> THF + NADP ATP + THF + GLU <=> THFG + ADP + PI NADP + DHF <=> NADPH + FL NADH + FL --> NAD + THF NADH + DHF --> NAD + THF NAD + DHF <=> NADH + FL DHBPT + NADPH <=> THBPT + NADP METHF --> FTHF GAR + METHF --> THF + FGAR DUxt --> DUxt_b METHF --> a_5FTHF NADP + METTHF <=> NADPH + METHF METHF <=> FTHF NADPH + METTHF --> NADP + MTHF METTHF + FADH2 <=> MTHF + FAD METTHF + DUMP <=> DTMP + DHF FTHF <=> THF + FORMATE 4.0 PBG --> HMB + 4.0 NH3 2.0 ALAV --> PBG GSA --> ALAV NADPH + GTRNA --> NADP + GSA DGxt --> DGxt_b ADPG --> ADP + GLYCOGEN PI + GLYCOGEN --> G1P PI + MLTHPT <=> G1P + MLTHX MLT + MLTTR --> MLTTTR + GLC SUCxt --> SUCxt_b MLTPT + PI <=> MLTTTR + G1P PI + MLTHX <=> MLTPT + G1P NAD + PC2 --> NADH + SHCL MLT + MLTHX --> GLC + MLTHPT SHCL --> SHEME IMAL --> 2.0 GLC HMB --> UPRG MLTTTR + MLT --> MLTPT + GLC UPRG + 2.0 SAM --> 2.0 SAH + PC2 MLTPT + MLT --> GLC + MLTHX UPRG --> CPP + 4.0 CO2 CPP + 2.0 SAM --> 2.0 CO2 + 2.0 MET + 2.0 DA + PPHG 1.5 O2 + PPHG --> PPIX PPIX --> PTH ATP + CIDA --> ACDA + PPI + PI 4.0 GLN + 4.0 ATP + ACDA --> ACHA + 4.0 ADP + 4.0 PI + 4.0 GLU O2 + CPP --> 2.0 CO2 + PPHG ADCBAP + GTP --> PPI + AGDPCBA ATP + G1P --> PPI + ADPG D1AP2OOP + ATP + ACHA --> ADCBAP + ADP + PI LXYLULOSE5P --> LRIBULOSE5P ACHA + a_1AP2O --> ADCBA NAD + DGLUCL <=> DGLUCA + NADH ADCBA + GTP --> GDP + ADCBAP NAD + a_2D3DDX <=> NADH + a_5H24DP ADCBA + ATP --> ADCBAP + ADP a_3DG6P --> LXYLULOSE5P + CO2 a_3KL <=> bDGLC + a_3KBDG PI + LACTOSE --> L6P NADP + a_3KBDG <=> NADPH + bGLAC ATP + T6P <=> T16B + ADP LACTOSE --> GLAC + GLC CHOR <=> a_4HB + PYR a_4HB + OPP --> PPI + a_3OP4HB NADH + 2.0 ACIIIA --> 2.0 CIIA + NAD CHOR <=> ICHOR N15PADRDMB --> ARBZ + PI AGDPCBA + ARBZ --> CBCO + GMP G6GG --> GLAC + MELI GALACTINOL --> MI + GLAC NADPH + O2 + a_2OP6MP --> a_2OP6M14BQ + NADP MELT <=> GLAC + SOT a_2OP6HP + SAM --> SAH + a_2OP6MP GGL <=> GLAC + GL NADPH + O2 + a_2OPP --> a_2OP6HP + NADP EPM <=> GLAC + MAN a_3OP4HB --> a_2OPP + CO2 MELI --> GLAC + GLC STACHYOSE --> GLAC + RAF RAF --> GLAC + SUC UTP + G1P <=> UDPG + PPI GAL1P + UTP <=> UDPGAL + PPI a_2OP6M14BQ + SAM --> SAH + a_2OP3M6M14BQ NADPH + O2 + a_2OP3M6M14BQ --> a_2OP3M5H6M14BQ + NADP a_2OP3M5H6M14BQ + SAM --> SAH + UQ ICHOR + AKG --> CO2 + PYR + SHCHC SHCHC --> OSB OSB + ATP + COA --> PPI + OSBCOA + AMP OSBCOA --> DHN + COA DMK + SAM --> MKH2 + SAH NAD + MNT1P --> NADH + F6P DHN + OPP --> DMK + CO2 + PPI MAN1P + GTP <=> GDPMAN + PPI S6P + NADP <=> SB1P + NADPH DHN + PPP --> CO2 + PPI + a_2P14NQ F2P <=> FRU + PI GAL1P + UDPG <=> UDPGAL + G1P CHOLINExt --> CHOLINExt_b GLAC + ATP --> GAL1P + ADP UDPG <=> UDPGAL F1P --> DHAP + T3 MAN6P <=> MAN1P MAN6P <=> F6P KDG <=> DMAN NAD + KDG <=> DDOH + NADH DGALAC --> DTAGA D6PGC --> KDPG F1P + ATP --> ADP + FDP 2.0 NAD + UDPG <=> 2.0 NADH + UDPGLUC DGLUC <=> DFRUC ASNxt --> ASNxt_b DMAN + NAD <=> NADH + DFRUC GLUC + ATP --> ADP + D6PGC ATP + KDG --> ADP + KDPG GLCxt <=> GLCxt_b RL5P <=> R5P TRNAHIS + ATP + HIS --> HISTRNAHIS + PPI + AMP HIS --> UC + NH3 2.0 NAD + HISOL --> HIS + 2.0 NADH HIS + SAM --> NMHIS + SAH IMACP + GLU --> HISOLP + AKG HISOLP --> HISOL + PI DRIB + ATP --> ADP + DR5P DR1P <=> DR5P G3P + S7P <=> E4P + F6P DR5P --> ACAL + G3P R5P + X5P <=> G3P + S7P E4P + X5P <=> F6P + G3P ATP + RIB --> ADP + R5P SERxt --> SERxt_b R1P <=> R5P DTxt + Hxt --> DT DGxt + Hxt --> DG DCxt + Hxt --> DC Hxt + DAxt --> DA CYTDxt + Hxt --> CYTD ADNxt + Hxt --> ADN GLxt <=> GL KDPG --> PYR + G3P DIMGP --> IMACP GLN + PRLP --> AICAR + DIMGP + GLU PRFP --> PRLP PRBAMP --> PRFP URIxt + Hxt --> URI GSNxt + Hxt --> GSN DUxt + Hxt --> DU HYDROXYAKG --> GLX + PYR ATP + PRPP --> PPI + PRBATP PRBATP --> PRBAMP + PPI a_4AB + NADP --> NADPH + GABA SAMA + PTRC --> SPRMD + a_5MTA HCNS --> GABA + HIS a_5MTA --> a_5MDR + AD NAD + MAL <=> NADH + OA PIxt <=> PIxt_b G6P + NADP --> NADPH + D6PGL NAD + G6P --> NADH + D6PGL D6PGL --> D6PGC SUCC + FAD --> FADH2 + FUM FUM + MKH2 --> SUCC + MK DMKH2 + FUM --> DMK + SUCC FUM <=> MAL XANxt + Hxt --> XAN RL5P <=> X5P CTxt + Hxt --> CT NADP + D6PGC --> NADPH + RL5P + CO2 ATP + VB12xt --> ADP + PI + VB12 URAxt + Hxt --> URA E4HGLU + AKG --> HYDROXYAKG + GLU NAD + N4AAB --> NADH + a_4AABUT HYDROXYAKG <=> GLX + PYR PEP + E4P --> PI + a_3DDAH7P a_3DDAH7P --> DQT + PI 2.0 O2 + 2.0 a_3HAN --> CVN + 2.0 H2O2 a_2OAD + NAD + COA --> NADH + CO2 + GLUTCOA ATP + AC + COA <=> PPI + ACCOA + AMP NAD + ACAL --> NADH + AC NAD + DLIPO --> NADH + LIPO ICITxt --> ICITxt_b CIT <=> ICIT NADP + ICIT --> NADPH + AKG + CO2 ACAL + NADH <=> NAD + ETH OA + ACCOA --> COA + CIT ADP + PI + SUCCOA <=> SUCC + ATP + COA SDLIPO + COA --> SUCCOA + DLIPO AKG + LIPO --> SDLIPO + CO2 DPHE --> PHPYR + NH3 O2 + PHPYR --> a_2HPA + CO2 I3AA + NAD --> I3AC + NADH NAD + a_5HIAA --> NADH + a_5HIAC TRP + ATP + TRNATRP --> PPI + AMP + TRPTRNATRP TRP --> INDOLE + PYR + NH3 AKG + TYR <=> a_4HPP + GLU O2 + a_4HPP --> HOMOGEN + CO2 a_4MAAC --> a_4FAAC NAD + a_34DHPEG <=> NADH + a_34DHMA AKG + PHE <=> PHPYR + GLU DHAP <=> G3P NAD + G3P + PI <=> a_13PDG + NADH a_13PDG + ADP <=> ATP + a_3PG a_13PDG + ADP --> ATP + a_3PG a_3PG <=> a_2PG a_2PG <=> PEP NAD + SLAC <=> NADH + PYR PEP + ADP --> PYR + ATP ADLIPO + COA --> ACCOA + DLIPO PYR + LIPO --> ADLIPO + CO2 UC --> a_4I5P NFGLU --> FA + GLU a_4I5P --> NFGLU a_5CM2HM --> a_5C2O3E NAD + I4AA --> NADH + I4AC G6P <=> F6P A6P --> bDG6P + HQ G6P <=> bDG6P GLC <=> bDGLC a_2OAD + LIPO --> CO2 + SGDHL LYS + ATP + TRNALYS --> PPI + LYSTRNA + AMP GTP --> cGMP + PPI MDAPIM --> LYS + CO2 ATP --> PPI + cAMP DAPIM <=> MDAPIM SDAPIM --> DAPIM + SUCC SAOPIM + GLU --> SDAPIM + AKG SUCCOA + TDHDP --> COA + SAOPIM DHDP + NADH --> NAD + TDHDP DHDP + NADPH --> NADP + TDHDP PYR + ASPSA --> DHDP PRPP + HYXN --> IMP + PPI XAN + PRPP --> XMP + PPI AD + PRPP --> PPI + AMP PRPP + GN --> PPI + GMP ATP + DIDP <=> DITP + ADP AICAR + PPI <=> a_5A4IC + PRPP ATP + DGMP <=> DGDP + ADP ATP + IDP <=> ITP + ADP FDP <=> DHAP + G3P ATP + F6P --> ADP + FDP FDP --> F6P + PI bDG6P <=> F6P G6P <=> G1P ATP + NACN --> PPI + NAAD NAC + PRPP --> PPI + NACN NAC + R1P --> NACD + PI GLN + NAAD + ATP --> GLU + NAD + PPI + AMP NACD + ATP --> ADP + NACN NAMN --> NAMD + PI NAM --> NAC + NH3 NAM + R1P --> PI + NAMD NAD + ATP --> NADP + ADP NADP + NADH --> NADPH + NAD Hxt + SER <=> SERxt SERxt + ATP --> ADP + PI + SER PRO + Hxt <=> PROxt PROxt + ATP --> PRO + ADP + PI PROxt + Hxt --> PRO PROxt + Naxt --> PRO + Na METxt + Hxt --> MET PHE + Hxt <=> PHExt ATP + PHExt --> ADP + PI + PHE Hxt + PHExt --> PHE CYTDxt --> CYTDxt_b 2.0 PYR --> CO2 + ACLAC NADPH + NAD <=> NADP + NADH NADP --> NAD + PI ATP + PNTO --> a_4PPNTO + ADP PANT + ATP + bALA --> PPI + PNTO + AMP NADPH + DHPANT --> NADP + PANT METTHF + OIVAL --> THF + DHPANT NADH + L1P3H5C --> NAD + a_4HPRO a_4HPRO + FAD --> L1P3H5C + FADH2 CYS + CTP + a_4PPNTO --> PPI + a_4PPNCYS + CMP PRO + TRNAPRO + ATP --> PROTRNAPRO + PPI + AMP PTT + ATP --> ADP + a_4PPNTE PRO + FAD --> FADH2 + P5C ATP + NPCYS --> a_4PPNCYS + ADP NAD + E4HGLU <=> NADH + a_4HGLUSA ATP + DADP <=> ADP + DATP L1P3H5C + NADP --> NADPH + E4HGLU RTHIO + ADP --> OTHIO + DADP NAD + L1P3H5C --> E4HGLU + NADH ATP + AMP <=> 2.0 ADP NADPH + L1P3H5C --> a_4HPRO + NADP ppGpp <=> PPI + GDP TYR + Hxt <=> TYRxt RTHIO + GDP --> DGDP + OTHIO ATP + TYRxt --> TYR + PI + ADP DGDP + ATP <=> DGTP + ADP TRPxt + ATP --> ADP + PI + TRP ATP + GMP <=> ADP + GDP TRPxt + Hxt --> TRP ATP + GDP <=> ADP + GTP NADP + P5C --> NADPH + GLU NAD + GLUGSAL --> NADH + GLU Hxt + TYRxt --> TYR ARIB --> AMP + R5P RTHIO + ATP --> OTHIO + DATP SERxt + Hxt --> SER THRxt + Hxt --> THR TRP + Hxt <=> TRPxt Hxt + THR <=> THRxt THRxt + ATP --> ADP + PI + THR ATP + a_4PPNTE --> PPI + DPCOA a_4PPNCYS --> CO2 + a_4PPNTE NAD + P5C --> NADH + GLU AACP + COA --> PAP + ACP ATP + DPCOA --> COA + ADP TRPxt --> TRPxt_b PTT --> PNTO + CA ACP --> AACP + a_4PPNTE SAM + AONA <=> SAMOB + DANNA CHCOA + ALA <=> CO2 + COA + AONA S + DTB --> BT SUCCOA + ARG <=> N2SUCCARG + COA ATP + CO2 + DANNA <=> DTB + ADP + PI ARG --> CITR + NH3 ORN --> CO2 + PTRC TRNAARG + ATP + ARG <=> ARGTRNAARG + PPI + AMP ARG --> CO2 + AGMATINE PPI + AMP <=> AD + PRPP AGMATINE --> UREA + PTRC N2SUCCGLU --> SUCC + GLU DA + PI <=> DR1P + AD NAD + N2SUCCGLU5SA <=> NADH + N2SUCCGLU DIN + PI <=> DR1P + HYXN PTRCxt + ATP --> PTRC + PI + ADP DG + PI <=> DR1P + GN ATP + SPRMDxt --> ADP + SPRMD + PI R1P + HYXN <=> INS + PI ATP + UREAxt --> ADP + PI + UREA R1P + AD <=> ADN + PI Hxt + CHOLINExt --> CHOLINE R1P + GN <=> PI + GSN R1P + XAN <=> XTSINE + PI DGTP --> H5P3O10 + DG ATP + GTP --> pppGpp + AMP GLUTCOA + DLIPO <=> SGDHL + COA VAL + Hxt <=> VALxt ATP + VALxt --> VAL + ADP + PI Hxt + VALxt --> VAL HSER + Hxt <=> HSERxt ORNxt + ATP --> ORN + ADP + PI PTRCxt + ORN <=> ORNxt + PTRC