psphere provides native Python bindings for the vSphere Web Services SDK (formerly known as VMware Infrastructure SDK). The project is in its early phases but can already perform most query operations and virtual machine creation.
psphere is in no way affiliated with VMware Inc.
The code can be found in a Mercurial repository, at my bitbucket page.
Get in touch via bitbucket if you think that you can contribute to psphere. This is my first Python and open-source project so I would appreciate any feedback or advice!