Warp is a web framework based on Twisted Web, using the Storm ORM, Mako templating, and jQuery.
It’s designed to be batteries-included (auth, sessions, URL routing, CRUD, access control, etc), easy to get started with, and capable of leveraging all the power of Twisted.
Warp is currently being developed by Brendon Hogger for Cogini, but it’s open source and help is more than welcome.
Warp has an IRC channel, #warp, on Freenode.